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Projects / Programmes source: ARIS

Mehanske lastnosti celičnih membran in celični procesi (Slovene)

Periods
January 1, 1999 - December 31, 2003
Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   
1.02.00  Natural sciences and mathematics  Physics   

Code Science Field
B120  Biomedical sciences  Molecular biophysics 
B130  Biomedical sciences  Physiological biophysics 
P340  Natural sciences and mathematics  Lipids, steroids, membranes 
Evaluation (rules)
source: COBISS
Researchers (15)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  18078  Vesna Arrigler    Researcher  2001 - 2003  31 
2.  08588  PhD Urška Batista  Neurobiology  Researcher  2001 - 2003  106 
3.  18326  PhD Jure Derganc  Neurobiology  Researcher  2001 - 2003  113 
4.  18383  Dušan Dragaš    Researcher  2001 - 2003 
5.  18038  PhD Gregor Gomišček  Physics  Researcher  2001 - 2003  91 
6.  15575  PhD Daša Grabec  Oncology  Researcher  2001 - 2003  54 
7.  18384  Marijan Kozamernik    Researcher  2001 - 2003 
8.  05916  PhD Veronika Kralj Iglič  Neurobiology  Researcher  2001 - 2003  875 
9.  18355  PhD Drago Kuzman  Physics  Researcher  2001 - 2003  64 
10.  12001  PhD Janja Majhenc  Physics  Researcher  2001 - 2003  73 
11.  12531  PhD Primož Peterlin  Oncology  Researcher  2003  133 
12.  05488  PhD France Sevšek  Medical sciences  Researcher  2001 - 2003  221 
13.  02013  PhD Saša Svetina  Neurobiology  Head  2001 - 2003  556 
14.  05919  PhD Sonja Vrhovec  Neurobiology  Researcher  2001 - 2003  38 
15.  01068  PhD Boštjan Žekš  Neurobiology  Researcher  2001 - 2003  644 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,524 
Abstract
Shapes of axially strained axisymmetric phospholipid vesicles were studied. The phase diagram for stable prolate shapes was obtained for vesicles with and without equatorial mirror symmetry. At high enough force the stable shapes do not have such a symmetry. The results show that the currently accepted model for the description of lipid-bilayer elasticity (generalized bilayer couple model) properly accounts for the formation of membrane tethers under these conditions. The effect of membrane inclusions on vesicle shapes was also studied. A phenomenological model for the curvature and orientation dependent interaction of an inclusion with the rest of the membrane was developed. It was demonstrated that anisotropic membrane inclusions may stabilize vesicle shapes involving narrow necks. Lamprey erithrocytes were studied in collaboration with the Abo Akademie University. The non-axisymmetrical shape of these cells was interpreted on the basis of the relatively low membrane content of band 3 proteins. The lack of the membrane skeleton in microvesicles which are formed under the effect of detergents on human erythrocytes was interpreted on the basis of the accompanying shear deformation of the skeleton. Effects of the encapsulation of vectamidin vesicles into the erythrocyte membrane on the cell shape were investigated. The occurrence of torocytic endovesicles in erythrocytes under the presence of octaetilenglycol was interpreted on the basis of the curvature dependent binding of this compound to the erythrocyte membrane.
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