Projects / Programmes source: ARIS

Protivirusni proteini APOBEC3 in njihova vloga pri obrambi proti retroelementom (Slovene)

Research activity

Code Science Field Subfield
7.00.00  Interdisciplinary research     

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
Evaluation (rules)
source: COBISS
Researchers (5)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  26491  PhD Maruška Budič  Biochemistry and molecular biology  Researcher  2011 - 2012  24 
2.  07673  PhD Dušan Kordiš  Biochemistry and molecular biology  Researcher  2009 - 2012  215 
3.  00412  PhD Igor Križaj  Biochemistry and molecular biology  Researcher  2009 - 2012  727 
4.  19649  PhD Marija Nika Lovšin  Microbiology and immunology  Head  2009 - 2012  125 
5.  15640  PhD Vera Župunski  Biochemistry and molecular biology  Researcher  2009 - 2012  185 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,168 
2.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,987 
Significance for science
Since their discovery in 2002, APOBEC3 proteins have been a “hot topic” in the field of HIV1 research. Being a promising target for antiviral treatment, they have been extensively studied. Yet, the mechanisms of their action are still not well understood. The proposed project uses stateoftheart methods to examine APOBEC3 proteins, and it is on the cutting edge of viral research. Our findings are not interesting only to the scientific community, but will significantly contribute to our understanding of retroviruses and may prompt development of new antiviral therapies. In addition, we will develop novel methods for protein and RNA analyses in the cell. Our "CLIP" analysis of APOBEC3 targets may open a new field of APOBEC3 research. This advancement will be beneficial for the quality of biomedical and biological research in Slovenia.
Significance for the country
The long term goal of the proposed study is the development of antiviral therapies. Due to the toxicity of currently used therapies and emergence of drug resistant HIV1 strains the drug development has changed its focus from inhibiting viral enzymes to defining specific interactions between virus and hostcell with a potential to drug intervention. HIV1 depends heavily on hostcell factors that enable virus to enter the cell, multiply and cause an infection. APOBEC3 proteins play a major role in vertebrate innate immunity, which actively blocks exogenous and endogenous retroviruses. Understanding the mechanism of their antiretroviral activity, a subject of this proposal, is therefore crucial for the development of new therapies. Pharmacologically interesting results, such as novel APOBEC3 RNA targets, will enable further strengthening of our collaboration with the pharmaceutical industry and improvement of the relationship between the scientific community and the economy in Slovenia.
Most important scientific results Annual report 2009, 2010, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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