Projects / Programmes
Primerjalna genomika in genomska biodiverziteta (Slovene)
January 1, 2009
- December 31, 2014
| Code |
Science |
Field |
Subfield |
| 4.02.00 |
Biotechnical sciences |
Animal production |
|
| 4.06.00 |
Biotechnical sciences |
Biotechnology |
|
| 3.04.00 |
Medical sciences |
Oncology |
|
| 3.05.00 |
Medical sciences |
Human reproduction |
|
| Code |
Science |
Field |
| 4.04 |
Agricultural and Veterinary Sciences |
Agricultural biotechnology |
Researchers (44)
Organisations (2)
Abstract
Genomic revolution characterized significantly development of basic and applied biological sciences during the last decade. Application of modern methods in genetics, molecular and cell biology and immunology combined with high throughput genomic techniques opened a new horizon for acquisition of knowledge about structure and function of complex genomes. The programme is modular with an accent on the study of natural and breeding populations and comparative approach for study of genetic determination of traits related to health and production traits. The module dealing with the biology of lactation is focused on the regulation of lactoprotein expression in the mammary gland of different species in different physiological conditions. In addition to genes which play an important role in the regulation of milk composition and technological properties of milk is module focused on genes regulating development of the mammary gland and immune response during infections. Due to its cyclic character is mammary gland an ideal model for developmental studies including mammary gland involution. For the study of gene function we apply in vitro systems which enable analysis of gene function under controlled conditions and a wide range of experimental approaches. An important aspect of the module is study of post transcriptional processing of mRNA and modulation of gene expression by RNA interference. The cyclic development of the mammary gland enables study of the role of stem cells in mammary gland development and tumourigenesis. Detection of candidate genes and development of animal models is the focus of the module dealing with QTL mapping for traits related with energy metabolism and fat deposition. Identification of candidate loci is performed in different steps including QTL mapping, development of informative markers and selection of candidate genes according to their physiological role and genetic variation in the population. The effect of genetic variants of selected candidate genes is verified by association studies in selected populations, however, we are also developing transgenic mouse model for in vivo study of target genomic regions. In addition to factors affecting energy metabolism, the special focus of the programme is on biogenesis of mitochondria and interactions between nuclear and mitochondrial genome. The study of molecular basis of antigenic variation in avian mycoplasmas reveals molecular mechanisms which allow successful escape of the host immune system and survival of avian mycoplasmas in immunocompetent host. Study of immune response is an overriding topic of the programme connecting different modules of the programme in the search for novel solutions in the fight against infections. The module focused on population aspect of free living and bred populations enables survey of populations, establishment of relationships between populations and their history. In addition, the module elucidates the taxonomic position of rare and endangered species and contributes to appropriate management of those populations. Development of cytogenetic methods for diagnostic purposes in human medicine is methodologically connected with other modules and opens a comparative aspect into the medical research.
Significance for science
Program group is in many areas at the forefront of research. Areas where active contribute to the generation of new knowledge are lactation biology, stem cell characterization, the study of the molecular background of obesity, the development of animal models for the study of obesity, understanding the evolutionary development of Salmonids in Southeastern Europe, immunogenic determinants of avian and wider animal mycoplasmas, development of new diagnostic methods in human cytogenetics and reconstruction of the history of breeds of domestic animals. In the field of genomics research we are included in the larger consortia and there with their knowledge of the genetic background of complex traits we contribute to the generation of new knowledge.
Significance for the country
The importance of the program group for Slovenia is in the transfer of cutting-edge expertise in the local environment and in the application of knowledge in practice and transfer of methodological innovations for different end-users. Through the publication of our results we contribute also to strengthening the reputation of Slovenian science in the world. Our students who successfully pursue a scientific career abroad are our ambassadors and important contact points at research institutions abroad. The program group also specifically provides continuous progress in medical diagnostic procedures and constantly updates methods that are used for the management of genetic resources and to improve the genetic basis of domestic animals.
Audiovisual sources (1)
Most important scientific results
Annual report
2009,
2010,
2011,
2012,
2013,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2009,
2010,
2011,
2012,
2013,
final report,
complete report on dLib.si
