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Projects / Programmes source: ARIS

Struktura in funkcija skeletne mišice (Slovene)

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Periods
January 1, 1999 - December 31, 2003
Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
b210  Biomedical sciences  Histology, cytochemistry, histochemistry, tissue culture 
b440  Biomedical sciences  Human anatomy and morphology 
B350  Biomedical sciences  Development biology, growth (animal), ontogeny, embryology 
B580  Biomedical sciences  Skeleton, muscle system, rheumatology locomotion 
B725  Biomedical sciences  Diagnostics 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (17)
no. Code Name and surname Research area Role Period No. of publications
1.  17930  Ivan Blažinovič    Researcher  2001 - 2003  2 
2.  10644  PhD Erika Cvetko  Neurobiology  Researcher  2001 - 2003  281 
3.  11785  PhD Vita Čebašek  Neurobiology  Researcher  2001 - 2003  66 
4.  21610  Majda Črnak-Maasarani    Researcher  2001 - 2003  0 
5.  05329  PhD Ida Eržen  Neurobiology  Head  2001 - 2003  212 
6.  10642  PhD Marija Hribernik  Neurobiology  Researcher  2001 - 2003  137 
7.  17957  Brane Matičič    Researcher  2001 - 2003  0 
8.  04905  PhD Marija Meznarič  Neurobiology  Researcher  2001 - 2003  152 
9.  19217  MSc Boštjan Mlakar  Cardiovascular system  Researcher  2001 - 2003  155 
10.  03448  PhD Dean Ravnik  Cardiovascular system  Researcher  2001 - 2003  179 
11.  17961  Marko Slak    Researcher  2001 - 2003  8 
12.  10641  PhD Viktorija Smerdu  Neurobiology  Researcher  2001 - 2003  91 
13.  09156  PhD Branka Stirn Kranjc  Neurobiology  Researcher  2001 - 2003  386 
14.  19216  PhD Larisa Stojanovič  Cardiovascular system  Researcher  2001 - 2003  35 
15.  17962  Milan Števanec    Researcher  2001 - 2003  21 
16.  17963  Anica Tomažinčič    Researcher  2001 - 2003  0 
17.  20819  Andreja Vidmar    Researcher  2001 - 2003  1 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,203 
Abstract
Plasticity of skeletal and extraocular rat muscles has been studied by myosin heavy chain expression in different experimental conditions, e.g. (i) continuous low frequency electrical stimulation of Marcaine injected rat fast extensor digitorum longus muscle (EDL), (ii) transposition of the nerve, innervating EDL muscle, to the slow soleus muscle, Marcaine injected and non-injected, (iii) transplantation of soleus or EDL muscle from young rats into adult EDL muscle in euthyroid, hyperthyroid and hypothyroid conditions, (iv) one to two years after Marcaine or Botulinum toxin A injection in extraocular muscles. Myosin heavy chain isoform transitions towards slower isoforms have been found in the experiment (i), however, the relative amount of the slow MHC-1 isoform, was nonsignificantly increased in stimulated Marcaine injected EDL muscles compared to stimulated control muscles. After fast nerve transposition to the slow muscle (ii) expression of MHC isoforms has been shifted toward faster isoforms. In Marcaine injected muscles contrary to noninjected muscles even MHC-2b was expressed. Thyroid hormone status (iii) evidently influenced MHC isoform expression in control and transplanted muscles: in euthyroid conditions the transplanted slow soleus expressed all fast MHC isoforms. MHC-isoform pattern became even more similar to that of fast EDL in hyperthyroid condition and the similarity was less evident in hypothyreoid conditions. Neither regeneration nor recovery of extraocular muscles exposed for one to two years to Marcaine and Botulinum toxin A injection respectively, (iv) could reach the MHC isoform pattern of control extraocular muscles. This points to possible longterm and permanent injuries, caused with Marcaine or Botulinum toxin A injection in clinical practise. By histochemical determination of fibre types in a comparable group tensiomyography has been proved to reflect the percentage of slow type 1 fibres in skeletal muscles. The method is non-invasive and fast. We have developed a method for 3-D reconstruction of the capillary network in skeletal muscles. The mouse levator auris longus muscle has been described as a homogeneous fast muscle, a convenient preparation to study nerve and muscle plasticity.
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