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Projects / Programmes source: ARIS

Plasticity and regeneration of the nervous system and muscles

Periods
Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B210  Biomedical sciences  Histology, cytochemistry, histochemistry, tissue culture 
B580  Biomedical sciences  Skeleton, muscle system, rheumatology locomotion 
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
B740  Biomedical sciences  Pharmacological sciences, pharmacognosy, pharmacy, toxicology 
Evaluation (rules)
source: COBISS
Researchers (19)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  19627  Ksenija Babič Benedik    Researcher  2001 - 2003 
2.  15151  PhD Fajko Bajrović  Neurobiology  Researcher  2002 - 2003  335 
3.  10428  PhD Mara Bresjanac  Neurobiology  Researcher  2001 - 2003  247 
4.  08053  PhD Nevenka Črne-Finderle  Neurobiology  Researcher  2001 - 2003  61 
5.  05921  Dušanka Čuček  Neurobiology  Researcher  2001 - 2003 
6.  21621  Mateja Drolec-Novak    Researcher  2001 - 2003 
7.  18324  PhD Gordana Glavan  Neurobiology  Researcher  2001 - 2003  144 
8.  17921  Darinka Javornik    Researcher  2001 - 2003 
9.  17922  Helena Kupšek    Researcher  2001 - 2003 
10.  17923  Vanja Mavrin    Researcher  2001 - 2003 
11.  20342  PhD Nataša Milivojevič  Neurobiology  Researcher  2001 - 2003  61 
12.  17924  Boris Pečenko    Researcher  2001 - 2003 
13.  07090  PhD Mara Popović  Neurobiology  Researcher  2001 - 2003  306 
14.  18323  PhD Peter Pregelj  Psychiatry  Researcher  2001 - 2003  364 
15.  08010  PhD Samo Ribarič  Neurobiology  Researcher  2001 - 2003  305 
16.  20408  MSc Metka Rožen  Neurobiology  Researcher  2001 - 2003 
17.  01086  PhD Dušan Sket  Neurobiology  Researcher  2001 - 2003  222 
18.  04412  PhD Janez Sketelj  Neurobiology  Head  2001 - 2003  318 
19.  08289  PhD Marko Živin  Neurobiology  Researcher  2001 - 2003  232 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  46,268 
Abstract
Plasticity and regeneration after injury in excitable tissues will be studied in the central nervous system, peripheral nerves and in skeletal muscles. Plasticity in the basal brain nuclei will be examined in several directions: A) animal models for neurodegenerative diseases (Parlinson’s and Huntington’s disease) will be used to investigate the role of interactions between different dopamine receptors, and the substance LEK-8829 will be tested as a possible antipsychotic drug. B) The importance of oxydative stress in neurodegenerative processes in the basal ganglia will be explored. C) Short-term and long-term molecular mechanisms involved in receptor sensitisation/desensitisation and their relationship to psychotropic drug abuse will be investigated. D) Mechanisms of induced plasticity and regeneration in the central nervous system will be investigated as well as ways how to modify these processes to contribute to functional recovery after brain injury. Different animal models and neurotransplantation will be used and the effects of experimental procedures will be analysed by behavioural testing, immunohistochemistry, receptor binding studies and molecular biology techniques. In the investigations of the peripheral nerve injury, possible triggering factors for collateral sprouting of axons will be explored. We will study sensory axon regeneration in the injured nerve in the absence of cell support in the nerve segment distally to the lesion site and possible effects of prior collateral sprouting or application of different trophic factors on such regeneration. In the studies of muscle plasticity, the effects of different stimulation patterns, denervation and paralyisis will be examined in more detail. In addition, the effects of thyroid hormones and muscle load on acetycholinesterase will be investigated. We will also try to develop a method for continuous chronic registration and analysis of bioelectric potentials (EMG, EEG) in freely moving experimental animals. Plasticity and regeneration are the most important processes responsible for functional recovery after injury to excitable tissues. Therefore, new knowledge in this field may on a long run contribute to improvement of therapeutic approaches in neurology and psychiatry.
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