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Projects / Programmes source: ARIS

Primerjalna genomika in genomska biodiverziteta (Slovene)

Periods
Research activity

Code Science Field Subfield
4.02.00  Biotechnical sciences  Animal production   
4.06.00  Biotechnical sciences  Biotechnology   
3.04.00  Medical sciences  Oncology   
3.05.00  Medical sciences  Human reproduction   

Code Science Field
4.04  Agricultural and Veterinary Sciences  Agricultural biotechnology 
Evaluation (rules)
source: COBISS
Researchers (44)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  07914  PhD Dušan Benčina  Veterinarian medicine  Researcher  2009 - 2014  223 
2.  27545  PhD Rebeka Lucijana Berčič  Animal production  Researcher  2009 - 2012  112 
3.  33147  PhD Luka Bolha  Biochemistry and molecular biology  Junior researcher  2010 - 2014  26 
4.  23779  Nina Brumec    Technical associate  2009 - 2014 
5.  31912  PhD Nina Cirkvenčič  Pharmacy  Junior researcher  2009 - 2013 
6.  29430  PhD Ivanka Cizelj  Biotechnology  Researcher  2009 - 2014  51 
7.  31911  PhD Eva Čeh  Biotechnology  Junior researcher  2009 - 2013  38 
8.  35373  PhD Ida Djurdjevič  Animal production  Junior researcher  2012 - 2014  35 
9.  05098  PhD Peter Dovč  Biotechnology  Head  2009 - 2014  935 
10.  29431  PhD Daliborka Dušanić  Biotechnology  Researcher  2009 - 2013  42 
11.  20135  PhD Alenka Erjavec Škerget  Human reproduction  Researcher  2009 - 2014  150 
12.  33149  Irena Godnič  Biotechnology  Junior researcher  2010 - 2013  31 
13.  10412  PhD Simon Horvat  Biotechnical sciences  Researcher  2009 - 2014  561 
14.  18981  PhD Tatjana Kavar  Animal production  Researcher  2010 - 2014  75 
15.  29432  PhD Rok Keber  Biotechnology  Junior researcher  2009 - 2012  52 
16.  13343  PhD Nadja Kokalj Vokač  Oncology  Researcher  2009 - 2014  448 
17.  34335  PhD Saša Koprivec  Veterinarian medicine  Junior researcher  2011 - 2014  25 
18.  30811  PhD Danijela Krgović  Oncology  Junior researcher  2009 - 2014  79 
19.  16361  PhD Tanja Kunej  Animal production  Researcher  2009 - 2014  919 
20.  33997  Vesna Mrak    Technical associate  2012 - 2014  15 
21.  05008  PhD Mojca Narat  Biotechnology  Researcher  2009 - 2014  688 
22.  28505  PhD Jernej Ogorevc  Animal production  Researcher  2009 - 2014  137 
23.  24298  PhD Irena Oven  Animal production  Researcher  2009 - 2014  81 
24.  29433  PhD Anja Palandačić  Human reproduction  Junior researcher  2009 - 2011  42 
25.  27547  PhD Zala Prevoršek  Animal production  Researcher  2009 - 2012  42 
26.  34334  PhD Jasmina Puc  Biotechnology  Junior researcher  2011 - 2014  18 
27.  22445  PhD Andrej Razpet  Biotechnology  Researcher  2009 - 2012  64 
28.  34336  PhD Andrej Renčelj  Medical sciences  Junior researcher  2011 - 2014  22 
29.  24369  PhD Matjaž Simončič  Biotechnology  Researcher  2009  23 
30.  28506  PhD Urška Sivka  Biochemistry and molecular biology  Technical associate  2009 - 2014  19 
31.  11906  PhD Aleš Snoj  Animal production  Researcher  2009 - 2014  219 
32.  20200  PhD Špela Stangler Herodež  Oncology  Researcher  2009 - 2014  241 
33.  33151  PhD David Stanković  Biotechnology  Junior researcher  2010 - 2014  119 
34.  15658  PhD Simona Sušnik Bajec  Biochemistry and molecular biology  Researcher  2009 - 2014  194 
35.  18853  Ljubica Šalgaj    Technical associate  2009 - 2014 
36.  17513  Vida Štuhec    Technical associate  2009  10 
37.  18851  Simona Varžič    Technical associate  2009 - 2014 
38.  13152  PhD Damijan Vokač  Cardiovascular system  Researcher  2010 - 2014  164 
39.  15747  Andreja Zagorac  Human reproduction  Technical associate  2009 - 2014  154 
40.  18852  Suzana Zagorc-Lapuh    Technical associate  2009 - 2014 
41.  18205  PhD Boris Zagradišnik  Oncology  Researcher  2009 - 2014  259 
42.  32581  PhD Minja Zorc  Computer science and informatics  Researcher  2014  182 
43.  37602  Jelena Zurc    Technical associate  2014 
44.  28404  PhD Katja Žerjavič  Oncology  Junior researcher  2009 - 2011  46 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  22,866 
2.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  66,847 
Abstract
