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Projects / Programmes source: ARIS

New method for estimating life-years gained in population-based cancer screening programmes (S-LYG)

Research activity

Code Science Field Subfield
3.08.00  Medical sciences  Public health (occupational safety)   

Code Science Field
3.03  Medical and Health Sciences  Health sciences 
Keywords
population-based cancer screening programmes, life-years gained, survival analysis, cancer registry, cervical cancer, breast cancer, colorectal cancer
Evaluation (rules)
source: COBISS
Points
6,405.97
A''
752.04
A'
2,398.88
A1/2
3,960.81
CI10
41,549
CImax
8,851
h10
60
A1
21.83
A3
9.45
Data for the last 5 years (citations for the last 10 years) on July 23, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Database Linked records Citations Pure citations Average pure citations
WoS  588  32,954  32,161  54.7 
Scopus  551  42,581  41,738  75.75 
Researchers (25)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  55104  Mojca Birk  Oncology  Researcher  2021 - 2024  15 
2.  30722  PhD Rok Blagus  Systems and cybernetics  Researcher  2020 - 2024  203 
3.  54404  Nika Bric  Oncology  Researcher  2021 - 2024  23 
4.  51190  Mojca Dolinar    Technical associate  2020 - 2023 
5.  32519  PhD Urška Ivanuš  Oncology  Researcher  2020 - 2024  295 
6.  36525  PhD Katja Jarm  Oncology  Researcher  2020 - 2024  129 
7.  38871  Tine Jerman  Oncology  Researcher  2020 - 2024  56 
8.  26484  PhD Andrej Kastrin  Medical sciences  Researcher  2020 - 2024  151 
9.  15543  Tatjana Kofol Bric  Public health (occupational safety)  Researcher  2020 - 2024  182 
10.  56197  Tina Košuta  Medical sciences  Researcher  2022 - 2023 
11.  27594  PhD Mateja Krajc  Medical sciences  Researcher  2020 - 2024  383 
12.  24477  Katarina Lokar  Medical sciences  Researcher  2020 - 2024  186 
13.  51959  PhD Damjan Manevski  Public health (occupational safety)  Researcher  2022 - 2023  42 
14.  54214  Ana Mihor  Medical sciences  Researcher  2021 - 2024  56 
15.  32843  Miran Mlakar  Medical sciences  Researcher  2020 - 2024 
16.  29120  PhD Dominika Novak Mlakar  Public health (occupational safety)  Researcher  2020 - 2024  126 
17.  23437  PhD Maja Pohar Perme  Public health (occupational safety)  Researcher  2020 - 2024  293 
18.  23657  Lidija Pollak  Political science  Technical associate  2023 - 2024 
19.  33230  PhD Nina Ružić Gorenjec  Mathematics  Researcher  2020 - 2024  52 
20.  08992  PhD Janez Stare  Public health (occupational safety)  Researcher  2020 - 2024  279 
21.  54299  Ana Lucija Škrjanec  Public health (occupational safety)  Researcher  2021 - 2024  12 
22.  30641  Sonja Tomšič  Public health (occupational safety)  Researcher  2020 - 2024  198 
23.  23050  PhD Vesna Zadnik  Public health (occupational safety)  Head  2020 - 2024  512 
24.  11747  PhD Branko Zakotnik  Oncology  Retired researcher  2020 - 2024  425 
25.  25531  PhD Tina Žagar  Oncology  Researcher  2020 - 2024  243 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,793 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,762 
3.  3333  National Institut of Public Health  Ljubljana  6462642  18,754 
Abstract
BACKGROUND At the population level, the benefits of organized cancer screening programmes are reflected in reduced incidence and mortality. Though we have most of the necessary information to monitor the effectiveness of screening programmes, the effectiveness measures that are currently in place are insufficient. Classical indicators are available too late (mortality) or else their calculations are subject to biases that limit their usability (survival). PURPOSE AND OBJECTIVES The aim of the project is to contribute to further reducing the burden of cervical, breast and colrectal cancers both in Slovenia and abroad by developing a new method that will enable organised screening programmes to more strategically and quickly adapt screening policy to the real-world situation. Project objectives: Develop a new S-LYG method that will allow faster monitoring of the screening programme effectiveness without the common biases not corrected for within existing methods. This will allow for better management of the programme and faster introduction of changes to the screening policy - either when establishing new organised screening programmes or when changing the screening policies of existing programmes.Test the new method via linking data from all three cancer screening registries and the national Cancer Registry.Reduce the complexity of calculating the new indicator and set a minimum data set so as to increase the usability of the method in everyday practice. CONTENT As part of the proposed project, we will develop a new S-LYG method based on the calculation of the life years gained in persons who responded to screening invitation compared with those who did not. We will overcome lead time and length time biases by appropriately defining the start of follow-up and the (observed) outcome. Within the framework of the project, the S-LYG method will be tested using real data from all three of Slovenia's national cancer screening programmes: ZORA (cervical cancer), DORA (breast cancer), and Svit (colorectal cancer). These will be linked to the population-based cancer registry. The test example will be very demanding to perform due to differences between screening programmes in target groups, invitation practices and effects, and will promptly reveal potential shortcomings of the method that will need to be corrected/eliminated. Furthermore, we will adapt the S-LYG method to use on a minimum set of routinely collected data (aS-LYG) from population registers, mortality tables and already established periodic screening programme indicators, such as the number invited and participation rates by gender, age and calendar year. We will pay particular attention to the feasibility of introducing the adjusted aS-LYG as a new indicator for the effectiveness of screening programmes, which could then be included in rutine reporting. EXPECTED RESULTS The new S-LYG/aS-LYG method will allow for an unbiased and up-to-date calculation of the number of life years gained among persons who responded to the screening invitation. S-LYG will be useful in the management of screening programmes, their promotion and in evaluation of the effects of changes in screening policies, while it may also be used in decision making regarding the introduction of new screening programmes. ORGANISATION AND FEASIBILITY OF THE PROJECT The research team of the proposed project includes heads from the ZORA, DORA and Svit screening registries as well as from the population-based Slovenian Cancer Registry, who are experts in cancer epidemiology and cancer screening as well as the internationally recognised team of medical biostatistics experts at the Institute for Biostatistics and Medical Informatics of the University of Ljubljana, for whom survival analysis is a core topic of methodological research. Thus, we have brought together a unique team of researchers on a worldwide scale, who have at their disposal all the necessary data, knowledge, software and hardware to achieve the se
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