Projects / Programmes source: ARIS

Study of electrophysiological, morphological, pharmacological and biochemical characteristics of heart in models and in heart surgery procedures

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B530  Biomedical sciences  Cardiovascular system 
electrophysiology, atrial fibrillation, variable heart frequency, ischemia, reperfusion, brain nerve peptide (BNP)
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  02498  MSc Aleš Brecelj  Cardiovascular system  Researcher  2002 - 2004  75 
2.  02740  PhD Metka Budihna  Neurobiology  Researcher  2002 - 2004  202 
3.  13310  PhD Gorazd Drevenšek  Neurobiology  Researcher  2002 - 2004  328 
4.  02260  PhD Tone Gabrijelčič  Cardiovascular system  Researcher  2002 - 2004  103 
5.  04768  PhD Borut Geršak  Cardiovascular system  Head  2002 - 2004  343 
6.  00814  PhD Ksenija Geršak  Human reproduction  Researcher  2002 - 2004  522 
7.  21172  PhD Jurij Matija Kališnik  Cardiovascular system  Researcher  2002 - 2004  149 
8.  09160  PhD Peter Rakovec  Cardiovascular system  Researcher  2002 - 2004  395 
9.  20713  PhD Silvia Samarin Lovrič  Cardiovascular system  Researcher  2002 - 2004  22 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  75,496 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  45,382 
Decreased Heart rate variability (HRV) indexes have been associated with higher mortality in coronary patients, and may predispose those patients with higher propensity to lethal arrhythmias. Data reporting on sequential changes of HRV indexes after cardiac operations are modest and show considerable inconsistency. The impairment of cardiac autonomous dysfunction may vary according to the severity of ischaemia. Temporal recovery pattern of HRV measures will be determined. The severity of cardiac sympathoparasympathetic dysfunction will be assessed in patients undergoing beating heart and non-beating heart surgery. With non-invasive measurement of modified surface ECG leads we will evaluate some electrocardiographic markers with correlation to different heart diseases. We will try to elucidate mutual influence between different markers and their possbile dependence from autonomic nervous stimuli and the frequency of breathing. We will study dispersion and variability of ECG markers and heart rate variability. During the heart surgery we will perform an additional procedure with patients having atrial fibrillation. Special catheter for endocardial and epicardial ablation (lesion) will be used for treatment of atrial fibrillation. During heart surgery we will collect blood samples in different time intervals. Ischaemic serum markers and BNP (brain natriuretic peptide) will be analyzed. The latter could be a long-term predictor of the heart surgery outcome. We will estimate the degree of intraoperative myocardial ischaemic damage and compare two types of operations according to intraoperative myocardial protection, postoperative therapy of patients and their long-term prognosis. In laboratory models vessels and endothelium, we will try to evaluate possible gender differences in arising of ischemic injuries. We will use isolated animal hearts, vessels and endothelium as well as some human tissues obtained during heart surgery, treated with selected drugs and exposed to ischemia and reperfusion. We will try to evaluate some physiological, pharmacological and biochemical differences in gender related differences of myocardial injuries.
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