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Projects / Programmes source: ARIS

Genes, hormones and mental changes in metabolic disorders

Periods
Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
B480  Biomedical sciences  Endocrinology, secreting systems, diabetology 
Keywords
osteoporosis, diabetes mellitus, insulin resistance, polycystic ovary syndrome (PCO), intracellular signalling, bone turnover markers, diabetic nephropathy, vitamin D, mental disorders
Evaluation (rules)
source: COBISS
Researchers (22)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  26488  PhD Katica Bajuk Studen  Metabolic and hormonal disorders  Junior researcher  2006 - 2008  105 
2.  26227  Manja Cedilnik    Technical associate  2006 - 2008 
3.  18372  PhD Andrej Janež  Metabolic and hormonal disorders  Researcher  2004 - 2008  665 
4.  03343  PhD Andreja Kocijančič  Metabolic and hormonal disorders  Researcher  2004 - 2005  327 
5.  15783  PhD Tomaž Kocjan  Metabolic and hormonal disorders  Researcher  2004 - 2008  517 
6.  12189  PhD Janja Marc  Metabolic and hormonal disorders  Researcher  2004 - 2008  712 
7.  08205  PhD Marko Medvešček  Metabolic and hormonal disorders  Researcher  2004 - 2008  221 
8.  24475  PhD Simona Mencej Bedrač  Pharmacy  Junior researcher  2006 - 2008  75 
9.  18996  PhD Barbara Mlinar  Pharmacy  Researcher  2004 - 2008  48 
10.  05984  PhD Marija Pfeifer  Metabolic and hormonal disorders  Researcher  2004 - 2008  381 
11.  24466  PhD Draženka Pongrac Barlovič  Metabolic and hormonal disorders  Junior researcher  2008  340 
12.  01989  PhD Janez Preželj  Metabolic and hormonal disorders  Head  2004 - 2008  303 
13.  01993  PhD Maja Ravnik-Oblak  Metabolic and hormonal disorders  Researcher  2004 - 2008  229 
14.  21972  Alenka Roš    Technical associate  2004 - 2008 
15.  00788  PhD Boštjan Salobir  Metabolic and hormonal disorders  Researcher  2004 - 2008  41 
16.  28525  PhD Aleš Skvarča  Metabolic and hormonal disorders  Junior researcher  2008  141 
17.  21971  Elizabeta Stepanovič    Technical associate  2004 - 2008  11 
18.  06739  PhD Marjeta Tomažič  Metabolic and hormonal disorders  Researcher  2004 - 2008  113 
19.  25495  PhD Zoran Trošt  Metabolic and hormonal disorders  Junior researcher  2006 - 2008  30 
20.  12151  PhD Vilma Urbančič-Rovan  Metabolic and hormonal disorders  Researcher  2006 - 2008  219 
21.  01996  PhD Matjaž Vrtovec  Metabolic and hormonal disorders  Researcher  2008  79 
22.  19636  Angelca Zver    Technical associate  2004 - 2008 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,723 
2.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,540 
Abstract
The programme is based on the results of our previous research in the field of osteoporosis, diabetes and polycystic ovary syndrome (PCO). In osteoporosis research the approach will include determinations of local regulators of bone metabolism (osteoprotegerin, RANK, RANKL, interleukine 1, TNF, kathepsin K). Expression of genes relevant to bone metabolism will be measured in bone tissue provided during hip surgery in osteoporotic patients. We hope to provide new insight into pathophysiology of osteoporosis at cellular level. We will proceed with our research in genetics of osteoporosis to get possible predictors of therapy response and of risk for osteoporosis. We will proceed investigation on insulin resistance in AIDS and PCO, trying to get information of possible differences compared to patients with diabetes mellitus type 2. In patients with PCO we plan to follow changes in insulin resistance after therapy with metpformin or rosiglitazone. In patients with diabetes mellitus our research will focus on endothelin, endothelin gene polymorphism and adiponectin and their role in pathogenesis of diabetic nephropathy. The other aspect of diabetes research will include mental disorders in this population. We will screen outpatient population by means of CES-D and SCL90. These tests were not yet used in diabetes mellitus patients.
Significance for science
In the field of osteoporosis our description of new polymorphisms in candidate genes enriched the pool of known genetic variations influencing bone mineral density. We also contributed to the knowledge of how these polymorphisms influence the expression of genes coding for proteins involved in bone metabolism. This knowledge contributes to the unravelling the association between osteoporosis and variations in genotype, phenotype, and lifestyle. The ultimate aim is the development of personalised osteoporosis prevention. In the field of PCOS our programme group was the first to reveal a part of molecular mechanisms for reducing insulin resistance by metformin and rosiglitazon in these patients. In the clinical context we found the positive effect of this treatment on endothelial dysfunction, which is supposed to be an early reflection of vascular atherosclerotic changes in women with PCOS.
Significance for the country
Data obtained by basic medical research rarely result in immediate direct applications. New discoveries and publications in renown international ......contribute to the recognition and reputation of Slovenian medical researchers.
Most important scientific results Final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Final report, complete report on dLib.si
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