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Projects / Programmes source: ARIS

RENAL DISEASES AND RENAL REPLACEMENT THERAPY

Periods
Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   
3.07.00  Medical sciences  Metabolic and hormonal disorders   

Code Science Field
B530  Biomedical sciences  Cardiovascular system 

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Evaluation (rules)
source: COBISS
Researchers (17)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  21624  PhD Miha Arnol  Cardiovascular system  Researcher  2013 - 2016  465 
2.  39161  PhD Špela Bogataj  Cardiovascular system  Junior researcher  2016  81 
3.  01972  PhD Andrej Bren  Cardiovascular system  Researcher  2013 - 2016  507 
4.  10649  PhD Jadranka Buturović-Ponikvar  Cardiovascular system  Head  2013 - 2016  1,007 
5.  24053  PhD Jakob Gubenšek  Cardiovascular system  Researcher  2013 - 2016  338 
6.  01977  PhD Aljoša Kandus  Cardiovascular system  Researcher  2013 - 2016  553 
7.  20954  Mida Kandus    Technical associate  2013 
8.  06393  PhD Bojan Knap  Cardiovascular system  Researcher  2013 - 2016  366 
9.  12026  PhD Damjan Kovač  Cardiovascular system  Researcher  2013 - 2016  420 
10.  07764  PhD Jelka Lindič  Cardiovascular system  Researcher  2013 - 2016  432 
11.  06203  PhD Marko Malovrh  Cardiovascular system  Researcher  2013 - 2016  353 
12.  14581  PhD Andreja Marn Pernat  Cardiovascular system  Researcher  2013 - 2016  267 
13.  19576  PhD Gregor Mlinšek  Cardiovascular system  Researcher  2016  173 
14.  23258  PhD Jernej Pajek  Cardiovascular system  Researcher  2013 - 2016  349 
15.  28515  PhD Vanja Peršič  Cardiovascular system  Technical associate  2013 - 2016  104 
16.  01987  PhD Rafael Ponikvar  Cardiovascular system  Researcher  2013 - 2016  786 
17.  36616  Jasmina Žunić    Technical associate  2014 - 2016 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,903 
Abstract
1. Slovenian renal replacement therapy registry (Jadranka Buturović-Ponikvar) Slovenian renal replacement therapy registry provides provides an update of epidemiology and treatment practices in end-stage renal disease patients treated with renal replacement therapy  in Slovenia.   2. Proteinuria after kidney transplantation (Miha Arnol)  The objective of our study is to assess the prevalence of proteinuria in a national cohort of kidney transplant recipients, to evaluate type of proteinuria and its association with pathohistology and inflammatory markers in the blood and urine. 3. Quality of life in kidney graft recipients (Andrej Bren) Quality of life in kidney graft recipients would be assessed with standardized questionnaires with the aim to find out the most important factors of influence and to suggest the measures for improvement. 4. Treatment of acute humoral rejection in kidney graft recipients (Jakob Gubenšek) In our study we will analyze immediate and long-term treatment outcome of AMR, assess effectiveness of plasma exchange and potential side-effects. 5.  Conversion of stable renal transplant recipients from Prograf to Advagraf (Aljoša Kandus) In open, non-intervential, observational investigation conversion from Prograf (tacrolimu, twice daily) to Advagraf (tacrolimus, extended release, once daily) at equal daily dose will be accomplished in stable patients with renal transplant. The role of of antioxidant enzyme status in evaluating oxidative stress in dialysis patients (Bojan Knap) Oxidative stress would be assessed in dialysis patients. 7. Bone and vascular assessment in kidney graft recipients (Damjan Kovač) Analyzing metabolic and morphological factors and lifestyle of these patients we would like to evaluate the factors important in bone fracturing.Analyzing vascular function and arterial stiffness we would like to evaluate changes occurring after kidney transplantation.   Early predictors of kidney disease progression (Jelka Lindič) In patients with chronic kidney disease we would like to compare the conventional investigations for evaluation of kidney disease with some new markers of kidney disease activity in the 24-hour urine. We expect to discover new indicators of early kidney damage. 9. Long-term controlled treatment of secondary hyperparathyroidism with oral alfacalcidiol in hemodialysis patients (Marko Malovrh) Patients treated with chronic haemodialysis, we will follow the individual laboratory parameters during controlled alfacalcidol administered in oral form. We expect greater efficiency and therefore less need for additional treatment of secondary hyperparathyroidism.   