Projects / Programmes
Rastlinski polifenoli: možnosti in omejitve uporabe v prehrani in medicini (Slovene)
| Code |
Science |
Field |
Subfield |
| 4.03.07 |
Biotechnical sciences |
Plant production |
Technology of vegetal origin food |
Researchers (1)
| no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
| 1. |
21399 |
PhD Andreja Vanzo |
Plant production |
Head |
2009 - 2011 |
249 |
Organisations (1)
Significance for science
The research topics and aims of this project are interdisciplinary (including Plant production, Biochemistry, Molecular Biology, Biotechnical Sciences, Nutrition, Human Physiology) and shall therefore be implemented into international research team. The principal investigator already firmly cooperates with researchers from Italy (University of Trieste, Istituto Agrario San Michele-IASMA Research and Innovation Center), researchers from Argentina (Faculty of Pharmacy, Rosario) and researchers from South Africa (University of Stellenbosch). Such cooperation is important for knowledge transfer. Young researchers are firmly included in the project and in a research group in Slovenia as well abroad.
It has been less than a decade the world 'metabolome' was first used reffereing to all low molecular mass compounds synthesized by a living cell or organism (1). As a consequence, metabolomics emerged a new field in the biological science, achieving tremendous development and popularity in the last couple of years. Metabolomics is a consequence of genomics and proteomics. Using non-target analyses of primary and secondary metabolites, which are formed as a consequence of nutrition of plant polyphenols, the target analyses results were fairly improved. The potential biomarkers which shall enable us to understand biological effects of polyphenols in the organism were investigated (2,3,4).
References:
(1) VILLAS-BOAS, Silas G., ROESSNER, Ute, HANSEN, Michael A.E., SMEDSGAARD, Jorn, NIELSEN, Jens. Metabolome Analysis. An Introduction. Eds: Desiderio D.M., Nibbering. N.M.M. et al. John Wiley & Sons, Inc., Hoboken, New Yersey, 2007, 311 str.
(2) VRHOVŠEK, Urška, VANZO, Andreja, TRAMER, Federica, FRANCESCHI, Pietro, MATTIVI, Fulvio, PASSAMONTI, Sabina. Target versus non-target analytical approach for describing metabolism of anthocyanins in rat. V: Metabolomics Society`s 5th Annual International Conference, Aug 30 - Sept 2, 2009, Edmonton, Canada : final program. Edmonton: [s.n.], 2009, str. 183-184.
(3) VANZO, Andreja, VRHOVŠEK, Urška, FRANCESCHI, Pietro, TRAMER, Federica, PASSAMONTI, Sabina, MATTIVI, Fulvio. Target versus non-target analytical approach for describing the metabolism of anthocyanins in rat. V: NuGOweek 2009. [S.l.]: European Nutrigenomics Organisation, [2009?], str. 123.
(4) VANZO, Andreja GASPEROTTI Mattia, SCHOLZ Matthias, TRAMER Federica, PASSAMONTI Sabina, VRHOVŠEK Urška MATTIVI Fulvio. Metabonomic investigation of rat tissues following intravenous administration of cyanidin 3-glucoside at a physiologically relevant dose. Submitted to Metabolomics.
Significance for the country
Investigating of polyphenol content in food and beverages produced in Slovenia is necessary. Beside variety, environmental factors are these who greatly impact the concentration and profile of polyphenols in fruit. Therefore, polyphenols content obtained in other countries can not be directly compared to Slovenia (even for the same variety). The investigation of polyphenol content impact the crop production in developed countries (lower crop-load, importance of local varieties, selection of resistant varieties etc.). The market value of some crops might increase, as a consequence of scientific evidence that they contain higher values of bioactive compounds (http://www.iasma.it/UploadDocs/2651_Interberry_NL__2_1.pdf).
The knowledge about biological effects of polyphenols in the organism is a tool to evaluate the nutritional value of specific polyphenols-rich food. Thus appropriate investigation of bioefficacy and pharmacokinetics of polyphenols might have an impact on both, health and agricultural policy.
Results upon research on bioactivity of polyphenols might help elaborating evidence-based dietary guidelines to improve the health status of the population. On a population scale, relatively modest changes, including adopting correct diets using high nutritional value food, will affect several of the risk factors associated with occurrence of chronical diseases, which might result in favorable changes in population health (2). In Finland, annual coronary heart disease mortality was reduced by a dramatic 73% over 25 years as a result of the North Karelia project encouraging a healthier diet (3).
References:
(2) (http://www.iasma.it/UploadDocs/2651_Interberry_NL__2_1.pdf).
(2) WHO, World Health Report. 2002.
(3) Pietinen, P., Lahti-Koski, M., Vartiainen, E., Puska, P., Nutrition and cardiovascular disease in Finland since the early 1970s: a success story. J Nutr Health Aging 2001, 5, 150-154.
Most important scientific results
Annual report
2009,
2010,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2009,
2010,
final report,
complete report on dLib.si
