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Projects / Programmes source: ARIS

Slovenian network of allergy and asthma: from epidemiology to genetics

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Periods
January 1, 2019 - December 31, 2024
Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   
3.08.00  Medical sciences  Public health (occupational safety)   

Code Science Field
B500  Biomedical sciences  Immunology, serology, transplantation 

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
3.03  Medical and Health Sciences  Health sciences 
Keywords
severe asthma, IgE senzibilation, anaphylaxis, recombinant allergens, biological therapies, genetics of allergic diseases, basophils, mast cells
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Points
8,513.99
A''
2,023.67
A'
3,281.86
A1/2
4,849
CI10
43,457
CImax
2,723
h10
84
A1
29.53
A3
4.91
Data for the last 5 years (citations for the last 10 years) on December 10, 2023; A3 for period 2017-2021
Data for ARIS tenders ( 04.04.2019 – Programme tender , archive )
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Database Linked records Citations Pure citations Average pure citations
WoS  844  41,680  40,636  48.15 
Scopus  727  50,492  49,369  67.91 
Researchers (32)
no. Code Name and surname Research area Role Period No. of publications
1.  25169  PhD Urška Bidovec Stojkovič  Microbiology and immunology  Researcher  2019 - 2023  104 
2.  39674  PhD Mojca Bizjak  Microbiology and immunology  Researcher  2020 - 2023  109 
3.  12179  PhD Tanja Čufer  Oncology  Researcher  2019 - 2020  773 
4.  51978  Jerneja Debeljak  Microbiology and immunology  Researcher  2019 - 2023  20 
5.  53537  Ajda Demšar Luzar  Microbiology and immunology  Junior researcher  2019 - 2023  9 
6.  25171  PhD Renato Eržen  Microbiology and immunology  Researcher  2019 - 2021  260 
7.  15710  PhD Matjaž Fležar  Cardiovascular system  Researcher  2019 - 2023  550 
8.  20616  PhD Saša Kadivec  Public health (occupational safety)  Researcher  2019 - 2023  381 
9.  29281  PhD Lea Knez  Pharmacy  Researcher  2019 - 2023  189 
10.  30983  PhD Peter Kopač  Microbiology and immunology  Researcher  2020 - 2023  246 
11.  34101  PhD Ana Koren  Microbiology and immunology  Researcher  2019 - 2023  86 
12.  22807  PhD Peter Korošec  Microbiology and immunology  Researcher  2019 - 2023  697 
13.  10921  PhD Mitja Košnik  Microbiology and immunology  Head  2019 - 2023  1,539 
14.  57228  Gloria Krajnc  Microbiology and immunology  Technical associate  2022 - 2023  0 
15.  02053  PhD Ivan Krajnc  Microbiology and immunology  Researcher  2019 - 2023  615 
16.  30987  PhD Nika Lalek  Microbiology and immunology  Researcher  2020 - 2023  49 
17.  34498  PhD Dane Lužnik  Microbiology and immunology  Researcher  2019 - 2023  36 
18.  23464  PhD Mateja Marc Malovrh  Microbiology and immunology  Researcher  2019 - 2023  168 
19.  15780  PhD Robert Marčun  Cardiovascular system  Researcher  2019 - 2023  213 
20.  06630  PhD Pika Meško Brguljan  Biochemistry and molecular biology  Researcher  2019 - 2023  344 
21.  51977  Maruša Rihar  Microbiology and immunology  Junior researcher  2019 - 2023  0 
22.  29300  PhD Matija Rijavec  Microbiology and immunology  Researcher  2019 - 2023  271 
23.  25177  PhD Aleš Rozman  Oncology  Researcher  2019 - 2023  505 
24.  28517  PhD Eva Sodja  Oncology  Researcher  2019 - 2023  64 
25.  56315  Manca Svetina  Microbiology and immunology  Junior researcher  2022 - 2023  8 
26.  29763  MSc Irena Šarc  Cardiovascular system  Researcher  2020 - 2023  163 
27.  36479  PhD Julij Šelb  Oncology  Researcher  2021 - 2023  108 
28.  25178  PhD Sabina Škrgat  Microbiology and immunology  Researcher  2019 - 2020  319 
29.  22806  PhD Viktorija Tomič  Microbiology and immunology  Researcher  2019 - 2023  416 
30.  39238  Romana Vantur Setnikar  Microbiology and immunology  Junior researcher  2019 - 2021  16 
31.  25317  PhD Mihaela Zidarn  Public health (occupational safety)  Researcher  2019 - 2023  435 
32.  07627  PhD Marija Žolnir-Dovč  Microbiology and immunology  Researcher  2019 - 2023  302 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  1613  University Clinic of Respiratory and Allergic Diseases  Golnik  1190997  7,157 
2.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  16,251 
Abstract
