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Projects / Programmes source: ARIS

Izrazanje in funkcionalna analiza nekodirajocih RNA pri parkinsonovi bolezni (Slovene)

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Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
3.05  Medical and Health Sciences  Other medical sciences 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (13)
no. Code Name and surname Research area Role Period No. of publications
1.  23598  PhD Tomaž Bratkovič  Pharmacy  Researcher  2009 - 2012  235 
2.  18324  PhD Gordana Glavan  Neurobiology  Researcher  2009 - 2012  144 
3.  12688  PhD Kristina Gruden  Biotechnology  Researcher  2011  985 
4.  25483  PhD Nejc Jelen  Biochemistry and molecular biology  Researcher  2009  74 
5.  04648  PhD Janko Kos  Biotechnical sciences  Researcher  2009  1,159 
6.  25494  PhD Nataša Obermajer  Biotechnology  Researcher  2009 - 2010  196 
7.  26507  PhD Jure Pohleven  Biochemistry and molecular biology  Researcher  2009 - 2012  75 
8.  34292  Gregor Ramovš    Technical associate  2012  0 
9.  22459  PhD Tadeja Režen  Neurobiology  Researcher  2010 - 2012  235 
10.  15813  PhD Boris Rogelj  Neurobiology  Head  2009 - 2012  412 
11.  07849  PhD Borut Štrukelj  Biochemistry and molecular biology  Researcher  2009 - 2012  1,125 
12.  08289  PhD Marko Živin  Neurobiology  Researcher  2009 - 2012  233 
13.  17285  Darja Žunič Kotar    Technical associate  2010 - 2012  2 
Organisations (3)
no. Code Research organisation City Registration number No. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,724 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,238 
3.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,172 
Significance for science
The main aim of this project was to investigate the function of non-coding micro RNAs in Parkinson's disease. In the last decade there has been an increasing awareness of the importance of micro RNAs and RNA metabolism for the biological processes. With the advent of new techniques and technologies we are able to focus on the role of RNA in biological processes and disease. Beside the numerous high impact scientific publications, 2006 Nobel Prize in Physiology and Medicine was awarded for the discovery of RNA interference. Beside providing better understanding of the miRNA related molecular mechanisms in Parkinson's disease, the differentially expressed miRNAs that we elucidated, may define new targets for therapeutic intervention possibly using the rapidly developing RNA-based therapies.
Significance for the country
There is increasing awareness of the importance of non-coding RNAs in the regulation of biological and pathological processes. The proposed project is a basic medical sciences project which aims to investigate the molecular mechanism of Parkinson's disease at the level of non-coding RNAs. There are about 4000 Parkinson's disease patients in Slovenia and after Alzheimer's disease it is the second most common neurodegenerative disease associated with old age. This project will enable some cutting-edge research to expand molecular neurosciences research in Slovenia. Furthermore, the function of non-coding RNAs is being researched in other biomedical fields and this project would bring some of the know-how to Slovenia, thus enabling the expansion of the technology to research Alzheimer's disease. Additionally, we have develloped the collaboration between the four applicant institutions in Slovenia, with the MRC Center for Neurodegeneration Research from King's College London, UK, and MRC Laboratory of Molecular Biology from Cambridge, UK.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, final report, complete report on dLib.si
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