Projects / Programmes source: ARRS

Antitromboticne lastnosti petidomemetikov (Slovene)

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
P320  Natural sciences and mathematics  Nucleic acids, protein synthesis 
thrombosis, thrombin, coagulation factor, proteinase inhibitor, antagonist, peptidomimetic, platelet, platelet aggregation, glycoproteine receptor, antithrombotic drug
Evaluation (rules)
source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15637  PhD Mojca Božič Mijovski  Medical sciences  Researcher  2000 - 2002  199 
2.  05965  PhD Matija Kozak  Medical sciences  Researcher  2000 - 2002  319 
3.  05034  PhD Mojca Stegnar  Medical sciences  Principal Researcher  2000 - 2002  343 
4.  17725  Marinka Tehovnik    Researcher  2000 - 2002 
5.  20128  PhD Alenka Trampuš Bakija  Medical sciences  Researcher  2000 - 2002  120 
6.  03392  MSc Viktor Videčnik  Medical sciences  Researcher  2000 - 2002  103 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  73,829 
Anticoagulants which are used for treatment of thrombosis have limitations due to side effects and complicated laboratory monitoring. Use of antiplatelet drugs is limited since they inhibit only certain activation processes. The aim of the project is to test antithrombotic properties of peptidomimetics (potential selective and reversible inhibitors of thrombin and platelet membrane glycoprotein receptor GP IIa/IIIb antagonists) in vitro in pure enzyme/inhibitor/substrate systems, in biological systems with clotting and platelet aggregation assays, in vivo in animals and in animal models of thrombosis. It is expected that substances which inhibit thrombin and platelet aggregation in nM concentrations will be found. These inhibitors would be basic substances for the development of antithrombotic dugs.
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