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Projects / Programmes source: ARIS

Development of probiotic preparations - study of functional properties "in vitro" and "in vivo"

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Research activity

Code Science Field Subfield
4.02.00  Biotechnical sciences  Animal production   

Code Science Field
B230  Biomedical sciences  Microbiology, bacteriology, virology, mycology 
B400  Biomedical sciences  Zootechny, animal husbandry, breeding 
B420  Biomedical sciences  Nutrition 
Keywords
probiotics, lactic-acid bacteria, human isolates, Lactobacillus acidophilus, lactobacilli, RAPD, PCR, feed supplement, pigs, healthy food, milk
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (5)
no. Code Name and surname Research area Role Period No. of publications
1.  11150  PhD Bojana Bogovič Matijašić  Animal production  Head  2002 - 2004  394 
2.  15659  PhD Andreja Čanžek Majhenič  Animal production  Researcher  2002 - 2004  244 
3.  05099  PhD Karmen Godič Torkar  Microbiology and immunology  Researcher  2002 - 2004  263 
4.  06375  Vanja Penca Habjan  Animal production  Researcher  2002 - 2004  16 
5.  21439  PhD Saša Stojković  Biotechnology  Researcher  2002 - 2004  15 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  66,844 
Abstract
Probiotics represent a possible alternative for the use of antibiotics as a feed supplement and in human nutrition in prevention or even in therapy of some diseases. Human bacterial isolates K7 and LF221 from Lactobacillus acidophilus group fulfil basic criteria for probiotic strains, produce bacteriocins with wide spectra of activity and are able to inhibit selected pathogenic bacteria. Study of the gut colonisation and of some functional effects (impact on faecal microflora composition, weight gain, general health state, nuclear DNA damage) will be performed on 24 weaned piglets. A combination of conventional microbiological and molecular-genetic methods (RAPD, PCR) will be applied for the tracing of a particular strain in mixed bacterial population of faeces. New isolates of lactic acid bacteria interesting for future use in species-specific probiotic preparations for animals will be obtained as well. Functional properties (adhesion, invasion) of both strains which are important from the point of view of safety and efficiency of human probiotics will be studied on human cell lines. The suitability of different media like cheese, milk or whey for the growth and survival of test probiotic bacteria and as a food vehicles will be tested. Their survival during drying ("spray-dry", "fluid-bed") will be examined as well. The results obtained will be useful for the development of probiotic preparations suitable for animal or human application.
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