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Projects / Programmes source: ARIS

Role of oocyte freezing in the treatment of infertile couple

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Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   

Code Science Field
B450  Biomedical sciences  Development biology, teratology, ontogeny, embryology (human) 
B570  Biomedical sciences  Obstetrics, gynaecology, andrology, reproduction, sexuality 
Keywords
human oocytes, freezing, thawing, ICSI, fertilization, pregnancy
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (13)
no. Code Name and surname Research area Role Period No. of publications
1.  15071  Liljana Bačer Kermavner  Human reproduction  Researcher  2002 - 2003  93 
2.  10568  Sašo Drobnič  Human reproduction  Researcher  2002 - 2003  137 
3.  00814  PhD Ksenija Geršak  Human reproduction  Researcher  2002 - 2003  531 
4.  19982  Antonija Gorše    Researcher  2002 - 2003  0 
5.  17637  Ana Kisel Vovko    Researcher  2002 - 2003  3 
6.  20258  MSc Robert Medved  Human reproduction  Researcher  2002 - 2003  27 
7.  17644  Jožica Mivšek    Researcher  2002 - 2003  65 
8.  05274  PhD Martina Ribič Pucelj  Human reproduction  Researcher  2002 - 2003  490 
9.  19983  Janja Tekavec    Researcher  2002 - 2003  0 
10.  07007  PhD Tomaž Tomaževič  Human reproduction  Researcher  2002 - 2003  653 
11.  12245  Alenka Veble  Human reproduction  Researcher  2002 - 2003  71 
12.  06087  PhD Irma Virant Klun  Human reproduction  Head  2002 - 2003  522 
13.  19449  PhD Branko Zorn  Human reproduction  Researcher  2002 - 2003  307 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,465 
Abstract
In programme of assissted reproduction, we will introduce the method of oocyte freezing and thawing. After hormonal ovarian stimulation or in natural cycle we will retrieve and freeze oocytes in women with first symptoms of ovarian function failure (pre-mature menopause) and before oncotherapy (chemotherapy, radiotherapy). Oocytes will be long-term stored and in this way the reproductive function of women will be kept. In the future in vitro fertilization of her owen oocytes will be performed, and the need for donnor oocytes will be decreased. Oocytes will be frozen also in couples included in the programme of in vitro fertilization. In couples with no semen obtained because of male psychological and physiological troubles on the day of in vitro fertilization all oocytes will be frozen and fertilization will be performed on thawed oocytes after semen retrieval. Similarly, all oocytes will be frozen on the day of in vitro fertilization if no spermatozoa will be found in semen or testicular tissue. After male treatment and retrieval of ejaculate, testicular, or epididymal spermatozoa, oocytes will be thawed and in vitro fertilization performed. The possibility of oocyte cryopreservation and in vitro fertilization on thawed oocytes will be offered to elderly women (> 36 years) and to women with more than 15 retrieved oocytes to improve the cummulative success (fertilization, achievement of pregnancy) of in vitro fertilization. In all cases, oocytes will be frozen slow, automatically (programmatic) or quick by vitrification. On frozen-thawed oocytes intracytoplasmic sperm injection (ICSI) will be performed. Embryos will be tested genetically by preimplantation genetic diagnosis and transfered to the uterus in a natural cycle or after mild hormonal preparation. We will try to improve the implantation potential of embryos by the method of "assisted hatching". We will compare the results of in vitro fertilization obtained by fresh or frozen-thawed oocytes (fertilization, achievement of pregnancy), and evaluate the cummulative success of in vitro fertilization progrmme. We will evaluate the biological quality of thawed oocytes (mitotic spindle) in comparison with fresh oocytes. We will evaluate factors affecting the success of oocyte freezing and thawing progrmme (female age, indications of infertility, ovarian stimulation). The project is scientifically original and very important for the clinical practice.
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