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Projects / Programmes source: ARRS

Prevention of ischaemic events in patients with peripheral arterial disease - Laboratory markers of ischaemic events

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B530  Biomedical sciences  Cardiovascular system 
Keywords
atherosclerosis, peripheral arterial disease, cardiovascular event, risk factors, haemostasis activation markers, adhesion molecules, inflammation markers, genetic polymorphisms
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  07630  PhD Aleš Blinc  Medical sciences  Researcher  2005 - 2008  480 
2.  15637  PhD Mojca Božič Mijovski  Medical sciences  Researcher  2005 - 2008  199 
3.  08799  Matija Cevc  Medical sciences  Researcher  2005 - 2008  131 
4.  11685  PhD Zlatko Fras  Medical sciences  Researcher  2005 - 2008  762 
5.  05965  PhD Matija Kozak  Medical sciences  Researcher  2005 - 2008  321 
6.  05034  PhD Mojca Stegnar  Medical sciences  Principal Researcher  2005 - 2008  343 
7.  08094  PhD Mirza Šabovič  Medical sciences  Researcher  2005 - 2008  409 
8.  18377  PhD Monika Štalc  Medical sciences  Researcher  2005 - 2008  119 
9.  03392  MSc Viktor Videčnik  Medical sciences  Researcher  2005 - 2008  103 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  73,855 
Abstract
Peripheral arterial disease (PAD) confirmed by reduced ankle-brachial pressure index is associated with increased mortality due to myocardial infarction and ischemic stroke. Studies describe 2 to 3-fold greater mortality in patients with PAD than in age-matched controls with normal ankle-brachial pressure index, with a 5-year mortality of about 30% in patients with advanced PAD. Risk factors for PAD are the same as for coronary heart disease, where they were shown to explain most of the risk for myocardial infarction.. The predictive value of haemostatic and inflammatory markers in patients with PAD is not well established. The study is designed as a prospective comparison of patients with documented PAD and age- and sex-matched controls with normal ankle-brachial pressure index. Both groups will receive recommended cardiovascular preventive measures according to the European Guidelines on Cardiovascular Disease Prevention in Clinical Practice. Primary end-points of the study are major ischemic events: myocardial infarction, ischemic stroke and cardio-vascular death. Secondary end-points are the need for peripheral vascular revascularization, coronary artery revascularization, carotid artery revascularization and the need for repair of abdominal aortic aneurysm. In the study at least 1000 patients with reduced ankle-brachial pressure index (< 0.9) and the same number of age-matched and sex-matched controls with normal ankle-brachial pressure index (0.91 – 1.30) will be investigated. At the initial examination, all subjects will be interviewed on their personal and family history, a physical examination will be performed including anthropometric measurements. Urine will be tested for glucose and albumin. Venous blood will be drawn for routine tests and haemostatic and inflammation markers (fibrinogen, high sensitive CRP, VCAM-1, soluble P-selectin, soluble von Wilebrand factor, D-dimer, polymorphisms in genes for platelet receptors GP IIb/IIIa and Ia/Iia). End-points wiull be recorded in all subjects included. It is expected that that the study will confirm the hypothesis that cardio-vascular ischemic events are more frequent in patients with PAD receiving secondary prevention measures than in age and sex-matched control subjects with normal ankle-brachial pressure index and that haemostatic and inflammatory markers are predictive factors for cardio-vascular ischemic events in patients with PAD.
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