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Projects / Programmes source: ARIS

Napovedni pomen proteinov uPA sistema in katepsinov za prezivetje in odgovor na sistemsko zdravljenje bolnic z rakom dojk (Slovene)

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B520  Biomedical sciences  General pathology, pathological anatomy 
Keywords
uPA-system proteins, cathepsins, prognostic markers, predictive markers, breast cancer
Evaluation (rules)
source: COBISS
Researchers (17)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  16303  PhD Simona Borštnar  Oncology  Researcher  2002  502 
2.  08616  PhD Matej Bračko  Oncology  Researcher  2000 - 2002  197 
3.  15832  Olga Cerar  Oncology  Researcher  2002  100 
4.  03289  Jožica Červek  Oncology  Researcher  2002  205 
5.  12179  PhD Tanja Čufer  Oncology  Head  2000 - 2002  775 
6.  02686  PhD Rastko Golouh  Oncology  Researcher  2002  364 
7.  20051  PhD Monika Jagodic  Oncology  Researcher  2002  32 
8.  15834  PhD Tanja Južnič Šetina  Oncology  Researcher  2002  59 
9.  12224  PhD Borut Kragelj  Oncology  Researcher  2002  81 
10.  20055  PhD Erika Matos  Oncology  Researcher  2002  197 
11.  15835  MSc Bojana Pajk  Oncology  Researcher  2002  86 
12.  20056  PhD Martina Reberšek  Oncology  Researcher  2002  264 
13.  08750  PhD Zvonimir Rudolf  Oncology  Researcher  2002  258 
14.  08800  PhD Gregor Serša  Oncology  Researcher  2002  1,520 
15.  13157  PhD Breda Škrbinc  Oncology  Researcher  2000 - 2002  108 
16.  07195  PhD Ivan Vrhovec  Oncology  Researcher  2002  116 
17.  11747  PhD Branko Zakotnik  Oncology  Researcher  2002  425 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,816 
Abstract
The prognosis of breast cancer patients depends very much on the ability of tumor cells to invade the surrounding tissue and to metastasize. According to the data published so far tumor-associated proteases and their inhibitors play a major role in the above mentioned processes. The aim of our study is to determine the prognostic value o uPA-system proteins, cathepsins D and L and their various combinations for survival of breast cancer patients as well as to determine whether the expression of uPA-system proteins and cathepsins in primary tumor can predict for the effectiveness of adjuvant systemic treatment. We expect that the measurement of different proteases and their inhibitors in primary tumor would allow for a better selection of patients which could benefit from therapy. In addition, on the basis of confirmed predictive value of different proteases and their inhibitors for response to adjuvant therapy a better selection of treatment for each individual patient would be possible leading to a better effectiveness of therapy and improved survival of patients.
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