Filters
cris logo
-
New search Filters
Select from list
Displayed from Show more
You have reached the maximum number of displayed search results.
All results displayed
No results are available for the search performed
Displayed from
You have reached the maximum number of displayed search results.
All results displayed
Loading results
Obtaining statistical data

Projects / Programmes source: ARIS

Role of homocistein in remodeling of cardiovacular system

Edit
Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B530  Biomedical sciences  Cardiovascular system 
Keywords
Homocistein, left ventricular mass, intima-media thickness, remodeling
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (3)
no. Code Name and surname Research area Role Period No. of publications
1.  07491  MSc Primož Dolenc  Cardiovascular system  Researcher  2002 - 2004  191 
2.  11154  MSc Barbara Salobir  Cardiovascular system  Researcher  2002 - 2004  59 
3.  04421  PhD Aleš Žemva  Cardiovascular system  Head  2002 - 2004  168 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,499 
Abstract
Cardiovascular diseases remain the major cause of death in developed countries. In addition to major risk factors, raised plasma homocistein was found to increase the risk of cardiovascular diseases. A plethora of mechanisms have been suggested whereby raised homocistein levels may cause vascular disease. These include platelet activation, enhanced coagulation, oxidation of low density lipoproteins, endothelial dysfunction and proliferation of vascular smooth muscle cells. So far these adverse effects of elevated homocistein have been evaluated in experimental conditions (in cell models) only, while no reliable clinical data are available. Therefore we decided to study the relationship of hyperhomocisteinemia to intima-media thickness of common carotid artery and to left ventricular mass in patients with and without convetional risk factors such as hypercholesterolemia, hypertension and diabetes. Our hypothesis is, that clinical investigative tools (cardiac and vascular ultrasound) will reveal morphological changes, which so far have been described in experimental (cellular) models. Six groups (each including 30 subjects) will be evaluated. First group: subjects with elevated homocistein but without additional risk factors. Second group: subjects with hypertension. Third group: subjects with hypercholesterolemia. Fourth group: subjects with diabetes mellitus. Fifth group: subjects with renal failure. Sixth group: healthy control subjects. In all subjects homocistein in plasma will be measured by fluorescent polarisation immunological assay. To measure left ventricular mass and intima-media thickness, cardiac and vascular ultrasound will be performed respectively. Cholesterol, glucose, hemoglobin A1c and creatinin will be measured by convetional methodes. Blood pressure will be evaluated by 24-h blood pressure monitoring. To evaluate the predictive value of homocistein and other risk factors for left ventricular mass and intima-media thickness of carotid artery, multiple regression analysis will be performed.
Confirmation required
Views history
Favourite