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Projects / Programmes source: ARIS

Applied and Basic Physiology and Pathophysiology in Medicine

Periods
Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
aging, neurodegeneration, cardiovascular disease, neurovascular coupling, oxidative stress, ROS, hyperglycemia, cell senescence, apoptoza, laser scanning confocal microscopy, molecular genetics, MRI, DWI, contrast agent, hyperbaric oxygenation, GABA, stem cell, translation medicine
Evaluation (rules)
source: COBISS
Points
7,074.91
A''
652.77
A'
1,918.03
A1/2
3,537.94
CI10
48,885
CImax
7,124
h10
57
A1
22.9
A3
4.74
Data for the last 5 years (citations for the last 10 years) on May 18, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender , archive )
Database Linked records Citations Pure citations Average pure citations
WoS  982  35,261  34,184  34.81 
Scopus  906  55,725  54,581  60.24 
Researchers (40)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  57206  Kanza Awais  Neurobiology  Junior researcher  2022 - 2024 
2.  20471  Dejan Bregar    Technical associate  2019  10 
3.  24927  PhD Miran Brvar  Neurobiology  Researcher  2019 - 2024  601 
4.  27580  PhD Klara Bulc Rozman  Neurobiology  Researcher  2019 - 2024  19 
5.  15667  PhD Matjaž Bunc  Neurobiology  Researcher  2019 - 2024  530 
6.  15243  PhD Ksenija Cankar  Cardiovascular system  Researcher  2019 - 2024  250 
7.  10779  PhD Rok Černe  Neurobiology  Technical associate  2020 - 2023  39 
8.  54659  Nina Demšar  Neurobiology  Junior researcher  2020 - 2024 
9.  08797  MSc Tatjana Drglin  Cardiovascular system  Technical associate  2019 - 2020  33 
10.  27577  PhD Andrej Fabjan  Neurobiology  Researcher  2019 - 2024  57 
11.  05232  PhD Žarko Finderle  Cardiovascular system  Researcher  2019 - 2024  158 
12.  21903  Alenka Frangež Štrukelj    Technical associate  2019 - 2024 
13.  29980  PhD Igor Darko Gregorič  Neurobiology  Researcher  2019 - 2020  206 
14.  51635  Barbara Hrast  Sport  Junior researcher  2019 - 2024 
15.  36087  Manja Hribar  Stomatology  Technical associate  2019 - 2024  32 
16.  15169  PhD Damijana Mojca Jurič  Neurobiology  Researcher  2019 - 2024  103 
17.  35358  Maja Justin  Neurobiology  Junior researcher  2019 
18.  16344  PhD Borut Kirn  Cardiovascular system  Researcher  2019 - 2024  62 
19.  55844  Lana Kralj  Cardiovascular system  Junior researcher  2021 - 2024  15 
20.  18322  PhD Helena Lenasi  Cardiovascular system  Researcher  2019 - 2024  186 
21.  05922  PhD Živa Melik  Cardiovascular system  Researcher  2019 - 2023  107 
22.  22642  Vesna Metelan    Technical associate  2019 
23.  18825  PhD Irina Milisav Ribarič  Neurobiology  Researcher  2019 - 2024  154 
24.  18549  PhD Aleksandra Milutinović Živin  Cardiovascular system  Researcher  2019 - 2024  125 
25.  55845  Iza Oblak  Neurobiology  Junior researcher  2021 - 2024 
26.  21413  PhD Damjan Osredkar  Human reproduction  Researcher  2019 - 2023  482 
27.  35892  Tina Pintar Tratnik    Technical associate  2020 - 2023 
28.  37609  PhD Tinkara Pirc Marolt  Microbiology and immunology  Junior researcher  2019 - 2022  18 
29.  05201  PhD Nejka Potočnik  Cardiovascular system  Researcher  2019 - 2024  136 
30.  51967  Patrik Prša  Neurobiology  Junior researcher  2019 - 2024  18 
31.  35604  Renata Radič Berglez    Technical associate  2019 - 2024 
32.  35603  Tina Robida    Technical associate  2019 - 2024  16 
33.  37994  Katja Romarić    Technical associate  2019 - 2024  15 
34.  36102  PhD Vladka Salapura  Medical sciences  Researcher  2019  275 
35.  07002  PhD Dušan Šuput  Neurobiology  Head  2019 - 2024  434 
36.  29977  Daša Šuput Skvarča  Microbiology and immunology  Technical associate  2022 - 2024  18 
37.  26268  PhD Andrej Vovk  Neurobiology  Researcher  2019 - 2024  52 
38.  18826  PhD Bojan Vrtovec  Medical sciences  Researcher  2019 - 2024  487 
39.  07797  PhD Rudolfina Zorc-Pleskovič  Cardiovascular system  Researcher  2019 - 2024  138 
40.  38240  PhD Gašper Zupan  Neurobiology  Technical associate  2020 - 2024  19 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,400 
Abstract
The research program aims at understanding the mechanisms of aging in the field of neurodegenerative diseases, neurovascular coupling and interactions between the neuronal function and cardiovascular system. Providing a broad spectrum of research methods and techniques and bringing together researchers from basic science and clinical research warrants successful interdisciplinary approach with horizontal and vertical integration of this very complex research field. Basic mechanisms of degeneration will be studied on cellular level such as cell cultures of neurons, astrocytes, neuron/astrocyte co-cultures, endothelial cells and hepatocytes using methods of biochemistry, molecular biology, micro-spectrofluorimetry and confocal microscopy. The main contribution to science will be identification of mechanisms of cellular damage by high glucose level, oxidative stress and drugs used for treatment of mental disorders. We will also study the effects of CO on neurons and astrocytes as well as the effects of hyperbaric oxygenation on cells and in vivo. Hyperbaric oxygenation and breathing pure oxygen will be used in the study of potential use of oxygen as a contrast agent in MR imaging. Several contrast agents based on Gd salts have already been banned, and especially in the elderly a risk of renal failure caused by Gd is relatively high. MR imaging will be used in the study of neurodegenerative disorders and in following the outcome of stem cell therapy of cardiomyopathy. Neurodegeneration and cardiovascular disease are the hallmark of aging process, and they share several causative mechanisms. Hyperglycemia is involved in both processes. Effects of acute hyperglycemia will be studied on cell cultures and in vivo on patients with diabetes type I. Those effects are poorly known, but may have a profound effect on brain function and structure. Hyperglycemia is also involved in micro and macroangiopathies as well as in heart failure. We will continue our research in the treatment of dilatative cardiomyopathy with stem cells and follow up by using cardiac MRI. MRI is a safe and effective method to study nervous and cardiovascular system in health and disease. It has excellent space and time resolution and another MR based method, MR spectroscopy (MRS), provides simultaneous information on chemical composition of investigated tissue. We will use both MRI and MRS methods to study neurodegeneration. Especially in the case of Parkinson’s disease introduction of novel techniques such as STIR and quantitative susceptibility mapping (QMS) greatly enhances the resolution of MR images of substantia nigra. In all neurodegenerative and mental disorders MRS provides a deeper insight in the process of neurodegeneration. In collaboration with research team at Johns Hopkins, USA, we can now measure glutamate, glutamine and GABA in brain regions in addition to metabolites detected by standard MRS.
