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Projects / Programmes source: ARIS

Keratini in znižanje celične adhezije: posledice za krhkost epitelija pri kroničnem vnetju črevesja (Slovene)

Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  16104  PhD Apolonija Bedina Zavec  Biotechnology  Researcher  2009  154 
2.  20347  PhD Klementina Fon Tacer  Metabolic and hormonal disorders  Researcher  2010  127 
3.  06135  PhD Radovan Komel  Biochemistry and molecular biology  Researcher  2009  1,054 
4.  21507  PhD Branka Korošec  Systems and cybernetics  Researcher  2009  61 
5.  14305  PhD Mirjana Liović  Metabolic and hormonal disorders  Head  2009 - 2012  148 
6.  22580  PhD Špela Peternel  Biochemistry and molecular biology  Researcher  2010 - 2011  42 
7.  22459  PhD Tadeja Režen  Neurobiology  Researcher  2012  246 
8.  27742  PhD Alja Videtič Paska  Medical sciences  Researcher  2012  222 
9.  33509  Tina Zupančič  Biotechnology  Technical associate  2011 - 2012  25 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,264 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,729 
Significance for science
We have provided evidence in favour of two hypotheses. First, keratin gene mutations not cause a down-regulation in cell junction proteins, but also in their distribution, and this does reflect also on the function of simple epithelial keratins K8/K18. We have demonstrated for the first time that K8/K18 mutations do affect paracellular transport and can induce an increase in ”cell leakage” through tight junction destabilization. Second, we have demonstrated that severe keratin mutants have another joint characteristic, which is a lower sensibility to apoptosis inducing ligands, such as TNF and TRAIL. These data demonstrate that cells carrying keratin gene mutations suffer from a number of physiological changes, which on one hand are compensational mechanisms that function to promote cell survival, proliferation and wound healing (in terms of tissue fragiltiy disorders), while on the other are a step closer towards epithelial-mesenchymal transformation and tumor genesis. These findings are original and of great importance for the development of basic science in this field of research.
Significance for the country
through our research and by presenting our work at international meetings in the EU and USA we have also advertised Slovenia and Slovenian science. We have many international collaborators and we are part of a privileged number of top labs in the world in this field. Further development is possible, but it demands much higher investments into research and development than there are at the moment.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Final report, complete report on dLib.si
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