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Projects / Programmes source: ARIS

Genes, hormones and personality changes in metabolic disorders

Periods
Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
B480  Biomedical sciences  Endocrinology, secreting systems, diabetology 

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
Key words: genetics, epigenetics, osteoporosis, bone pathology, diabetes type2, diabetes type1, PCOS, insulin resistance
Evaluation (rules)
source: COBISS
Researchers (30)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  26482  PhD Ajda Biček  Metabolic and hormonal disorders  Researcher  2015 - 2018  54 
2.  26227  Manja Cedilnik    Technical associate  2015 - 2018 
3.  18372  PhD Andrej Janež  Metabolic and hormonal disorders  Head  2015 - 2018  665 
4.  32347  PhD Mojca Jensterle Sever  Metabolic and hormonal disorders  Researcher  2015 - 2018  557 
5.  50226  PhD Jasna Klen  Metabolic and hormonal disorders  Researcher  2018  76 
6.  15783  PhD Tomaž Kocjan  Metabolic and hormonal disorders  Researcher  2015 - 2018  517 
7.  38167  PhD Klemen Kodrič  Metabolic and hormonal disorders  Junior researcher  2015 - 2018  15 
8.  33053  PhD Tilen Kranjc  Pharmacy  Researcher  2015 - 2018  53 
9.  19649  PhD Marija Nika Lovšin  Microbiology and immunology  Researcher  2015 - 2018  124 
10.  28865  PhD Mojca Lunder  Cardiovascular system  Researcher  2017 - 2018  144 
11.  12189  PhD Janja Marc  Metabolic and hormonal disorders  Researcher  2015 - 2018  712 
12.  24475  PhD Simona Mencej Bedrač  Pharmacy  Researcher  2015  75 
13.  25809  PhD Vid Mlakar  Metabolic and hormonal disorders  Researcher  2015  96 
14.  39277  Evelina Oltra    Technical associate  2016 - 2018 
15.  18154  PhD Barbara Ostanek  Metabolic and hormonal disorders  Researcher  2015 - 2018  187 
16.  33759  Mirela Ožura    Technical associate  2015 - 2018 
17.  05984  PhD Marija Pfeifer  Metabolic and hormonal disorders  Researcher  2015 - 2017  381 
18.  24466  PhD Draženka Pongrac Barlovič  Metabolic and hormonal disorders  Researcher  2015 - 2018  340 
19.  01989  PhD Janez Preželj  Metabolic and hormonal disorders  Researcher  2015 - 2018  303 
20.  22657  PhD Irena Prodan Žitnik  Pharmacy  Researcher  2018  48 
21.  01993  PhD Maja Ravnik-Oblak  Metabolic and hormonal disorders  Researcher  2015 - 2018  229 
22.  28525  PhD Aleš Skvarča  Metabolic and hormonal disorders  Researcher  2015 - 2018  141 
23.  21971  Elizabeta Stepanovič    Technical associate  2015 - 2018  11 
24.  06739  PhD Marjeta Tomažič  Metabolic and hormonal disorders  Researcher  2015 - 2018  113 
25.  12151  PhD Vilma Urbančič-Rovan  Metabolic and hormonal disorders  Researcher  2015 - 2018  219 
26.  32807  PhD Peter Vrtačnik  Pharmacy  Junior researcher  2015  18 
27.  01996  PhD Matjaž Vrtovec  Metabolic and hormonal disorders  Researcher  2015 - 2017  79 
28.  27897  PhD Jelka Zaletel  Metabolic and hormonal disorders  Researcher  2015 - 2018  643 
29.  32306  PhD Janja Zupan  Metabolic and hormonal disorders  Researcher  2015 - 2018  110 
30.  19635  Barbara Žargaj    Technical associate  2015 - 2018 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,723 
2.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,540 
Abstract
Our programme is based on activities and achievements in the last two decades in the field of chronic metabolic disorders such as osteoporosis and bone metabolism, polycystic ovary syndrome (PCOS), diabetes type 2 (and to a lesser degree type 1) and insulin resistance as a common component of the last two disorders. The majority of our activities will be further research in the directions where we already have results or are trying to get answers on new questions that appeared as a consequence of our results. We will proceed with adding insight in connections between new polymorphisms and bone mineral density (BMD), adding new dependent variables such as fracture risk calculations and indirect estimations of bone microarchitecture (trabecular bone score – TBS). A new topic will be epigenetic research in bone pathology. We intend to broaden our “bone” research to metastatic bone disease and chondrocyte pathology. A connection between bone field and diabetes will be another research topic: messengers in feed-back loops between bone and energy metabolism (cytokines, adipocytokins). Another research topic will be the link between type 1 diabetes and PCOS. In the field of PCOS new therapies with ovary as therapeutic target are planned.
Significance for science
The background of several bone and metabolic disorders is nowadays widely studied, but still poorly understood. In the development of these diseases, several mechanisms are involved and many of them are still not discovered and understood. By studying and explaining the development of the disease, potential new diagnostic and therapeutic targets are being discovered. On the basis of new insights into disease mechanisms, new diagnostic tests could be developed, possibly providing a better, patient-friendlier and more reliable diagnostic and prognostic tool. Additionally, proteins in the signaling pathways could also be used as new therapeutic targets for the development of new active substances. Functionally and clinically relevant miRNAs would represent novel therapeutic targets for the development of new efficient and safe medicines for the treatment.
Significance for the country
Publications in renowned SCI journals, resulting from our research, have many citations in scientific literature, proving the quality of our work and its world-wide recognition. Many doctors and young researchers produce their Ph thesis under the auspices of our programme group. By collaborating with research groups abroad we contribute to the fact that Slovenian research is recognized among the scientists world-wide.
Most important scientific results Annual report 2015, 2016, 2017, final report
Most important socioeconomically and culturally relevant results Annual report 2015, 2016, 2017, final report
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