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Projects / Programmes source: ARIS

Sinteze in transformacije organskih spojin, novi reagenti, stereoselektivne in regioselekti (Slovene)

Periods
Research activity

Code Science Field Subfield
1.04.00  Natural sciences and mathematics  Chemistry   

Code Science Field
P390  Natural sciences and mathematics  Organic chemistry 
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  16336  PhD Urška Bratušek  Chemistry  Researcher  2001 - 2003  32 
2.  18867  PhD Lucija Jukić Soršak  Chemistry  Researcher  2001 - 2003  31 
3.  17140  Tončka Kozamernik-Hudeček    Researcher  2001 - 2003 
4.  20062  PhD Renata Osolnik  Chemistry  Researcher  2001 - 2003  69 
5.  21341  PhD Samo Pirc  Chemistry  Researcher  2001 - 2003  40 
6.  19114  PhD Simon Rečnik  Chemistry  Researcher  2001 - 2003  78 
7.  00868  PhD Branko Stanovnik  Chemistry  Head  2001 - 2003  1,884 
8.  08284  PhD Jurij Svete  Chemistry  Researcher  2001 - 2003  931 
9.  17142  Tatjana Toporiš Stipanovič    Researcher  2001 - 2003 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,426 
Abstract
In connection with this research program, the syntheses and transformations of 2-substituted 3-dimethylaminopropenoates and related compounds, masked amino and hydroxy acids are studied, as versatile reagents for the preparation of heterocyclic systems, heteroaryl substituted amino acids, didehydro amino acids and their derivatives and as reagents for the protection of amino and hydroxy groups. Research efforts are concentreted on the development of the synthetic metods for preparation of alkyl 3,4.disubstituted and 1-acyl-3,4-disubstituted pyrrole-2-carboxylates, pirrolo(3,2-d)pyrimidines, 4H-pyrido(1,2-a)pyrimidines, 5H-pyrimidol(1,2-a)pyridazin-4-ones,quinolizinones, benzopyran-2-ones, trisubstituted pyrroles, imidazoles, 1,2,4-oxadiazoles,etc. Selective elimination of protection by catalytic transfer hydrogenation producesfree amino and hydroxy substituted heterocyclic compounds. Second part of investigations is dealing with the synthesis and transformation of chiral compounds with a determined configuration. In this connection the oxidative ring opening of substituted (2R,3R,5S) pyrazolo(1,2-a)pyrazoles afford pyrazolylalanine esters, while by the reductive ring cleavage with Raney nickel substituted alanine amides are formed. Stereoselective amination of 5-substituted lactones and lactames and by application of the "ring switching methodology" quinolizinyl- and pyranonyl-substituted alanine derivatives are formed. Especially the "ring switching methodology" turned out to be a successful method for the preparation of heteroaryl substituted amino and hydroxy acids, polyols, amines and many other chiral compounds with known an predictable configuration.
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Most important socioeconomically and culturally relevant results Final report
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