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Projects / Programmes source: ARIS

Determination of surface properties of solid and semisolid materials by solid and semisolid materials with inverse phase gas chromatography

Research activity

Code Science Field Subfield
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
T130  Technological sciences  Production technology 
Keywords
inverse phase gas chromatography, surface energy, nonpolar properties of surfaces, acid properties of surfaces, base properties of surfaces , crystalinity, amorphicity, interfacial interactions
Evaluation (rules)
source: COBISS
Researchers (10)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15490  PhD Pegi Ahlin Grabnar  Pharmacy  Researcher  2003 - 2005  213 
2.  15104  PhD Saša Baumgartner  Pharmacy  Researcher  2003 - 2005  306 
3.  21455  PhD Rok Dreu  Pharmacy  Researcher  2003 - 2005  292 
4.  11733  PhD Matjaž Kunaver  Materials science and technology  Researcher  2003 - 2005  339 
5.  15792  PhD Ida Mav Golež  Chemistry  Researcher  2003 - 2005  38 
6.  12443  PhD Irena Mlinarič Raščan  Pharmacy  Researcher  2003 - 2005  534 
7.  14935  PhD Odon Planinšek  Pharmacy  Researcher  2003 - 2005  440 
8.  09031  PhD Stanko Srčič  Pharmacy  Head  2003 - 2005  675 
9.  22309  PhD Natalija Škrbina Zajc  Pharmacy  Researcher  2003 - 2005  43 
10.  09178  PhD Janko Žmitek  Pharmacy  Researcher  2003 - 2005  298 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,316 
2.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,269 
Abstract
Suface properties of solid and semisolid materials will be studied by means of inverse gas chromatography. This is a method that has not been used in Slovenia. There are only a few centers with this equipment in the field of pharmacy (two in United Kingdom) and no one on the continet. In general phamaceutical active and excipients, polymers, foods ingredients, ingredients of paints, meterials used in building and many other industries can be tested by use of inverse gas chromatography. The proposal research will be concentrated only on pharmaceutical ingredients and its aim is the quantitative determination of surface properties of solid and semisolid materials. The surface properties can be expressed as a dispersive and polar part ( Lewis acid and Lewis base ) of surface energy. In addition, interactions between ingredinents ( i.e. in powder mixtures), of the samples could be studied. Surface properties parameters obtained by means of inverse gas chromatography can be used further as a screening test for differentiation between batches and the different suppliers of the same chemical entities thar could be essentially different in physico-technological behaviour. Surface properties can be used therefore for optimal selection of ingredients in pharmaceutical preformulation and formulation study phases.
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