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Projects / Programmes source: ARIS

Ecg repolarisation changes in patients with multiple system atrophy and in patients with diabetic autonomic neuropathy.

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Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
Keywords
Autonomic nervous system, ECG, repolarisation changes, multiple system atrophy, diabetes.
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (7)
no. Code Name and surname Research area Role Period No. of publications
1.  17692  Franci Benko    Researcher  2002 - 2004  0 
2.  10693  PhD Jan Kobal  Neurobiology  Researcher  2002 - 2004  144 
3.  10679  MSc Bernard Meglič  Neurobiology  Researcher  2002 - 2004  135 
4.  05298  PhD Anton Mesec  Neurobiology  Head  2002 - 2004  150 
5.  05380  PhD Zvezdan Pirtošek  Neurobiology  Researcher  2002 - 2004  745 
6.  06739  PhD Marjeta Tomažič  Metabolic and hormonal disorders  Researcher  2002 - 2004  113 
7.  17693  Anka Žekš    Researcher  2002 - 2004  0 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,458 
Abstract
Autonomic dysfunction can occur in many diseases of the central and peripheral nervous system. Impairments of the autonomic system are difficult to assess and measure. Among various methods, the most established is non-invasive assessment of cardiovascular refexes using a precise registration of blood pressure and heart frequency change. Basic studies and analysis of myocardial repolarisation parameters (QT interval length, QT dispersion) showed that repolarisation depends also on the heart autonomic innervation. The role of sympathetic and parasympathetic system remains unclear. Early discovery of impairments in repolarisation may prevent subsequent complications. Two groups of patients with a possible autonomic impairment at different levels will be included in our study. Impairment in patients with MSA is central, whereas impairment in patients with diabetes is peripheral. In all participants classical cardiovascular reflexes will be assessed and 12- & 35-channel ECG will be recorded. The myocardial repolarisation parameters (QTc, QT temporal and spatial dispersion) will be calculated from the ECG traces. We will study differences in autonomic cardiac dysfunction in MSA vs. diabetes and impairments in depolarisation which may reflect autonomic dysfunction. We will compare suitability of both methods in detecting autonomic dysfunction.
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