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Projects / Programmes source: ARIS

Vnos zdravilnih učinkovin v kožo in preko kože z elektroporacijo, ionoforezo in radiofrekvenčnim segrevanjem (Slovene)

Research activity

Code Science Field Subfield
2.06.07  Engineering sciences and technologies  Systems and cybernetics  Biomedical technics 

Code Science Field
2.06  Engineering and Technology  Medical engineering  
Evaluation (rules)
source: COBISS
Researchers (16)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  19722  PhD Tina Batista Napotnik  Systems and cybernetics  Researcher  2009  59 
2.  27964  PhD Selma Čorović  Electric devices  Researcher  2009 - 2011  121 
3.  02204  PhD Karel Flisar  Systems and cybernetics  Researcher  2010 - 2012  72 
4.  31281  Ivanka Jelenc  Systems and cybernetics  Researcher  2009 - 2010 
5.  08808  Jože Jelenc  Systems and cybernetics  Researcher  2009 - 2012  62 
6.  31771  Katja Knific  Economics  Researcher  2011 - 2012 
7.  15675  PhD Tadej Kotnik  Systems and cybernetics  Researcher  2010 - 2012  204 
8.  34298  PhD Samo Mahnič-Kalamiza  Systems and cybernetics  Researcher  2011 - 2012  74 
9.  10268  PhD Damijan Miklavčič  Systems and cybernetics  Head  2009 - 2012  1,492 
10.  20822  PhD Nataša Pavšelj  Systems and cybernetics  Researcher  2009 - 2012  82 
11.  23755  Nikola Radaković  Systems and cybernetics  Researcher  2009 - 2012  14 
12.  25421  PhD Matej Reberšek  Systems and cybernetics  Researcher  2011 - 2012  163 
13.  19435  Uroš Tacar    Technical associate  2009 - 2012 
14.  28459  PhD Marko Ušaj  Biotechnology  Researcher  2011 - 2012  70 
15.  09178  PhD Janko Žmitek  Pharmacy  Researcher  2011 - 2012  297 
16.  24278  PhD Katja Žmitek  Public health (occupational safety)  Researcher  2011 - 2012  167 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  1538  University of Ljubljana, Faculty of Electrical Engineering  Ljubljana  1626965  27,596 
2.  2885  VIST - Faculty of Applied Sciences  Ljubljana  2288591  781 
3.  6582  Iskra Medical, R & D Medical and Cosmetics Devices  Ljubljana  5516641  97 
Significance for science
Recent advances in pharmacy and biotechnology have yielded a number of drugs exerting good therapeutic effect and getting approvals by regulatory agencies to be used for medical use. However, one of the biggest challenges in the area of biomedical engineering is finding the right ways of delivering molecules to targeted sites inside the human body. Apart from invasive hypodermic needle (intramuscular or intravenous delivery route), most common non-invasive delivery routes include peroral, transmucosal, inhalation and transdermal routes. Skin serves as a protective barrier, also playing an important role in sensory perception, immunologic surveillance, thermoregulation, and control of insensible fluid loss. Due to its size and accessibility, skin is an attractive target tissue for a variety of applications. Current trends show increased interest in the field of intra- and transdermal drug delivery. Namely, this delivery route represents noninvasive alternatives to most widely used invasive hypodermic needle and a way to avoid first pass metabolism that can present a problem in oral dosage forms. The delivery of drugs through skin is a desirable alternative to other delivery routes, however, its biggest obstacle is the main function of the skin: to prevent unwanted substances from entering the body. The problem of successful transdermal drug delivery was approached from different angles, comprising theoretical aspects, hardware solutions and in vitro testing. In this way, we substantially added to further advancement and understanding in the field of transdermal drug delivery, with the aim of establishing this delivery route as a successful, noninvasive alternative. The work programmed comprise all crucial aspects of development of medical devices for transdermal drug delivery based on the state-of-the-art science: The theoretical support in the form of mathematical models, hardware solutions according to identified needs and constraints, and testing of both in a modern experimental environment. With this approach, we established a knowledge-based, complete technological platform for the development of new, state-of-the-art medical devices, corresponding electrodes and applicators for electrically-mediated transdermal drug delivery.
Significance for the country
Our studies, pertaining to the area of health and life sciences were and still are consistent with the guidelines of the Ministry of Higher Education, Science and Technology. One of the results of the project is a clinical device with the appending applicators and protocols for intra- and transdermal drug delivery which will be manufactured and marketed by the SME involved in the research, Iskra Medical, the co-financer of the project. The efforts of the company’s management for increasing the added value of their products were completed by the development of devices and protocols supported by scientific theoretical and experimental results. Apart from the financial return for the collaborating SME, scientific achievements did put Slovenian science in the leading front of the research in the field of electrically-mediated transdermal drug delivery. The continuation of active participation of Slovenian researchers in this research area represents an important recognition of Slovenian science that will put us side by side with leading scientists in the field of transdermal drug delivery. Further, the accumulation of knowledge and technological solutions gives an opportunity for Slovenian SMEs to be involved in the design and manufacture of this new technology. In addition, by establishing an experimental environment for in vitro testing and by developing new, state-of-the-art medical devices, corresponding electrodes and applicators for electrically-mediated transdermal drug delivery, we provided a long-term support for research work in this field, extending beyond the time-frame of this project. As the research was performed at the Faculty of Electrical Engineering of the University of Ljubljana, the results and findings are readily incorporated in educational process. Newly established experimental laboratory is available to the students at the University of Ljubljana and it represents a welcome addition to the educational process (Skin Electroporation as new lab work at the study of Biomedical engineering at University of Ljubljana). Also, graduate and postgraduate students will get an opportunity to take part in the research in the framework of their theses. New knowledge about enhanced transdermal drug delivery, gained during this project also contributed to the quality of international postgraduate school program, named Electroporation in biology, biotechnology and medicine. Added value to the program has also represented Skin electroporation as a new lab work for participants. Also, we would like to emphasize that the development and future manufacture of medical devices for transdermal drug delivery by electroporation was taken place in Iskra Medical’s remote unit in Gorenjska, which is one of the economically less developed regions of Slovenia.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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