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Projects / Programmes source: ARIS

Organic Chemistry: Synthesis, Structure, and Application

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Periods
January 1, 2004 - December 31, 2008
Research activity

Code Science Field Subfield
1.04.00  Natural sciences and mathematics  Chemistry   

Code Science Field
P390  Natural sciences and mathematics  Organic chemistry 
Keywords
green chemistry, catalysis, stereo- and regioselective synthesis, high-pressure chemistry, cycloadditions, heterocycles, amino acid derivatives, spiro compounds, boron compounds, diazenes, triazenes, electrophilic amination, antibacterials, cytostatics, molecular probes, amyloid aggregates, Alzheimer disease, Creutzfeld-Jacob disease.
Evaluation (rules)
source: COBISS
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (13)
no. Code Name and surname Research area Role Period No. of publications
1.  21343  PhD Sergeja Bombek  Natural sciences and mathematics  Junior researcher  2004 - 2005  31 
2.  26543  PhD Bojan Burja  Natural sciences and mathematics  Junior researcher  2006 - 2008  20 
3.  28338  PhD Jure Hren  Natural sciences and mathematics  Junior researcher  2007 - 2008  23 
4.  17138  Zdenka Kadunc    Technical associate  2004 - 2008  2 
5.  03904  PhD Marijan Kočevar  Natural sciences and mathematics  Head  2004 - 2008  573 
6.  13822  PhD Janez Košmrlj  Natural sciences and mathematics  Researcher  2004 - 2008  505 
7.  20063  PhD Krištof Kranjc  Natural sciences and mathematics  Researcher  2004 - 2008  255 
8.  05044  PhD Andrej Petrič  Natural sciences and mathematics  Researcher  2004 - 2008  206 
9.  02310  PhD Slovenko Polanc  Natural sciences and mathematics  Researcher  2004 - 2008  549 
10.  19527  Irena Povalej    Technical associate  2004 - 2008  1 
11.  19405  PhD Franc Požgan  Natural sciences and mathematics  Researcher  2004 - 2008  371 
12.  18423  PhD Bogdan Štefane  Natural sciences and mathematics  Researcher  2004 - 2008  390 
13.  02314  PhD Bojan Verček  Natural sciences and mathematics  Researcher  2004 - 2008  149 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  22,621 
Abstract
We will be developing novel multidisciplinary methods for the regio- and/or stereoselective synthesis and transformations of organic substrates. Novel biologically active compounds, containing amino acid, diazene and other fragments in the molecule are expected to be prepared. Among other, we plan the synthesis and characterization of novel molecular probes for the in vitro and in vivo assay of amyloid aggregates in the brain tissue of patients with Alzheimer or Creutzfeldt-Jacob disease. In our investigations we will use some basic methods of the research work in chemistry and develop some special techniques for the organic synthesis (high pressure transformations at up to 18 kbar, microwave assisted synthesis, the application of ionic liquids, etc.). Our goal will be to approach to the field of eco-friendly "green chemistry" (solvent-free reactions or using water as a solvent, oxidations preferably with oxygen and peroxides, catalytic reactions, etc.).
Significance for science
The finished project has contributed new knowledge in most important fields of chemistry, namely, organic synthesis, medicinal chemistry and catalysis. The new types of building blocks were prepared and novel techniques for the synthesis, including heterogeneous catalysis, were developed. On the other side, novel reactions in organic synthesis were clarified, and novel types of biologically active compounds were obtained. Additionally, novel aspects of green chemistry were developed aiming at the protection of our environment. The research work on the synthesis, characterization, and application of new molecular probes for medical research rezulted in a new tool for medical research and diagnostics, which will shed light to basic processes, leading to neurological diseases.
Significance for the country
New knowledge is very important for Slovenia in order to protect our environment and in order to help our industry to get acquainted with the progress in the basic research work and also in the development of green applications for industrial purposes. In particular, this knowledge, which is in Slovenia still at rather low or intermediate level, will be improved and brought to Slovenian companies. Namely, students that are going to participate in the research will probably find their positions in the pharmaceutical and also other companies, where such knowledge is more and more indispensable. Our broad connections with the research teams from all over the world will enable us to develop multidisciplinary knowledge and methods to educate our students and younger researchers via international grants in close contacts with the best research teams in the world. The invitations for plenary and other lectures at important international conferences, universities and institutes are very important for the promotion of Slovenian science. Similarly, we promote Slovenia with improving quality of Acta Chimica Slovenica as the best Slovenian internationally recognized journal and by the membership in the Management Committees (COST), IUPAC Committee, editorial board of journals, etc. Our research work is tightly embedded within the existing institutional and especially within national or international research and development programmes and projects. We strictly follow priorities of the Slovenian and international research by developing new materials, novel industrial procedures or their optimizations via contracts with industry and by developing new tools. An example of the latter is the continuous collaboration on the development of a new neuroimaging probe for medical research and diagnostics. The chemical syntheses and characterization are performed at the Faculty of Chemistry and Chemical technology at the University of Ljubljana. Radiosynthesis, in vitro, and in vivo characterization of new probes are performed at the Department of Medical and Molecular Pharmacology at the University of California at Los Angeles. The application of the probe to other neurodegenerative diseases is investigated by colleagues from the Faculty of Medicine at the University of Ljubljana. Since we are a group with a broad expertise of knowledge, we are developing highly interdisciplinary methods that may find in the future broad application in our industrial companies. A part of our research programmes is tightly connected with industrial needs, for example developing industrially relevant reactions (green catalytic hydrogenation or oxidation, etc.).
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