Projects / Programmes
Protivirusni proteini APOBEC3 in njihova vloga pri obrambi proti retroelementom (Slovene)
Code |
Science |
Field |
Subfield |
7.00.00 |
Interdisciplinary research |
|
|
Code |
Science |
Field |
3.01 |
Medical and Health Sciences |
Basic medicine |
Researchers (5)
no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
1. |
26491 |
PhD Maruška Budič |
Biochemistry and molecular biology |
Researcher |
2011 - 2012 |
24 |
2. |
07673 |
PhD Dušan Kordiš |
Biochemistry and molecular biology |
Researcher |
2009 - 2012 |
215 |
3. |
00412 |
PhD Igor Križaj |
Biochemistry and molecular biology |
Researcher |
2009 - 2012 |
725 |
4. |
19649 |
PhD Marija Nika Lovšin |
Microbiology and immunology |
Head |
2009 - 2012 |
124 |
5. |
15640 |
PhD Vera Župunski |
Biochemistry and molecular biology |
Researcher |
2009 - 2012 |
185 |
Organisations (2)
Significance for science
Since their discovery in 2002, APOBEC3 proteins have been a “hot topic” in the field of HIV1
research. Being a promising target for antiviral treatment, they have been extensively
studied. Yet, the mechanisms of their action are still not well understood. The proposed
project uses stateoftheart methods to examine APOBEC3 proteins, and it is on the cutting
edge of viral research. Our findings are not interesting only to the scientific community, but
will significantly contribute to our understanding of retroviruses and may prompt
development of new antiviral therapies. In addition, we will develop novel methods for
protein and RNA analyses in the cell. Our "CLIP" analysis of APOBEC3 targets may open a
new field of APOBEC3 research. This advancement will be beneficial for the quality of
biomedical and biological research in Slovenia.
Significance for the country
The long term goal of the proposed study is the development of antiviral therapies. Due to
the toxicity of currently used therapies and emergence of drug resistant HIV1
strains the
drug development has changed its focus from inhibiting viral enzymes to defining specific
interactions between virus and hostcell
with a potential to drug intervention. HIV1
depends heavily on hostcell
factors that enable virus to enter the cell, multiply and cause
an infection. APOBEC3 proteins play a major role in vertebrate innate immunity, which
actively blocks exogenous and endogenous retroviruses. Understanding the mechanism of
their antiretroviral activity, a subject of this proposal, is therefore crucial for the
development of new therapies. Pharmacologically interesting results, such as novel
APOBEC3 RNA targets, will enable further strengthening of our collaboration with the
pharmaceutical industry and improvement of the relationship between the scientific
community and the economy in Slovenia.
Most important scientific results
Annual report
2009,
2010,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2009,
2010,
2011,
final report,
complete report on dLib.si