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Projects / Programmes source: ARIS

Farmakologija - eksperimentalna (Slovene)

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Periods
January 1, 1999 - December 31, 2003
Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B740  Biomedical sciences  Pharmacological sciences, pharmacognosy, pharmacy, toxicology 
B550  Biomedical sciences  Gastro-enterology 
B530  Biomedical sciences  Cardiovascular system 
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
B650  Biomedical sciences  Psychiatry, clinical psychology, psychosomatics 
B540  Biomedical sciences  Respiratory system 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (16)
no. Code Name and surname Research area Role Period No. of publications
1.  19127  PhD Maja Arh  Neurobiology  Researcher  2001 - 2003  10 
2.  19128  PhD Matevž Arko  Neurobiology  Researcher  2001 - 2003  27 
3.  02740  PhD Metka Budihna  Neurobiology  Head  2001 - 2003  202 
4.  10990  PhD Katarina Černe  Neurobiology  Researcher  2001 - 2003  104 
5.  09096  Silvije Černelč  Neurobiology  Researcher  2001 - 2003  15 
6.  17939  Nevenka Dolžan    Researcher  2001 - 2003  0 
7.  13310  PhD Gorazd Drevenšek  Neurobiology  Researcher  2001 - 2003  329 
8.  17937  Matjaž Hrovat    Researcher  2001 - 2003  0 
9.  02902  PhD Tatjana Irman Florjanc  Neurobiology  Researcher  2001 - 2003  91 
10.  17940  Marjetka Jakomin    Researcher  2001 - 2003  0 
11.  01549  MSc Ladislav Korošec  Neurobiology  Researcher  2001 - 2003  53 
12.  17936  Mojca Kranjec    Researcher  2001 - 2003  0 
13.  21348  PhD Urša Mohar  Pharmacy  Researcher  2001 - 2003  7 
14.  17938  Petra Ponebšek    Researcher  2001 - 2003  0 
15.  17932  Sonja Rozman    Researcher  2001 - 2003  0 
16.  01547  PhD Lavrencij Stanovnik  Neurobiology  Researcher  2001 - 2003  112 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,236 
Abstract
Equinatoxin (EqT-II) contracted coronary arteries in isolated hearts of guinea-pigs, rats and pigs. This effect depended on Ca2+ and Mg2+ concentration. Ca2+ antagonist decreased these effects and the CaCl2-induced contraction of isolated porcine coronary and human tibial artery. The prevailing of L-type over T-type Ca2+ channels in the wall of both arteries was shown. On the isolated porcine coronary artery we proved the involvement of Ca2+ channels in the effects of the whole bee-venom. In the postischaemic damage in rat heart T-type Ca2+ channels are more important than L-type. The preventive role of Ca2+ antagonist has been shown in isolated hearts of guinea-pigs with acute renal failure. The analytical method of non-linear dynamics confirmed that chaotic measures could be used in classifying long term continuous arrhythmias. The test of non-linearity showed that some types of ventricular fibrillation had characteristics of non-linear, and others of stochastic dynamics. The planparallel method was used to determine the thermal conductivity of different parts of porcine heart tissue at different temperatures. EqT-II was found to be an efficient histamine releaser from mast cells, isolated from the rat peritoneal cavity eluent. In the experiments (on cats and rats, in vivo and in vitro), amitriptiline diminished the rise of free exogenous and/or released histamine in plasma, the finding that complemented our previous results. In the study of the effects of histamine antagonists on histamine kinetics in the cat, fexofenadin most efficiently changed histamine kinetics. The parameters of concentration-response relationship for histamine and pA2 value for famotidine on the isolated guinea pig atrium and isolated part of guinea pig stomach were significantly different; the result was explained by nonequilibrium conditions in the stomach preparation. In the guinea pig isolated trachea, depletion of mast cell histamine stores diminished the contractile effect of muscarinic agonist, indicating the involvement of endogenous histamine in the effect, elicited by muscarinic stimulation. The experimental results were shown in international congresses in Budapest, in Lyon and in Gozd Martuljek (Life Sciences). Our group collaborates with research groups in Innsbruck, Graz and Stockholm.
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