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Projects / Programmes source: ARIS

Celična in tkivna elektrotehnika (Slovene)

Periods
Research activity

Code Science Field Subfield
2.06.00  Engineering sciences and technologies  Systems and cybernetics   

Code Science Field
T115  Technological sciences  Medical technology 
T190  Technological sciences  Electrical engineering 
B001  Biomedical sciences  General biomedical sciences 
Evaluation (rules)
source: COBISS
Researchers (13)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15620  PhD David Cukjati  Systems and cybernetics  Researcher  2001 - 2003  54 
2.  17749  Olga Čoga    Researcher  2001 - 2003 
3.  14772  PhD Tomaž Jarm  Systems and cybernetics  Researcher  2001 - 2003  217 
4.  18619  PhD Maša Kandušer  Pharmacy  Researcher  2001 - 2003  162 
5.  15675  PhD Tadej Kotnik  Systems and cybernetics  Researcher  2001 - 2003  208 
6.  12537  PhD Alenka Maček - Lebar  Systems and cybernetics  Researcher  2001 - 2003  224 
7.  10268  PhD Damijan Miklavčič  Systems and cybernetics  Head  2001 - 2003  1,514 
8.  17750  Zdenka Oven    Researcher  2001 - 2003 
9.  19229  PhD Marko Puc  Computer intensive methods and applications  Researcher  2001 - 2003  26 
10.  03074  PhD Stanislav Reberšek  Systems and cybernetics  Researcher  2001 - 2003  157 
11.  17751  Jožica Trobec Gračanin    Researcher  2001 - 2003 
12.  20182  PhD Katja Trontelj  Systems and cybernetics  Researcher  2001 - 2003  20 
13.  17126  Janez Žigon    Researcher  2001 - 2003 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  1538  University of Ljubljana, Faculty of Electrical Engineering  Ljubljana  1626965  28,019 
Abstract
Application of electromagnetic fields on living cells and tissues alters their biological functions. The response depends on parameters of applied electromagnetic field, characteristics of cell or tissue and other factors like temperature, density of cell suspension or culture, etc. Application of external electric field is used in medicine for therapeutic purposes (ventricular defibrillation of the heart) and was shown that it has beneficial effects on wound healing acceleration and tumour growth retardation. The response of living cell on application of external electric field depend on: amplitude, direction, and duration of applied field. The cell responds to electric field by motion, orientation, rotation, and if the certain threshold value is exceeded cell membrane is permeabilized. This phenomenon is known as electropermeabilization or electroporation. Electroporated cell membrane becomes permeable to otherwise unpermeant molecules in its surroundings. The aim of proposed research project is to study the effects electromagnetic fields on cellular and tissues level. On cellular level (in vitro) our study will focus on electropermeabilization of cell membrane. Effects of different parameters like amplitude, duration, number of pulses, frequency of pulse repetition in the train and pulse shape will be studied. All experimental results will be evaluated with numerical dosimetry and theoretical calculations of distribution of electromagnetic field. On tissue level (in vivo) our study will focus on the effect of electric current on perfusion and oxygenation. Both are important parameters of metabolic changes in observed tissue. New non invasive optical techniques will be used in this study. All experimental results will be evaluated by numerical calculations of current density in tissue. Measurements with optical methods will be evaluated with numerical calculations of light transport in different tissues.
Most important scientific results Final report
Most important socioeconomically and culturally relevant results Final report
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