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Projects / Programmes source: ARIS

Eye diseases of adults and children

Periods
Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B620  Biomedical sciences  Ophtalmology 

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
Evaluation (rules)
source: COBISS
Researchers (20)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  28627  PhD Sofija Anđelić  Neurobiology  Researcher  2014 - 2018  76 
2.  22930  PhD Gregor Belušič  Biology  Researcher  2014 - 2018  218 
3.  04409  PhD Jelka Brecelj  Neurobiology  Researcher  2014 - 2016  347 
4.  21069  PhD Barbara Cvenkel  Medical sciences  Researcher  2014 - 2018  237 
5.  10397  PhD Kazimir Drašlar  Biology  Researcher  2014 - 2018  155 
6.  13674  PhD Brigita Drnovšek Olup  Neurobiology  Researcher  2014 - 2018  344 
7.  33340  PhD Ana Fakin  Neurobiology  Researcher  2014 - 2018  155 
8.  20707  PhD Mojca Globočnik Petrovič  Neurobiology  Researcher  2014 - 2018  259 
9.  09154  PhD Marko Hawlina  Neurobiology  Head  2014 - 2018  629 
10.  11537  PhD Polonca Jaki Mekjavič  Medical sciences  Researcher  2014 - 2018  380 
11.  16364  PhD Martina Jarc - Vidmar  Neurobiology  Researcher  2014 - 2018  202 
12.  39160  Luka Lapajne  Neurobiology  Junior researcher  2016 - 2018  39 
13.  29596  PhD Eva Lenassi  Medical sciences  Researcher  2014 - 2017  60 
14.  31971  PhD Jerneja Rudolf  Biology  Junior researcher  2014  11 
15.  09156  PhD Branka Stirn Kranjc  Neurobiology  Researcher  2014 - 2018  386 
16.  13675  PhD Mirna Štabuc Šilih  Medical sciences  Researcher  2014 - 2018  83 
17.  31505  PhD Špela Štunf  Neurobiology  Researcher  2014 - 2018  87 
18.  25616  PhD Maja Šuštar Habjan  Neurobiology  Researcher  2014 - 2018  120 
19.  20255  PhD Manca Tekavčič-Pompe  Neurobiology  Researcher  2014 - 2018  232 
20.  20708  PhD Nataša Vidovič Valentinčič  Neurobiology  Researcher  2014 - 2018  217 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,780 
2.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  66,799 
Abstract
In the next programme period, we would like to continue with the work charted in the period between 2009-2013. We would therefore like to keep the following parts of the program as follows: 1.DYSTROPHIES AND DEGENERATIONS AND INFLAMMATORY DISEASES OF UVEA, RETINA AND OPTIC NERVE (leader prof.dr.M.Hawlina)  We wish to continue the work with phenotype-genotype correlations and characterisation of retinal dystrophies and inherited optic neuropathies. Also we wish to continue the work on age related macular degeneration in the era of new anti VEGF agents. Also, we wish to continue our work on inflammatory eye diseases. 2.ELECTROPHYSIOLOGICAL FUNCTION OF THE RETINA AND VISUAL PATHWAY (leader: dr. J.Brecelj) With the newly developed electrophysiological methods, we wish to investigate cone dystrophies and define the extent of cone involvement in these. We also wish to elucidate the ganglion celll function in children with bilateral optic nerve hypoplasia, using new method of photopic negative response (PhNR) which can also be used in patients with unstable fixation. We also wish to assess the sensitivity of the new multifocal and color visual evoked potentials in patients with optic neuritis.  3.CLINICAL STUDIES OF CHILD'S VISION (leader prof.dr. B.Stirn-Kranjc) We wish to coninue to investigate a) changes of extraocular muscles in different diseases, b) sensory disturbances in congenital nystagmus c) clinical study of the disturbances in optic nerves, visual pathway with or without associated developmental disorders of the central nervous system and d) investigate the development of vision in premature infants with brain disorders to assess the risk factors according to their gestation age at birth.   4. CLINICAL AND ULRASTRUCTURAL CHARACTERISTICS OF THE CORNEA AND LENS (leader prof.dr. M.Hawlina) We wish to continue our studies of the cornea with the use of new laser optical coherence tomography of anterior eye segment. We also wish to continue investigations of ultrastructure of anterior lens capsule with scan electron microscopy.  