In the integration part we will study the epidemiology of anaphylaxis and severe asthma in Slovenia. The research activities will be perform in five WPs. In WP 1 we will focus on airway remodeling in severe asthma (WP 1.1) and on the cellular and molecular changes in different asthma endotypes (WP 1.2). In large WP of IgE senzibilization and anaphylaxis (WP 2) we will study the link between specific IgEs, basophils and allergic disease. In this part we will in detail study the role of basophils in anaphylaxis (WP 2.1) and testing the correlation between basophil sensitivity and induction of tolerance during the specific immunotherapy (WP 2.2) and the correlation between basophil sensitivity and the severity of systemic allergic reaction (WP 2.3). In a third WP we will study the recombinant allergens (WP 3). In this part we will evaluate the biological activity of recombinant allergens (WP 3.1), especially those ones, which are important for the diagnosis of anaphylaxis (WP 3.2). The fourth WP is focused on biological therapies. In this WP we will monitor the molecular and cellular changes during anti-IgE (WP 4.1), anti IL-5 (WP 4.2) or anti TSLP (WP 4.3) therapy. Those data will be compared with the clinical response. The fifth large WP is focused on the genetics of the allergic diseases (WP 5). In WP 5.1 we will study the genetic background of anaphylaxis with the focus on tryptase gene TPSAB1 and somatic mutations related to mastocytosis. In the most complex genetic part we will perform whole transcriptomic analysis during the anaphylactic reaction in different clinical and experimental animal models (WP 5.2). We will also perform genotype – phenotype studies in different patients with the focus on the hereditary angioedema (WP 5.3).
Significance for science
Asthma and allergies are the most common chronic diseases in developed countries. Their prevalence is still increasing and is approaching 50% (patients suffering from any allergy anytime in their lifetime). Several hypotheses are discussed, such as the evolution of the »western lifestyle«, the hygiene hypothesis, and environmental changes. An important part in the development of allergies is genetics. We are currently facing two challenges. The first one is that we need to define the cause of the increasing prevalence which might lead to prevention. The second one is to define the exact mechanisms causing allergy symptoms which could result in a more efficient diagnostic approach and a more successful treatment. Only a half of those with allergen specific IgE actually develop symptoms. In case of anaphylaxis, as little as 10% of sensitized patients develop symptoms. Furthermore, it is unclear why some subjects with comparable specific IgE levels might develop only mild symptoms or a life-treating anaphylaxis. We still have not found biomarkers indicating which sensitized subjects are at risk for the development of life-threatening allergic reactions.                   Another important question is the exact mechanism behind specific immunotherapy, as it is still poorly understood. There are no in vitro tests to correctly predict treatment success. This research programme plans to study the above mentioned questions, causes for those differences as well as possible mechanisms in terms of recombinant allergens, by measuring the sensitivity of effector cells (basophils, mast cells), and in terms of genetics (incl. expression). Program group members are certain that the program will yield great results with an important effect on the development of science and improved visibility of Slovenia in this field.
Significance for the country
The current research program titled “Slovenian Allergy and Asthma Network: from Epidemiology to Genetics« has brought together different health institutions and medicine areas in Slovenia (pneumology, immunology, otorhinolaryngology, epidemiology and family medicine). The result of this program is an effective national research platform that complies with the standards of excellence and already connects Slovenian and foreign researchers. The results of our research have achieved great international recognition. They have been published in the most influential allergy and clinical immunology journals. In addition to the promotion of Slovenian science, we have also achieved partnerships in joint projects with the leading research centers in Europe and USA. We are proud to be involved in the development of allergy and clinical immunology at the international level. The program has a direct impact on the development of society, as it accelerates the use of research results in clinical practice and provides assistance in the management of research development policy in Slovenia. It also promotes teaching, education and better integration in this field. The program is based on an integrated approach, and one of its most important goals is to improve the quality of patients’ lives by reducing the burden of allergic diseases in Slovenia.
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