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Projects / Programmes source: ARIS

Izolacija velikih biomolekul in nanodelcev (Slovene)

Periods
January 1, 2009 - December 31, 2012
Research activity

Code Science Field Subfield
4.06.00  Biotechnical sciences  Biotechnology   
2.04.00  Engineering sciences and technologies  Materials science and technology   

Code Science Field
2.09  Engineering and Technology  Industrial biotechnology 
Evaluation (rules)
source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  12667  PhD Miloš Barut  Chemistry  Researcher  2009 - 2012  206 
2.  24077  PhD Peter Brne  Chemistry  Junior researcher in economics  2009 - 2012  28 
3.  17278  MSc Janez Jančar  Chemical engineering  Technical associate  2009 - 2012  61 
4.  24078  Sandra Kontrec    Technical associate  2009 - 2012 
5.  24377  PhD Nika Lendero Krajnc  Chemistry  Researcher  2009 - 2012  96 
6.  20412  PhD Mojca Merhar  Pharmacy  Researcher  2009 - 2011  33 
7.  16327  PhD Matjaž Peterka  Biotechnology  Researcher  2009 - 2012  218 
8.  12728  PhD Aleš Podgornik  Chemical engineering  Head  2009 - 2012  709 
9.  00779  PhD Aleš Štrancar  Chemical engineering  Researcher  2009 - 2012  479 
10.  27846  PhD Lidija Urbas  Pharmacy  Junior researcher in economics  2009 - 2012  49 
11.  23594  PhD Jana Vidič  Materials science and technology  Researcher  2009 - 2012  65 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  1655  Sartorius BIA Separations L.t.d., Separations technology company  Ajdovščina  1319612  1,189 
Significance for science
Detailed characterization of supports provided insight into adsorption-desorption processes of macromolecules, enabling development of predefined monolith microscopic structure and design of appropriate housing. Better understanding of adsorption phenomena also enabled prediction of specificity for certain chemical moieties as well as strength of interaction and consequently isolation yield. As an outcome, monolith bearing different chemical functionalities in predefined order on a single skeleton was prepared and characterized with proteins, representing novel approach in purification. Results obtained with test samples were further investigated with different important molecules like plasmid DNA and bacteriophages, later due to their geometrically defined structure and safety. Based on a pressure drop measurement data we were able to predict bacteriophage orientation after adsorption – another novel scientific outcome of this work.
Significance for the country
Program contributed for development of Slovenia in two fields: one is recognition of Slovenia as hi-tech country while the second is generation of new job positions. CIM monolithic supports are today already well established matrix in the field of chromatography recognized worldwide, as a commercially product but also as an scientific topic, always related to Slovenia. On the other hand, company BIA Separations, where this program was performed, generated in last 3 years over 20 new working positions, mainly for highly educated employees.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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