Projects / Programmes
Biological characteristics of head and neck cancer and the results of treatment
| Code |
Science |
Field |
Subfield |
| 3.04.00 |
Medical sciences |
Oncology |
|
| Code |
Science |
Field |
| B007 |
Biomedical sciences |
Medicine (human and vertebrates) |
| B200 |
Biomedical sciences |
Cytology, oncology, cancerology |
Head and neck carcinoma, postoperative irradiation, Mitomycin C, Bleomycin, tumor biology
Researchers (9)
Organisations (2)
Abstract
Our prospective randomized study is aimed to compare two postoperative treatment regimens in patients who present with greater probability of recurrence due to the presence of unfavorable prognostic factors. The patients were randomized either into a group receiving postoperative irradiation alone (standard approach), or into a group treated by irradiation as well as chemotherapy (Mitomycin 15 mg/m2 after received 9-10 Gy radiation dose, and Belomycin 5 mg twice weekly). The proposed combination of postoperative therapy is expected to reduce the number of locoregional recurrences, and possibly improve the survival. It is further presumed that Bleomycin as a radiosensitizer of oxygenated cells should improve the effectivenes of postoperative radiotherapy, while an addition of Mitomycin C would enhance the therapeutic effect exerted on the residual hypoxic tumor cell population. The study will further investigate a possible correlation between certain tumor factors and prognosis of the disease. The randomization of patients will be completed in three years. By the end of the third year, it is expected that we should be able to draw some preliminary conclusions, while the final results will only be available two years after completed study.
