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Projects / Programmes source: ARIS

Structure and function of dermatophyte proteinases and their protein inhibitors.

Research activity

Code Science Field Subfield
4.04.00  Biotechnical sciences  Veterinarian medicine   

Code Science Field
B750  Biomedical sciences  Veterinary medicine: surgery, physiology, pathology, clinical studies 
P310  Natural sciences and mathematics  Proteins, enzymology 
Keywords
dermatophytes, proteinases, proteinase inhibitors, immune response, chromatography
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15595  Katarina Babnik    Technical associate  2002 - 2005 
2.  22356  PhD Katja Benčina  Chemistry  Junior researcher  2003 - 2005  53 
3.  21407  PhD Sabina Berne  Biotechnology  Researcher  2005  165 
4.  07850  PhD Marinka Drobnič-Košorok  Veterinarian medicine  Head  2002 - 2005  185 
5.  11780  PhD Nevenka Kožuh Eržen  Pharmacy  Researcher  2002 - 2005  160 
6.  12728  PhD Aleš Podgornik  Chemical engineering  Researcher  2003 - 2005  709 
7.  22770  PhD Blanka Premrov Bajuk  Veterinarian medicine  Researcher  2002 - 2005  40 
8.  00779  PhD Aleš Štrancar  Chemical engineering  Researcher  2003 - 2005  479 
9.  12682  PhD Irena Zdovc  Veterinarian medicine  Researcher  2002 - 2005  464 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,689 
2.  1655  Sartorius BIA Separations L.t.d., Separations technology company  Ajdovščina  1319612  1,189 
Abstract
The incidence of dermatophytosis in man and animals is still increasing in Slovenia as well as in Europe. Treatment of the patients therefore represents a substantial financial problem. In the studies of experimental infections different vaccines were taken under consideration, however neither humoral nor cellular immune response, induced by these experimental vaccines had a satisfactory protective effect against challenge exposure. In our previous studies we have identified some proteinases and protein proteinase inhibitors significant for dermatophyte fungi. In the submitted project we plan to isolate and characterise these proteins and their potential role in the infection and activation of the immune response. On the basis of these results, the potential protective value of these proteins could be estimated.
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