Projects / Programmes
Human papilloma viruses (HPV) 16 and 18 in patients with cervical intraepithelial neoplasia
| Code |
Science |
Field |
Subfield |
| 3.04.00 |
Medical sciences |
Oncology |
|
| Code |
Science |
Field |
| B570 |
Biomedical sciences |
Obstetrics, gynaecology, andrology, reproduction, sexuality |
cervical intraepithelial neoplasia, human papillomavirus, infection
Researchers (4)
| no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
| 1. |
20133 |
Nina Čas Sikošek |
Oncology |
Researcher |
2002 - 2004 |
85 |
| 2. |
03457 |
PhD Borut Gorišek |
Oncology |
Researcher |
2002 - 2004 |
254 |
| 3. |
05332 |
Tatjana Kodrič |
Oncology |
Researcher |
2002 - 2004 |
84 |
| 4. |
01324 |
PhD Iztok Takač |
Human reproduction |
Head |
2002 - 2004 |
911 |
Organisations (1)
Abstract
In Slovenia, the number of patients with cancer of the uterine cervix has been increasing during last years. In the year 1997, 236 new cases of this disease were registered, giving an extremely high incidence of 23.1 per 100000 women, regarding European environment. Cervical cancer precursor, namely cervical intraepithelial neoplasia (CIN) was registered in 654 cases. The aetiology of CIN development is still unknown, despite knowledge of some factors, which interfere in development and progress of this disease. Among these factors a distinct role is addressed to human papillomaviruses (HPV), particularly types 16 and 18 beeing responsible for uerine cervical oncogenic processess. HPV infection rate differs regarding different geographic and demographic characteristics of the population studied. Also, the infection rate of different degrees of CIN is unknown. Various parts of the uterine cervix and neighbouring structures are affected by HPV. Thus multifocal neoplasia of different parts of the uterine cervix is possible and also the coexistence of various neoplasias of different degrees. This could be negatively reflected in the sense of preoperative determination of the degree of CIN. Namely, in the area where tissue sample was not obtained for histologic evaluation, besides estimated degree of CIN also another, higher degree of CIN could be present. On the other hand, such islands of neoplastic epithelium could adversely affect the radicallity of the surgical procedure and increase the number of so called "not in sano excised specimens", thus demanding further closer follow-up and treatment of these patients. The aims of the present study are to evaluate the frequency of HPV 16 and 18 infection in our patients with different grades of CIN, to assess the role of HPV infection in the accuracy of preoperative determination of CIN and its impact on the radicallity of the surgical procedure. In the prospective study we intend to include 300 patients with proven diagnosis of CIN, in whom the presence of HPV 16 and 18 infection of the uterine cervix will be evaluated. After the surgical procedure, the viral infection rate in different degrees of CIN will be determined. We will try to find out if the viral infection has a significant impact regarding the accuraccy of preoperative determination of the degree of CIN, as well as regarding the completeness of the excision of the neoplastic process.
