Projects / Programmes
Intraoperative monitoring of the optic nerve function during neurosurgery using photopletysmography - a new application for intraoperative vision preservation
Code |
Science |
Field |
Subfield |
3.03.00 |
Medical sciences |
Neurobiology |
|
Code |
Science |
Field |
B640 |
Biomedical sciences |
Neurology, neuropsychology, neurophysiology |
Code |
Science |
Field |
3.02 |
Medical and Health Sciences |
Clinical medicine |
Intraoperative monitoring, optic nerve, photopletysmography, vision preservation, iatrogenic injury, neurosurgery
Researchers (14)
no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
1. |
11682 |
MSc Uroš Aljančič |
Electronic components and technologies |
Researcher |
2011 - 2014 |
206 |
2. |
01926 |
PhD Slavko Amon |
Electronic components and technologies |
Researcher |
2011 - 2014 |
473 |
3. |
24578 |
PhD Saba Battelino |
Neurobiology |
Researcher |
2011 - 2014 |
587 |
4. |
25617 |
PhD Mitja Benedičič |
Neurobiology |
Researcher |
2011 - 2014 |
105 |
5. |
10511 |
PhD Roman Bošnjak |
Neurobiology |
Head |
2011 - 2014 |
415 |
6. |
04409 |
PhD Jelka Brecelj |
Neurobiology |
Researcher |
2011 - 2014 |
347 |
7. |
17691 |
Romana Kren |
|
Technical associate |
2011 - 2014 |
0 |
8. |
20186 |
PhD Matej Možek |
Electronic components and technologies |
Researcher |
2011 - 2014 |
270 |
9. |
30683 |
PhD Borut Pečar |
Electronic components and technologies |
Junior researcher |
2011 - 2013 |
118 |
10. |
05075 |
PhD Drago Resnik |
Electronic components and technologies |
Researcher |
2011 - 2014 |
261 |
11. |
25616 |
PhD Maja Šuštar Habjan |
Neurobiology |
Researcher |
2011 - 2014 |
117 |
12. |
33904 |
Alenka Vittori |
Neurobiology |
Researcher |
2011 - 2014 |
33 |
13. |
04383 |
PhD Danilo Vrtačnik |
Electronic components and technologies |
Researcher |
2011 - 2014 |
309 |
14. |
33899 |
Nina Vujasinović |
Neurobiology |
Researcher |
2011 - 2014 |
0 |
Organisations (2)
Abstract
Additional (iatrogenic) injury to the optic nerve can follow indirect or direct surgical manipulations during tumor removal of central skull base and around optic nerves in up to 10-20 % of patients.
Microsurgical techniques enable preservance of the nerve continuity, but do not guarantee the conduction function preservance of the optic nerve, which depends critically on adequate perfusion.
This project proposes a new intraoperative application of photopletysmography (PPG) of the optic nerve to monitor microcirculation of the optic nerve by detecting and evaluating the pulse wave which will be compared to flash visual evoked potentitals.
Significance for science
The first realization of photoplethysmography applied to the optic nerve is a novelty in the concept of intraoperative neuromonitoring – it introduces a pulse wave instead of low amplitude variable electrical signals, which need time consuming averaging. The pulse wave responds directly and immediately to the manipulation with the tissue and is related to microcirculation in the tissue and may prevent iatrogenic injury better than electrophysiology. Microcirculation influences perfusion and thus metabolic processes which support conduction of electrical impulses along the nerve. This concept of non-invasive intraoperative monitoring of an organ function is also a technological challenge, which evokes new technological knowledge, materials and data processing. This concept of metabolic monitoring may have significant impact in the other fields of medicine, where vitality of the organ is jeopardized during medical procedures or surgery, especially in combination of photoplethysmography with pulse oximetry.
Significance for the country
Introducing a new original method of monitoring of the optic nerve function during demanding neurosurgery of the central skull base, the research organization University Medical Centre Ljubljana, as a tertiary institution, upgrades and improves its results in the field of perioperative vision preservation. This gives society a significant savings from preserving work ability and decreasing handicap of surgical patients. The collaborating partner, research group at the LMSE, UL-FE Ljubljana, adds technological solutions and realization of a new type of sensor, which is potentially a commercial product – a new measurement system. Novel basic medical, clinical and technological knowledge will be part of education programs, student exchange, surgical residency programs, new research work and cooperation with Slovenian researchers will be initiated.
Most important scientific results
Annual report
2011,
2012,
2013,
final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Annual report
2011,
2012,
2013,
final report,
complete report on dLib.si