Genomic revolution characterized significantly development of basic and applied biological sciences during the last decade. Application of modern methods in genetics, molecular and cell biology and immunology combined with high throughput genomic techniques opened a new horizon for acquisition of knowledge about structure and function of complex genomes. The programme is modular with an accent on the study of natural and breeding populations and comparative approach for study of genetic determination of traits related to health and production traits. The module dealing with the biology of lactation is focused on the regulation of lactoprotein expression in the mammary gland of different species in different physiological conditions. In addition to genes which play an important role in the regulation of milk composition and technological properties of milk is module focused on genes regulating development of the mammary gland and immune response during infections. Due to its cyclic character is mammary gland an ideal model for developmental studies including mammary gland involution. For the study of gene function we apply in vitro systems which enable analysis of gene function under controlled conditions and a wide range of experimental approaches. An important aspect of the module is study of post transcriptional processing of mRNA and modulation of gene expression by RNA interference. The cyclic development of the mammary gland enables study of the role of stem cells in mammary gland development and tumourigenesis. Detection of candidate genes and development of animal models is the focus of the module dealing with QTL mapping for traits related with energy metabolism and fat deposition. Identification of candidate loci is performed in different steps including QTL mapping, development of informative markers and selection of candidate genes according to their physiological role and genetic variation in the population. The effect of genetic variants of selected candidate genes is verified by association studies in selected populations, however, we are also developing transgenic mouse model for in vivo study of target genomic regions. In addition to factors affecting energy metabolism, the special focus of the programme is on biogenesis of mitochondria and interactions between nuclear and mitochondrial genome. The study of molecular basis of antigenic variation in avian mycoplasmas reveals molecular mechanisms which allow successful escape of the host immune system and survival of avian mycoplasmas in immunocompetent host. Study of immune response is an overriding topic of the programme connecting different modules of the programme in the search for novel solutions in the fight against infections. The module focused on population aspect of free living and bred populations enables survey of populations, establishment of relationships between populations and their history. In addition, the module elucidates the taxonomic position of rare and endangered species and contributes to appropriate management of those populations. Development of cytogenetic methods for diagnostic purposes in human medicine is methodologically connected with other modules and opens a comparative aspect into the medical research.
Significance for science
Program group is in many areas at the forefront of research. Areas where active contribute to the generation of new knowledge are lactation biology, stem cell characterization, the study of the molecular background of obesity, the development of animal models for the study of obesity, understanding the evolutionary development of Salmonids in Southeastern Europe, immunogenic determinants of avian and wider animal mycoplasmas, development of new diagnostic methods in human cytogenetics and reconstruction of the history of breeds of domestic animals. In the field of genomics research we are included in the larger consortia and there with their knowledge of the genetic background of complex traits we contribute to the generation of new knowledge.
Significance for the country
The importance of the program group for Slovenia is in the transfer of cutting-edge expertise in the local environment and in the application of knowledge in practice and transfer of methodological innovations for different end-users. Through the publication of our results we contribute also to strengthening the reputation of Slovenian science in the world. Our students who successfully pursue a scientific career abroad are our ambassadors and important contact points at research institutions abroad. The program group also specifically provides continuous progress in medical diagnostic procedures and constantly updates methods that are used for the management of genetic resources and to improve the genetic basis of domestic animals.
Audiovisual sources (1)
no. Title (with video link) Event Source
1. Primerjalna genomika in genomska biodiverziteta (Slovene)  Promotional video of research programme on Videolectures  Research programme video presentation 
Most important scientific results Annual report 2009, 2010, 2011, 2012, 2013, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, 2012, 2013, final report, complete report on dLib.si
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