Significance for science
The research program will provide new knowledge of the mechanisms of cell senescence and aging in the field of neurodegenerative diseases, neurovascular coupling and interactions between the neuronal function and cardiovascular system. Bringing together researchers from the field of molecular biology all the way to clinical research and providing a broad spectrum of research methods and techniques available within the program group warrants a successful interdisciplinary approach. Interdisciplinary approach enabling horizontal and vertical integration of this very complex research field is one of the strongest points of the program. Basic mechanisms of degeneration will be studied on cellular level such as primary cell isolation and cell cultures of neurons, astrocytes, neuron/astrocyte cocultures, endothelial cells and hepatocytes using methods of biochemistry, molecular biology, micro-spectrofluorimetry and confocal microscopy. The main contribution to science will be identification of mechanisms of cellular damage by high glucose level, oxidative stress and two drugs used for treatment of mental disorders. We will also study the effects of CO poisoning on neurons and astrocytes as well as the effects of hyperbaric oxygenation on cells and in vivo. Hyperbaric oxygenation and breathing pure oxygen will be used in the study of potential use of oxygen as a contrast agent in MR imaging. Several contrast agents based on Gd salts have already been banned, and especially in the elderly a risk of renal failure caused by Gd is relatively high. MR imaging will be used in the study of neurodegenerative disorders and in following the success of stem cell therapy of dilatative cardiomyopathy. Neurodegeneration and cardiovascular disease are the hallmark of aging process, and they share several causative mechanisms. Hyperglycemia is involved in both processes. Effects of acute hyperglycemia will be studied on cell cultures and in vivo on patients with diabetes type I. Those effects are poorly known, but may have a profound effect on brain function and structure. Hyperglycemia is also involved in micro and macroangiopathies as well as in heart failure. We will continue our research in the treatment of dilatative cardiomyopathy with stem cells and follow up by using cardiac MRI. MRI is a safe and effective method to study nervous and cardiovascular system in health and disease. It has excellent space and time resolution and another MR based method, MR spectroscopy (MRS), provides simultaneous information on chemical composition of investigated tissue. We will use both MRI and MRS methods for study of neurodegeneration. Especially in the case of Parkinson's disease the introduction of novel techniques such as STIR and quantitative susceptibility mapping (QMS) greatly enhances the resolution of neuromelanin imaging in substantia nigra. In all neurodegenerative and mental disorders MRS provides a deeper insight in the process of neurodegeneration. Standard MRS provides information on a few metabolites and transmitters, but using MEGA-PRESS sequence and appropriate post-processing (provided by a collaborator from Johns Hopkins, USA) we can also measure the neurotransmitter GABA and provide more accurate measurements of glutamate glutamine. We are sure that our contribution to science will be evident from several publications in high ranking journals.
Significance for the country
The organisation and results of the program group are important for the development of science for several reasons. The combination of complementary research methods and collaboration of researchers from basic science with clinical researchers warrants translation of basic research results into clinical practice. This approach enables engagement in relevant research that contributes to the understanding of a disease and provides clues for therapeutic approaches. In the past we have already shown practical results by introduction new MRI an MRS methods, introduction of cell therapy in cardiomyopathy, use od left ventricular assist device (LVAD) in collaboration with UT, Houston, TX and study of the effects of laminar flow on microcirculation and autonomic nervous system. Our research has also potential impact on economic development. We have produced prototypes of devices, developed new software and filled several patents. Together with collaborators from NIH, Bethesda, USA, our young researcher has developed an innovative approach for automatic segmentation of brain form MR images. Translation of research into practice is also evident from international (US) patent that is already in use by US company CardioSoft, and Slovenian patent for a device to monitor optical nerve microcirculation during neurosurgery. Our researchers are deeply involved in health care system by implementing new knowledge, techniques and approaches for the benefit of individual patients and the population. Publishing in top journals in the field and involvement in executive committees of international professional organizations is important for the promotion of the country. We are also dedicated to excellence in undergraduate, graduate and postgraduate and in the professional development of our staff. Collaboration in international projects and working together with international companies and researchers provides new opportunities and exchange of knowledge. Our goal is to continue with these activities and contribute to the development of science and society.
Most important scientific results Interim report
Most important socioeconomically and culturally relevant results Interim report
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