Projects / Programmes source: ARIS

Intraoperative monitoring of the optic nerve function during neurosurgery using photopletysmography - a new application for intraoperative vision preservation

Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Intraoperative monitoring, optic nerve, photopletysmography, vision preservation, iatrogenic injury, neurosurgery
Evaluation (rules)
source: COBISS
Researchers (14)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  11682  MSc Uroš Aljančič  Electronic components and technologies  Researcher  2011 - 2014  206 
2.  01926  PhD Slavko Amon  Electronic components and technologies  Researcher  2011 - 2014  473 
3.  24578  PhD Saba Battelino  Neurobiology  Researcher  2011 - 2014  587 
4.  25617  PhD Mitja Benedičič  Neurobiology  Researcher  2011 - 2014  105 
5.  10511  PhD Roman Bošnjak  Neurobiology  Head  2011 - 2014  414 
6.  04409  PhD Jelka Brecelj  Neurobiology  Researcher  2011 - 2014  346 
7.  17691  Romana Kren    Technical associate  2011 - 2014 
8.  20186  PhD Matej Možek  Electronic components and technologies  Researcher  2011 - 2014  270 
9.  30683  PhD Borut Pečar  Electronic components and technologies  Junior researcher  2011 - 2013  118 
10.  05075  PhD Drago Resnik  Electronic components and technologies  Researcher  2011 - 2014  261 
11.  25616  PhD Maja Šuštar Habjan  Neurobiology  Researcher  2011 - 2014  116 
12.  33904  Alenka Vittori  Neurobiology  Researcher  2011 - 2014  33 
13.  04383  PhD Danilo Vrtačnik  Electronic components and technologies  Researcher  2011 - 2014  309 
14.  33899  Nina Vujasinović  Neurobiology  Researcher  2011 - 2014 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,699 
2.  1538  University of Ljubljana, Faculty of Electrical Engineering  Ljubljana  1626965  27,611 
Additional (iatrogenic) injury to the optic nerve can follow indirect or direct surgical manipulations during tumor removal of central skull base and around optic nerves in up to 10-20 % of patients. Microsurgical techniques enable preservance of the nerve continuity, but do not guarantee the conduction function preservance of the optic nerve, which depends critically on adequate perfusion. This project proposes a new intraoperative application of photopletysmography (PPG) of the optic nerve to monitor microcirculation of the optic nerve by detecting and evaluating the pulse wave which will be compared to flash visual evoked potentitals.
Significance for science
The first realization of photoplethysmography applied to the optic nerve is a novelty in the concept of intraoperative neuromonitoring – it introduces a pulse wave instead of low amplitude variable electrical signals, which need time consuming averaging. The pulse wave responds directly and immediately to the manipulation with the tissue and is related to microcirculation in the tissue and may prevent iatrogenic injury better than electrophysiology. Microcirculation influences perfusion and thus metabolic processes which support conduction of electrical impulses along the nerve. This concept of non-invasive intraoperative monitoring of an organ function is also a technological challenge, which evokes new technological knowledge, materials and data processing. This concept of metabolic monitoring may have significant impact in the other fields of medicine, where vitality of the organ is jeopardized during medical procedures or surgery, especially in combination of photoplethysmography with pulse oximetry.
Significance for the country
Introducing a new original method of monitoring of the optic nerve function during demanding neurosurgery of the central skull base, the research organization University Medical Centre Ljubljana, as a tertiary institution, upgrades and improves its results in the field of perioperative vision preservation. This gives society a significant savings from preserving work ability and decreasing handicap of surgical patients. The collaborating partner, research group at the LMSE, UL-FE Ljubljana, adds technological solutions and realization of a new type of sensor, which is potentially a commercial product – a new measurement system. Novel basic medical, clinical and technological knowledge will be part of education programs, student exchange, surgical residency programs, new research work and cooperation with Slovenian researchers will be initiated.
Most important scientific results Annual report 2011, 2012, 2013, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2011, 2012, 2013, final report, complete report on dLib.si
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