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Projects / Programmes source: ARRS

Protivirusne spojine: transport in interakcije v biosistemih (Slovene)

Research activity

Code Science Field Subfield
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
T410  Technological sciences  Pharmaceuticals and related technologies 
B740  Biomedical sciences  Pharmacological sciences, pharmacognosy, pharmacy, toxicology 
Keywords
antivirus compounds, partition coefficient, hydro-lipophilic properties, diffusion cells, Sweetana-Grass cells, absorption, biomucoadhesion.
Evaluation (rules)
source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  11124  PhD Marija Bogataj  Natural sciences and mathematics  Researcher  1999 - 2001  369 
2.  15623  PhD Matejka Burjak  Natural sciences and mathematics  Researcher  1996 - 2001  51 
3.  17432  Margareta Cof    Researcher  1999 - 2001 
4.  16107  PhD Iztok Grabnar  Natural sciences and mathematics  Researcher  1999 - 2001  425 
5.  01466  PhD Vojko Kmetec  Natural sciences and mathematics  Researcher  1996 - 2001  193 
6.  17434  Mihaela Kolarev    Researcher  1999 - 2001 
7.  00184  PhD Franc Kozjek  Natural sciences and mathematics  Researcher  1996 - 2001  486 
8.  11122  PhD Albin Kristl  Natural sciences and mathematics  Principal Researcher  1996 - 2001  347 
9.  17430  Nevenka Lilik    Researcher  1998 - 2001 
10.  06086  PhD Aleš Mrhar  Natural sciences and mathematics  Researcher  1996 - 2001  1,161 
11.  09066  PhD Stanislav Primožič  Natural sciences and mathematics  Researcher  1996 - 2001  302 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,115 
Abstract
The knowledge of physico-chemical and transport properties of the compounds as well as the connections and relationships among them enables the design of new drugs with optimal absorption behaviour. The properties of the drugs and epithelial barrier of the mucosa are therefore very important. Antivirus compounds of the analog series with designed hydro-lipophilic properties are used to study the kinetic of active and passive absorption process. The effects on transport kinetics and mechanism of different substances, which interact with mucus or mucosal epithelial membrane, are investigated too. The process of biomucoadhesion, which enables prolonged and better contact of a drug with the site of absorption (mucosa) and so improves the absorption and consequently the bioavailability, is also studied.
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