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Projects / Programmes source: ARIS

Multifunctional electrospunned nanofibers development and dynamic interaction studies with pathogen bacteria

Research activity

Code Science Field Subfield
2.14.02  Engineering sciences and technologies  Textile and leather  Textile chemistry 

Code Science Field
P370  Natural sciences and mathematics  Macromolecular chemistry 

Code Science Field
2.05  Engineering and Technology  Materials engineering 
Keywords
nanofibers, electrospinning, wound healing, dynamic interaction, biofilm
Evaluation (rules)
source: COBISS
Researchers (31)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  32190  Sara Beigot Glaser  Microbiology and immunology  Technical associate  2016 
2.  25790  PhD Mojca Božič  Chemical engineering  Researcher  2016 - 2018  218 
3.  37632  PhD Matej Bračič  Chemistry  Researcher  2016 - 2018  145 
4.  19753  PhD Lidija Fras Zemljič  Textile and leather  Head  2016 - 2018  521 
5.  10842  PhD Matjaž Godec  Materials science and technology  Researcher  2016 - 2018  867 
6.  32545  PhD Matej Hočevar  Materials science and technology  Researcher  2016 - 2018  153 
7.  30755  PhD Sandra Janežič  Microbiology and immunology  Researcher  2016 - 2018  155 
8.  36303  PhD Rupert Kargl  Textile and leather  Researcher  2016 - 2018  288 
9.  18475  PhD Aleksandra Kocijan  Materials science and technology  Researcher  2016 - 2018  240 
10.  30203  Aleksander Kocuvan  Microbiology and immunology  Technical associate  2016 - 2018  28 
11.  02053  PhD Ivan Krajnc  Microbiology and immunology  Researcher  2018  615 
12.  39302  Tjaša Kraševac Glaser  Textile and leather  Researcher  2017 - 2018  18 
13.  04629  PhD Tatjana Kreže  Textile and leather  Researcher  2016 - 2018  276 
14.  24332  PhD Manja Kurečič  Materials science and technology  Researcher  2016 - 2018  227 
15.  30850  PhD Uroš Maver  Medical sciences  Researcher  2016 - 2018  448 
16.  33768  PhD Tamilselvan Mohan  Textile and leather  Researcher  2016 - 2018  208 
17.  10429  PhD Miran Mozetič  Electronic components and technologies  Researcher  2016 - 2018  1,348 
18.  29336  PhD Ilja Gasan Osojnik Črnivec  Chemistry  Researcher  2018  235 
19.  32474  PhD Ajda Ota  Animal production  Researcher  2016 - 2017  83 
20.  19268  PhD Zdenka Peršin Fratnik  Materials science and technology  Researcher  2016 - 2018  225 
21.  10873  PhD Nataša Poklar Ulrih  Chemistry  Researcher  2016 - 2018  827 
22.  34451  PhD Nina Recek  Biotechnology  Researcher  2016 - 2018  85 
23.  12278  PhD Maja Rupnik  Microbiology and immunology  Researcher  2016 - 2018  683 
24.  04171  PhD Majda Sfiligoj Smole  Textile and leather  Researcher  2016 - 2018  433 
25.  15466  PhD Mihaela Skrt  Biotechnology  Researcher  2016 - 2018  158 
26.  07814  PhD Karin Stana Kleinschek  Textile and leather  Researcher  2016 - 2018  1,116 
27.  32141  PhD Janja Stergar  Chemistry  Researcher  2017  122 
28.  10575  PhD Simona Strnad  Textile and leather  Researcher  2016 - 2018  370 
29.  07003  PhD Olivera Šauperl  Textile and leather  Researcher  2016 - 2018  408 
30.  20048  PhD Alenka Vesel  Electronic components and technologies  Researcher  2016 - 2018  686 
31.  37161  Tanja Vrabič  Microbiology and immunology  Technical associate  2016 - 2018 
Organisations (6)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  89,989 
2.  0206  Institute of Metals and Technology  Ljubljana  5051622000  5,935 
3.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  66,549 
4.  0795  University ob Maribor, Faculty of mechanical engineering  Maribor  5089638010  23,874 
5.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  15,989 
6.  3334  National Laboratory of Health, Environment and Foodstaffs  Maribor  6489087  4,700 
Abstract
Wound care management consumes a substantial proportion of healthcare budget of EU countries, including Slovenia. With an estimated prevalence of 1.48 patients/1,000 citizens and a population of 455 million in the European Union, this could translate to 673,000 patients costing 547 to 1,740 million euros per year. It is estimated that the treatment of all types of wounds may account for 2–4% of the total healthcare budget in each country. In addition, there is also a society cost in terms of an impact on patients by affecting their quality of life. Therefore, wound healing remains one of the most challenging clinical problems, and correct and efficient wound management is a priority of EU policy where human health, well-being and safe ageing are the key goals of 21st century. Much effort has been focused on wound care with an emphasis on new therapeutic approaches and the development of innovative technologies for acute and chronic wound management. New generation of medical textiles is an important growing field with great expansion in wound management products where ultrafine fibers and nanofibers due to their unique structural and functional properties have demonstrated the potential to revolutionize wound management. Although the number of research groups working on the development of new electrospun materials for tissue engineering and wound dressings is widely increasing, the task to effectively combine different natural antimicrobials and antioxidants into electrospun nano-mats remains challenging. The use of natural active agents is especially important because recent studies show that antibiotic-resistant bacteria represent an increasing concern in wound infections.  