5.DIABETIC RETINOPATHY (leader doc.dr.M. Globočnik Petrovič) We wish to assess the importance of inflammation in diabetic retinopathy. We would like to introduce analysis of inflammatory markers in vitreous body to assess postoperative outcome. With assessment of cell mediated inflammation and proinflammatory cytokines in the vitreous and in fibrovascular membranes in patients with PDR, we wish to assess the effects of inflammatory processes on visual function.   6.GLAUCOMA (leader doc.dr.B.Cvenkel) a) We wish to assess the effect of topical antiglaucoma treatment on ocular surface and analyse the effects of treatment on morphological and  immunohystochemical changes on the samples of exfoliative cytology of the conjunctiva.  b) Electrophysiology: We wish to asses the usefulness of new electrophysiological tests in different stages of glaucoma.  c) Pharmacogenomics in glaucoma:we wish to study genetic markers of the response to topical treatment with prostaglandine analogs, d) Selective laser trabeculoplasty (SLT): In patients  with open angle glaucoma we wish to assess morphological changes after SLT treatment with modified profile of laser beam in comparison to standard form of the beam.  7. INFLUENCE OF LASER IRRADIATION ON THE OCULAR AND PERIOCULAR TISSUES (leader prof.dr.B.Drnovšek-Olup) We wish to continue to study the effects, continue develpment and clinical use of lasers for dacryocystorhinostomy and YAG lasers for use in anterior segment of the eye.  8.TRANSLATION  EXPERIMENTAL STUDIES: (leaders: dr.S.Andjelić, dr.G.Belušič, prof.dr.M. Hawlina) We wish to continue the work on lens epithelial cells in different types of cataracts and mechanisms of cataractogenesis. We wish to introduce the techniques of culturing lens epithelial cells and corneal stem cells that are important in the treatment of severe thermal and chemical burns.
Significance for science
All proposed sections of the programme bring new scientific information of clinical importance. Scientific findings bring possibilities of better understanding of diseases and better diagnostics and treatment. Important aspects of very early diagnosis of retinal dystrophies and degenerations, diabetic retinopathy and glaucoma, diseases of the cornea and lens as well as in pediatric neuroophthalmic diseases, in which it may be possible to prevent the loss of vision. Research on genetic causes of these diseases are important for diagnosis and prognosis and hopefully, for genetic treatment when it becomes available. Research on laser irradiation on the ocular and periocular tissues is important to optimise the medical laser from the concepts to pre­clinical and clinical use. It is expected that the scientific findings obtained within this program will have direct impact on better diagnosis and treatment of ocular diseases.
Significance for the country
In Slovenia, our research programme brings new possibilities to introduce modern diagnostic and treatment methods. This is also important in obtaining new diagnostic equipment that is important for both, development of scientific methods as well as improvement of clinical applications. Results of use of new equiopment have been published in three issues of Slovenian Medical Journal, Zdravniški vestnik and the fouth one is going to be issued shortly. Introduction of new methods do have direct impact on the health of the population. Modern diagnostics and treatment offer immediate benefit to the patients whilst the genetic research brings understanding of slovenian types of mutations and although this may still be a long process, it promises to alleviate or at least slow down the progression of genetic diseases. it is also very important to have the opportunity to develop our medical research personnel as well as our dedicated technical staff.
Most important scientific results Annual report 2014, 2015, final report
Most important socioeconomically and culturally relevant results Annual report 2014, 2015, final report
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