10. Dyslipidemia treatment in kidney graft recipients (Gregor Mlinšek) Many transplanted patients have hyperlipidemia despite the treatment with statins. We want to do a research in order to assess the efficacy and safety of Tredaptive that will be added to statin. 11. Assessment of motor disabilities in dialysis patients (Jernej Pajek) We aim to integrally assess motor disabilities of dialysis patients with measurements of several motor abilities (strength, coordination, balance, flexibility, endurance) and dependance of disabilities on medical factors. The results will enable planning of motor and professional rehabilitation of dialysis patients. 12. Vascular access in elderly hemodialysis patients (Rafael Ponikvar) The most important features that enables creation of native arteriovenous fistula in the elderly hemodialysis patients would be analyzed. Ankle-brachial index in patients with chronic kidney disease (Andreja Marn-Pernat) The aim: To evaluate whether ankle brachial index is a good predictor of subclinical atherosclerosis in the Slovenian population of patients with chronic kidney disease stage 1-5, who have an increased risk for atherosclerosis.
Significance for science
Researchers of the Department of Nephrology, University Medical Center Ljubljana participate in the research program P3-0323 »Kidney diseases and renal replacement therapy«. They are active in research on chronic kidney disease, acute kidney injury and renal replacement therapy. Observational and interventional clinical studies in clinical nephrology, dialysis, transplantation and vascular access are principal areas of the research. Dr. Željka Večerić Haler, who completed her PhD in 2016 (co-mentor Miha Arnol) contributed to experimental research of our research group through her work on the role of mesenchymal cells in acute kidney injury in animal model. Research group of the Department of Nephrology has published 72 original papers from 2013-2016, completed 6 PhD and 3 MSc programs and training of the young researcher. Participation in the large international studies regarding dialysis in kidney transplantation continued. In 2016 program research group had important achievements: oral presentations on the most imporant international meetings were awarded and chosen among notable presentations, respectively (Jakob Gubenšek, Miha Arnol). Original research from transplantation was chosen among 5 excellent achievements in medicine from the Slovenian Research Agency. New research achievements are expected from 6 new PhD students (nephrology fellows) that has started PhD programme in the year 2016/2017, all mentored by researchers from our group. Another group of you PhD students will join next year (2017/2018), so it may be expected that our scientific productivity will increase in the next period.
Significance for the country
The level of health care for the patients with kidney diseases and renal replacement therapy in Slovenia is very high. Comparison with other countries in the quality parameters of dialysis and kidney transplantation shows that some important renal replacement therapy outcomes in Slovenia are significantly better than average in some developed coutries. In addition to clinical outcomes, intensive research through research program P3-0323 contributes to the improvement of the everyday clinical care of the patients with kidney diseases. With research, publications, presentations and invited lectures on international conferences and meetings, slovenian model of dialysis and transplantation is actively promoted as a potential model-to-follow for the country or region of similar size and transplant activity. Department of Nephrology at University Medical Center Ljubljana is becoming increasingly popular destination for the colleagues from the other countries, as a training center of certain skills in nephrology, dialysis and transplantation. All these activities are important in the view of free flow of patients through EU that is planned to be realized in future. Slovenia, with high quality of health care delivered for the patients with kidney diseases and need for renal replacement therapy may become desirable destination for the patients from other countries for certain health care services.
Most important scientific results Annual report 2013, 2014, 2015, final report
Most important socioeconomically and culturally relevant results Annual report 2013, 2014, 2015, final report
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