This project address the development of advanced multifunctional electrospunned nanofibers, manufactured from biodegradable polymers and natural extracts, that would provide structural and chemical support for wound repair with simultaneous antimicrobial and antioxidant functions and will offer great pharmaceutical potentials as bioresorbable antimicrobial material for enhanced wound care. Significantly, research would base on profound studies dealing with the interaction processes phenomena between antimicrobial/antioxidant biodegradable nanofibres and wound strains as biochemical wound environment. Basic findings will draw biomaterial characteristics vs. function relationships under biorelevant conditions. This project will potentially influenced on the development of new important textile/material science line; i.e. research of interactions between different microorganism/fungi, bacteria, viruses/ and solid complex heterogeneous systems such as functionalized fibre-forming polymers. There is still a large gap in the research field of interactions between bacterial and fungal systems and bioactive surfaces of polymeric materials (specially regarding biofilm problems) that are most frequently used in numerous advanced industrial branches. Finally, the knowledge obtained in this basic project will help to design and tune specific new fiber based nanomaterials applicable in different human care and health segments (wound treatment, skin & hygiene care, skin and gynaecological infections). In this way textile nanofibrous medical material development and textile industry segment will be strengthen.
Significance for science
The past succesfuly finished project L3-0361-0795 (consortium built from Faculty of Mechanical Engineering, Laboratory for Characterization and Processing of Polymers and National Institute of Health, Environment and Food) demonstrated the importance of understanding the appropriate antimicrobial testing for textile materials. However, this project was dealing with isolated problems concentrating on issue of antimicrobial fibre testing and its repeability, without deep understanding of interactions between bacteria and textiles. Thus proposed project is upgrading the previous one and will also help to clarify the complexity and difficulties of antimicrobial testing of heterogeneous fibre systems. Advanced multifunctional electrospunned nanofibers, manufactured from biodegradable polymers and natural extracts, that would provide advanced structural and chemical support for wound repair with simultaneous antimicrobial and antioxidant functions, will be developed and will offer great pharmaceutical potentials as bioresorbable antimicrobial material for enhanced wound care. In this way textile nanofibrous medical material development and textile industry segment will be strengthen. Furthermore, research would base on profound studies dealing with interaction processes phenomena between antimicrobial/antioxidant biodegradable nanofibres and wound strains as biochemical wound environment. Those phenomena will be clarified based on different colloidal chemistry model theories that will be upgraded and in this way generate significant new knowledge with respect to bio/non-bio interactions. This project will thus potentially influenced on the development of new important textile/material science line; i.e. research of interactions between different microorganism/fungi, bacteria, viruses/ and solid complex heterogeneous systems such as functionalized fibre-forming polymers. There is still a large gap in the research field of interactions between bacterial and fungal systems and bioactive surfaces of polymeric materials that are most frequently used in numerous advanced industrial branches. The basic project findings will draw biomaterial characteristics vs. function relationships under biorelevant conditions. Accordingly, these scientific contributions could be published representing fundamental and original scientific contributions within both national and international research fields. The results of projects will be published at international and national scientific conferences as well as integrated into master and doctoral thesis. The project group is planning to publish at least 5 scientific papers into the journals with the highest impact factor. In addition the research cooperation between all involved groups will be strengthening and the basis network for this kind of research topic for the future bigger projects within Horizon2020  and other national and EU programs will be initiated.
Significance for the country
The knowledge obtained in this basic project will help to design and tune specific new fiber based nanomaterials applicable in different human care and health segments as well as pharmachy (wound treatment, skin & hygiene care, skin and gynaecological infections). New functionalized materials will be result of an entirely domestic knowledge and experience and will be friendly products for environment and for costumer, respectively. The Slovenian companies such as Tosama d.o.o., Tekstina Ajdovščina d.d., Konus Konex d.o.o. express the interest for cooperation (as an outside partners) that may transfer this project knowledge into their industrial environments. Especially, Tosama that is already well known producer of wound dressing material may extend its potential products as gauzes, medical tampons, plasters etc., on the field of medicine and pharmacy, respectively. The knowlege may also be applied to other technical and domestic textiles segments such as clothes (Tekstina d.d. Ajdovščina ) and medical textiles  (Konus Konex d.o.o.). Those nanofibers can find its applications also in the mechanical and chemical industry which accounts for more than half of the total national market share. In addition, new technology based on the use of natural and biologically degradable substances; production will be performed without the use of expensive and harmful organic reagents, therefore the strictest European ecological regulations will be fulfiled.  Over the past few decades biofilm growth has been observed in many industrial and domestic domains. Unfortunately, in most cases the growth of biofilms has been detrimental. Thus the knowledge about biofilm formation as well as its sucessfill inhibition is cruical for several industries such as dairy, food, maritime, water systems, paper, opticians, dentistry as well as hospitals.  Consequently,  into a long term new jobs may be created (especiall for educated people).
Most important scientific results Interim report, final report
Most important socioeconomically and culturally relevant results Interim report, final report
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