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Projects / Programmes source: ARIS

Systemic autoimmune diseases

Periods
Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
B500  Biomedical sciences  Immunology, serology, transplantation 
Keywords
Antiphospholipid syndrom, antiphospholipid antibodies, Sjoegren's syndrome, ultrasound of salivary glands, disfunction of parasimphathetic system, systemic sclerosis, arterial hypertension
Evaluation (rules)
source: COBISS
Researchers (21)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  02537  PhD Rok Accetto  Cardiovascular system  Researcher  2004 - 2008  277 
2.  19209  PhD Aleš Ambrožič  Microbiology and immunology  Researcher  2004 - 2008  218 
3.  00781  PhD Borut Božič  Microbiology and immunology  Researcher  2004 - 2008  600 
4.  16362  PhD Saša Čučnik  Pharmacy  Researcher  2005 - 2008  385 
5.  09069  PhD Jurij Dobovišek  Cardiovascular system  Researcher  2004 - 2008  132 
6.  28513  Mojca Frank  Microbiology and immunology  Junior researcher  2007 - 2008  142 
7.  21361  PhD Nataša Gašperšič  Microbiology and immunology  Junior researcher  2004 - 2008  76 
8.  22344  PhD Alojzija Hočevar  Microbiology and immunology  Technical associate  2004 - 2008  394 
9.  24471  PhD Špela Irman  Pharmacy  Junior researcher  2007 - 2008  22 
10.  02066  PhD Tatjana Kveder  Microbiology and immunology  Researcher  2004 - 2008  275 
11.  28845  PhD Katja Lakota  Microbiology and immunology  Technical associate  2007 - 2008  233 
12.  10080  PhD Dušan Logar  Microbiology and immunology  Researcher  2005 - 2008  128 
13.  24207  Miroslava Oblak    Technical associate  2005 - 2008 
14.  13602  PhD Sonja Praprotnik  Microbiology and immunology  Researcher  2004 - 2008  371 
15.  07180  PhD Blaž Rozman  Microbiology and immunology  Head  2004 - 2008  563 
16.  26481  PhD Snežna Sodin Šemrl  Microbiology and immunology  Researcher  2006 - 2008  319 
17.  21943  Tinka Švec    Technical associate  2004 - 2008  19 
18.  13601  PhD Matija Tomšič  Microbiology and immunology  Researcher  2004 - 2008  764 
19.  24209  Valentina Zavrl    Technical associate  2005 - 2008 
20.  24208  Marta Zorko  Microbiology and immunology  Technical associate  2005 - 2008 
21.  24206  PhD Polona Žigon  Microbiology and immunology  Technical associate  2005 - 2008  164 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,699 
Abstract
The field of immunology is one of the most rapidly growing areas of scientific experimental and clinical research. Foundations of immunology lay in molecular biology, biochemistry, biophysical chemistry, molecular biotechnology, molecular genetics and clinical medicine. In many countries, including Slovenia, rheumatology covers systemic autoimmune diseases. We have been involved in these studies for more than 15 years. Our recent program deals with three diseases in which the disturbances in humoral immunity play at least a very important if not a crucial role in the pathogenesis of the diseases. The program integrates a/clinical and laboratory research of antiphospholipid syndrome and antiphospholipid antibodies, b/clinical studies of Sjoegren's syndrome with special emphasise on salivary glands together with the detection of antibodies against sinthetic peptides of muscarinic acethylcholine receptors, c/the epidemiological study of arterial hypertension in systemic sclerosis with the studies of functional characteristics of small and middle size artery walls.
Significance for science
Autoimmunity, inflammation, atherosclerosis and thrombosis, are of high priority in the developed countries. The pathogenesis of each of them has been extensively studied in the last two decades. They are frequently associated with systemic autoimmune diseases mainly managed by rheumatologists. However, the interrelations of these processes are still insufficiently understood. Research results contributed to the understanding of the association of studied diseases and represent the basis for future research.
Significance for the country
The role of the program concerning Slovenia’s socio-economic importance include: - the development of the discipline (rheumatology and internal medicine); - the improvement of the technical level of research (introducing or using new techniques available elsewhere in Slovenia and worldwide); - the improvement of diagnostic methods for autoimmune diseases; - the education of specific knowledge in autoimmunity; - the overall improvement of health status and quality of life in Slovenia.
Most important scientific results Final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Final report, complete report on dLib.si
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