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Projects / Programmes source: ARRS

Ugotavljanje povezave med bakterijo Mycobacterium avium subsp. paratuberculosis pri živalih in Crohnovo boleznijo pri ljudeh (Slovene)

Research activity

Code Science Field Subfield
4.04.00  Biotechnical sciences  Veterinarian medicine   
Evaluation (rules)
source: COBISS
Researchers (21)
no. Code Name and surname Research area Role Period No. of publications
1.  28448  PhD Jana Avberšek  Veterinarian medicine  Junior researcher  2008 - 2011  106 
2.  26229  Tina Bukovec    Technician  2011 
3.  05367  PhD Anton Cerar  Oncology  Researcher  2008 - 2011  194 
4.  17572  PhD Marko Cotman  Veterinarian medicine  Researcher  2008 - 2011  107 
5.  06207  Zvezdana Dolenc-Stražar  Microbiology and immunology  Technician  2008 - 2011  76 
6.  14880  PhD Igor Gruntar  Veterinarian medicine  Researcher  2008 - 2011  107 
7.  06758  PhD Franc Jelenc  Oncology  Researcher  2008 - 2011  277 
8.  19130  PhD Jera Jeruc  Microbiology and immunology  Researcher  2009 - 2011  161 
9.  17949  Tadeja Klemenc    Technician  2011 
10.  11132  PhD Branko Krt  Veterinarian medicine  Researcher  2008  225 
11.  24296  PhD Darja Kušar  Veterinarian medicine  Researcher  2009 - 2011  177 
12.  16346  PhD Tadej Malovrh  Veterinarian medicine  Researcher  2008 - 2011  319 
13.  11879  PhD Jasna Mičunovič  Veterinarian medicine  Technician  2008 - 2011  84 
14.  11133  PhD Matjaž Ocepek  Veterinarian medicine  Principal Researcher  2008 - 2011  460 
15.  24612  PhD Mateja Pate  Veterinarian medicine  Researcher  2008  273 
16.  16247  PhD Tadeja Pintar  Cardiovascular system  Researcher  2008 - 2011  287 
17.  10909  PhD Alojz Pleskovič  Neurobiology  Researcher  2008 - 2011  197 
18.  01644  PhD Milan Pogačnik  Veterinarian medicine  Researcher  2008  624 
19.  01528  PhD Stanislav Repše  Oncology  Researcher  2008 - 2011  307 
20.  18884  PhD Tanja Švara  Veterinarian medicine  Researcher  2008 - 2011  211 
21.  07088  PhD Boris Vodopivec  Neurobiology  Researcher  2008  36 
Organisations (3)
no. Code Research organisation City Registration number No. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  73,209 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  44,132 
3.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  9,696 
Significance for science
Development and optimization of new DNA extraction procedures and development of new highly efficient DNA amplification using real time PCR represent an important contribution to the development of paratuberculosis diagnostics on international level as there is still no reliable method for diagnostics of paratuberculosis comercially available. Comparison of serum ELISA, milk ELISA, culture method and molecular tests showed markedly (up to 50-times) lower sensitivity of serological tests compared to culture and molecular methods used in herds with clinical paratuberculosis. In herds with latent paratuberculosis, milk and serum ELISA gave discrepant results and have most probably only 90% specificity. These findings are important on international level as up to date comparison results are contadictive and frequently based on out-of-date methods. The results of the study on CD patients indicate a link between the presence of Map in the intestines and blood and CD. However, to demonstrate the causative link further studies are needed. Detection of polymorphisms which determine genetic predisposition of CD patients in Slovenia represents an important piece of global knowledge on the etiology of CD.
Significance for the country
In the scope of this project it was demonstrated that large herds of dairy cattle are infected with Map to a large extent. This calls for immediate preparation of control measures on the state level as paratuberculosis may endanger the economy of infected herds which represent an important share of milk production in Slovenia. In heavily infected herds, the measures were implemented already during the project to partially limit the losses due to paratuberculosis and to preserve milk production in these herds. Improved diagnostics of paratuberculosis will contribute to easier and faster detection of infected animals/herds and to more efficient suppression of the disease. Efficient diagnostics (which is nowadays mostly unsatisfactory) is a prerequisite to motivate the cattle breeders for implementation of the control measures as these will bring satisfactory effects on a long term only. Knowledge on shedding of mycobacteria and their survival in the environment and in food will help us to detect critical points for spread of the infection and potential danger of the food for public health. On this basis, the measures for limiting the spread of disease and providing safer food may be proposed.
Most important scientific results Annual report 2008, 2009, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2008, 2009, final report, complete report on dLib.si
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