Projects / Programmes
Macromolecular Chemisty -
January 1, 1999
- December 31, 2003
Code |
Science |
Field |
Subfield |
1.04.00 |
Natural sciences and mathematics |
Chemistry |
|
2.04.00 |
Engineering sciences and technologies |
Materials science and technology |
|
Code |
Science |
Field |
P360 |
Natural sciences and mathematics |
Inorganic chemistry |
P370 |
Natural sciences and mathematics |
Macromolecular chemistry |
P390 |
Natural sciences and mathematics |
Organic chemistry |
T390 |
Technological sciences |
Polymer technology, biopolymers |
T490 |
Technological sciences |
Biotechnology |
Researchers (24)
Organisations (1)
Abstract
The present research program deals with several basic and applied aspects of inorganic and organic macromolecular chemistry. Chemical modifications of organic polymers can be used to tailor a number of new properties of high molecular substances. Imobilization of reagents and catalysts onto soluble and insoluble polymeric carriers will be carried out. Influence of the structure of polymeric carrier (polystiren, polyvinilpyridin, polystiren-acrilate), of the basic unit and of the reagent, on the properties and reactivity of new reagents and catalysts will be studied. The influence of structural parameters will be investigated using basic organic reactions: substitution, addition, elimination. The influence of reaction conditions (polarity of the medium, swelling of reagents and catalysts, steric interactions substrat-reagent) on transformations of organic molecules will be evaluated. Additional scope of the mentioned polymeric carriers is the preparation of macromolecules, which can to be used as interaction sorbents for the separation or binding of enzimes. Binding of metal ions to naturally occuring macromolecules is of outstanding importance in living systems. Metal ions have vital functions in biological systems, in additon, as metal complexes they are used in chemotherapy. The synthesis and characterization of new platinum coordination compounds, potentially applicable as anticancer or antiviral agents will be carried out. The relation between cis-trans isomers and their chemotherapeutic activity will be evaluated. Also the interactions between metal ions on one side, and clinically proved agents as quinolones, and natural macromolecules as hyaluronic acid on the other side, will be studied. Sol-gel chemistry of inorganic precursors represent one of the most promising routes for the synthesis of inorganic materials, where controlled polycondenzation is used. Oxide materials will be prepared with sol-gel synthesis. Structural and electrochemical characteristics, which are essential for their electrochromic properties will be evaluated.
Most important scientific results
Final report
Most important socioeconomically and culturally relevant results
Final report