Projects / Programmes
Study of electrophysiological, morphological, pharmacological and biochemical characteristics of heart in models and in heart surgery procedures
| Code |
Science |
Field |
Subfield |
| 3.06.00 |
Medical sciences |
Cardiovascular system |
|
| Code |
Science |
Field |
| B530 |
Biomedical sciences |
Cardiovascular system |
electrophysiology, atrial fibrillation, variable heart frequency, ischemia, reperfusion, brain nerve peptide (BNP)
Researchers (9)
Organisations (2)
Abstract
Decreased Heart rate variability (HRV) indexes have been associated with higher mortality in coronary patients, and may predispose those patients with higher propensity to lethal arrhythmias. Data reporting on sequential changes of HRV indexes after cardiac operations are modest and show considerable inconsistency. The impairment of cardiac autonomous dysfunction may vary according to the severity of ischaemia. Temporal recovery pattern of HRV measures will be determined. The severity of cardiac sympathoparasympathetic dysfunction will be assessed in patients undergoing beating heart and non-beating heart surgery.
With non-invasive measurement of modified surface ECG leads we will evaluate some electrocardiographic markers with correlation to different heart diseases. We will try to elucidate mutual influence between different markers and their possbile dependence from autonomic nervous stimuli and the frequency of breathing. We will study dispersion and variability of ECG markers and heart rate variability.
During the heart surgery we will perform an additional procedure with patients having atrial fibrillation. Special catheter for endocardial and epicardial ablation (lesion) will be used for treatment of atrial fibrillation.
During heart surgery we will collect blood samples in different time intervals. Ischaemic serum markers and BNP (brain natriuretic peptide) will be analyzed. The latter could be a long-term predictor of the heart surgery outcome. We will estimate the degree of intraoperative myocardial ischaemic damage and compare two types of operations according to intraoperative myocardial protection, postoperative therapy of patients and their long-term prognosis.
In laboratory models vessels and endothelium, we will try to evaluate possible gender differences in arising of ischemic injuries. We will use isolated animal hearts, vessels and endothelium as well as some human tissues obtained during heart surgery, treated with selected drugs and exposed to ischemia and reperfusion. We will try to evaluate some physiological, pharmacological and biochemical differences in gender related differences of myocardial injuries.
