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Projects / Programmes source: ARIS

Celostna obravnava alergijskih bolezni in astme v Sloveniji: od epidemiologije do genetike (Slovene)

Periods
Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Evaluation (rules)
source: COBISS
Researchers (16)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  34096  PhD Nanča Čebron Lipovec  Pharmacy  Junior researcher  2012  75 
2.  32076  PhD Nina Čelesnik Smodiš  Biochemistry and molecular biology  Junior researcher  2009 - 2012  46 
3.  33191  PhD Katja Čvan Trobec  Cardiovascular system  Junior researcher  2010 - 2012  30 
4.  15710  PhD Matjaž Fležar  Cardiovascular system  Researcher  2009 - 2012  556 
5.  27968  PhD Irena Grmek Košnik  Microbiology and immunology  Researcher  2009 - 2012  378 
6.  20616  PhD Saša Kadivec  Public health (occupational safety)  Researcher  2009 - 2012  388 
7.  22807  PhD Peter Korošec  Microbiology and immunology  Researcher  2009 - 2012  738 
8.  10921  PhD Mitja Košnik  Microbiology and immunology  Head  2009 - 2012  1,581 
9.  22680  PhD Mitja Lainščak  Cardiovascular system  Researcher  2009 - 2012  719 
10.  34498  PhD Dane Lužnik  Microbiology and immunology  Junior researcher  2011 - 2012  38 
11.  23464  PhD Mateja Marc Malovrh  Microbiology and immunology  Researcher  2009 - 2012  190 
12.  16252  PhD Jovan Miljković  Microbiology and immunology  Researcher  2009 - 2012  262 
13.  00288  PhD Ema Mušič  Microbiology and immunology  Researcher  2009 - 2012  489 
14.  23375  PhD Brigita Skela Savič  Public health (occupational safety)  Researcher  2009 - 2012  1,053 
15.  18035  PhD Pavel Skok  Metabolic and hormonal disorders  Researcher  2009 - 2012  681 
16.  07627  PhD Marija Žolnir-Dovč  Microbiology and immunology  Researcher  2009 - 2012  303 
Organisations (4)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  23,106 
2.  1613  University Clinic of Respiratory and Allergic Diseases  Golnik  1190997  7,240 
3.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  15,954 
4.  2672  FACULTY OF HEALTH CARE JESENICE  Jesenice  2245272  5,466 
Significance for science
Our research program is excellent in three particular fields. The first one is airway angiogenesis, which is an important part of structural remodeling in the pathogenesis of asthma. Namely, we recently showed significantly increased airway angiogenesis in corticosteroid-treated and well-controlled asthma patients. That means that with regard to remodeling, the standard therapy is not optimal. We are currently testing different angiogenesis-related factors in order to show which targets could be the most appropriate for the new generation of drugs for obstructive lung diseases. Another field is aspirin intolerance, which is the most common drug adverse reaction, but with an unknown mechanism. In that field we are testing the possible pathogenic role of COX-2 overexpression. Our most comprehensive field is the relation between IgE sensitization and allergic disease. Firstly, the synthesis of allergen-specific IgE is required for the development of allergic diseases, but around one third of individuals with allergen-specific IgE do not develop symptoms. Secondly, the result of immunotherapy is diminishing of the clinical disease, but the sensitization remains. We hypothesize that the clinically relevant sensitization is related to high allergen sensitivity of effectors’ cells, such as basophils and mast cells; and vice versa – if this allergen sensitivity is low there is no disease despite sensitization. We tested this hypothesis in different clinical models, from venom to birch and grass pollens and to dust mite immunotherapy, and recently also in an in vivo provocation assay as well as in the symptom scores monitoring during the pollination season. We showed that the background for different basophil allergen sensitivity and related clinical presentation of disease was diverse and it included blocking IgG antibodies induced by immunotherapy, the size of disease-relevant specific IgE antibodies, transduction cellular element of degranulation and the possible influence of T regulatory cells. We recently also showed the possible role of the Fc?RI down-regulation.
Significance for the country
We want to tackle the fragmentation of Slovenian research in the field of allergy and asthma by building a durable research platform and setting up a nationwide epidemiological study and a patient register. Our initial integration activity was an asthma prevalence study. In the first part we used core questionnaires (N = 687) followed by an outpatient clinical examination in selected subjects (N = 185). In the second part we used supplementary questionnaires for prevalence estimations (N = 1145). We showed a high asthma prevalence of 16.3%. This prevalence group and two other groups (asthma and atopic dermatitis) were also genetically tested. Genetic background of allergic diseases in Slovenian population is important for the planning of the next generation of therapy and for pharmacogenomic evaluation. We significantly raised public awareness with the questionnaire-based study about the safety of allergic children in Slovenian kindergartens and schools. Other major goals of the program were to accelerate the application of research results into clinical practice to meet the needs of patients, and to help guide policy development. We also promote trainings like asthma schools (asthma school is organized 4 times per year), and the integration of other medical expertise, such as dermatology and otolaryngology. By addressing allergy and asthma in their totality, the program’s ultimate objective is to benefit the well-being of patients by decreasing the burden of allergic diseases in Slovenia.
Most important scientific results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, final report, complete report on dLib.si
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