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Projects / Programmes source: ARIS

Systemic Autoimmune diseases

Periods
Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
Keywords
Systemic autoimmune diseases, inflammatory rheumatic diseases, optimization of therapy, biologics, comprehensive treatment of patients, precision and personalized medicine, systemic vasculitis, inflammatory arthritis, systemic sclerosis, fibrosis, multiple sclerosis, Sjogren,s syndrome
Evaluation (rules)
source: COBISS
Points
9,858.42
A''
1,706.85
A'
4,589.2
A1/2
6,609.07
CI10
30,809
CImax
6,444
h10
67
A1
34.89
A3
4.5
Data for the last 5 years (citations for the last 10 years) on February 21, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender , archive )
Database Linked records Citations Pure citations Average pure citations
WoS  1,098  34,345  32,839  29.91 
Scopus  883  44,342  42,733  48.4 
Researchers (51)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  02537  PhD Rok Accetto  Cardiovascular system  Retired researcher  2022 - 2024  277 
2.  19209  PhD Aleš Ambrožič  Microbiology and immunology  Researcher  2022 - 2024  218 
3.  39910  Anita Antonič Zakojč    Technical associate  2022 - 2024 
4.  54653  Matija Bajželj  Microbiology and immunology  Junior researcher  2022 - 2024  14 
5.  00781  PhD Borut Božič  Microbiology and immunology  Researcher  2022 - 2024  600 
6.  34774  PhD Gregor Brecl Jakob  Neurobiology  Researcher  2022 - 2024  69 
7.  52564  PhD Neža Brezovec  Microbiology and immunology  Researcher  2022 - 2024  19 
8.  12153  PhD Jana Brguljan-Hitij  Cardiovascular system  Researcher  2022 - 2024  325 
9.  51203  Blaž Burja  Medical sciences  Technical associate  2022  45 
10.  16362  PhD Saša Čučnik  Pharmacy  Researcher  2022 - 2024  385 
11.  21361  PhD Nataša Gašperšič  Microbiology and immunology  Researcher  2022 - 2024  76 
12.  56617  Petra Hadžidaova  Microbiology and immunology  Technical associate  2023 - 2024 
13.  22344  PhD Alojzija Hočevar  Microbiology and immunology  Researcher  2022 - 2024  394 
14.  53817  PhD Laura Iacolina  Biology  Researcher  2022  87 
15.  10693  PhD Jan Kobal  Neurobiology  Researcher  2022 - 2024  144 
16.  57864  PhD Stanislav Kolenčik  Biology  Researcher  2023 - 2024  16 
17.  39911  Sergeja Košir Jošt    Technical associate  2022 - 2024 
18.  57785  Jelka Kramarič  Microbiology and immunology  Researcher  2023 - 2024 
19.  39765  Monika Krošel  Microbiology and immunology  Technical associate  2022 - 2024  22 
20.  02066  PhD Tatjana Kveder  Microbiology and immunology  Retired researcher  2022 - 2024  275 
21.  28845  PhD Katja Lakota  Microbiology and immunology  Head  2022 - 2024  233 
22.  10080  PhD Dušan Logar  Microbiology and immunology  Retired researcher  2022 - 2024  128 
23.  19763  PhD Aleša Lotrič Dolinar  Economics  Researcher  2022 - 2024  79 
24.  57914  Sanja Markez  Microbiology and immunology  Researcher  2023 - 2024 
25.  34804  Katjuša Mrak Poljšak    Technical associate  2022 - 2024  66 
26.  24207  Miroslava Oblak    Technical associate  2022 - 2024 
27.  38271  PhD Manca Ogrič  Microbiology and immunology  Researcher  2022 - 2024  42 
28.  32693  PhD Jasna Omersel  Pharmacy  Researcher  2022 - 2024  89 
29.  39694  Jaka Ostrovršnik  Microbiology and immunology  Technical associate  2022 - 2024  33 
30.  29467  PhD Katja Perdan Pirkmajer  Microbiology and immunology  Researcher  2022 - 2024  154 
31.  56926  Dragica Petric    Technical associate  2023 - 2024 
32.  16184  PhD Martina Plešivčnik Novljan  Microbiology and immunology  Researcher  2022 - 2024  51 
33.  21779  PhD Eva Podovšovnik  Social sciences  Researcher  2022 - 2024  208 
34.  55139  Andreja Poljak    Technical associate  2022 
35.  52613  Sandra Potušek    Technical associate  2022  50 
36.  13602  PhD Sonja Praprotnik  Microbiology and immunology  Researcher  2022 - 2024  371 
37.  15441  PhD Uroš Rot  Neurobiology  Researcher  2022 - 2024  180 
38.  30545  PhD Žiga Rotar  Microbiology and immunology  Researcher  2022 - 2024  308 
39.  07180  PhD Blaž Rozman  Microbiology and immunology  Retired researcher  2022 - 2024  563 
40.  12541  PhD Barbara Salobir  Microbiology and immunology  Researcher  2022 - 2024  256 
41.  26481  PhD Snežna Sodin Šemrl  Microbiology and immunology  Head  2022  319 
42.  57036  Anja Srpčič  Microbiology and immunology  Junior researcher  2022 - 2024  14 
43.  51881  Ula Štok  Microbiology and immunology  Junior researcher  2022  16 
44.  57024  Neža Štucin  Medical sciences  Junior researcher  2022 - 2024 
45.  21943  Tinka Švec    Technical associate  2022 - 2024  19 
46.  06661  PhD Marjeta Terčelj Zorman  Microbiology and immunology  Researcher  2022 - 2024  413 
47.  13601  PhD Matija Tomšič  Microbiology and immunology  Retired researcher  2022 - 2024  764 
48.  34584  PhD Felicita Urzi  Biochemistry and molecular biology  Technical associate  2022 - 2024  89 
49.  11647  PhD Marjan Zaletel  Neurobiology  Researcher  2022 - 2024  716 
50.  24209  Valentina Zavrl    Technical associate  2022 - 2024 
51.  24206  PhD Polona Žigon  Microbiology and immunology  Researcher  2022 - 2024  164 
Organisations (5)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,282 
2.  0355  Orthopaedic Hospital Valdoltra  Ankaran  5053765  2,325 
3.  0584  University of Ljubljana, School of Economics and Business (SEB)  Ljubljana  1626922  42,518 
4.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,522 
5.  2790  University of Primorska, Faculty of mathematics, Natural Sciences and Information Technologies  Koper  1810014009  17,497 
Abstract
Our research program P3-0314 encompasses rheumatologists, pulmonologists, neurologists, gastroenterologists, biochemists, pharmacists, molecular/cell biologists, biostaticians/bioinformaticians, laboratory experts, economists and patients groups. Activities are predominantly geared towards optimization of therapy/drug repurposing, elucidation of disease mechanism for inflammatory rheumatic disease (IRD), novel therapeutic targets and utilization of autoantibodies/biomarkers for earlier diagnostics/prognostics, disease activity and organ involvement. We will introduce comprehensive treatment for patients with IRD, with the aim of achieving lifestyle improvement and developing an effective, financially sustainable model. We will gain detailed insight into pharmacokinetics of biologics in a real clinical setting, helping physicians make better treatment decisions, with a personalized/cost-effective approach. Using precision medicine, we will deepen our understanding of fibrotic mechanisms targeting metabolism, that could lead to new/better therapeutic strategies in systemic sclerosis. Research on anti-SAA1 antibodies could contribute to an innovative approach in treating hyperinflammation that can occur in COVID-19, as well as other diseases (e.g. macrophage activation syndrome, catastrophic antiphospholipid syndrome, septic shock). Systemic vasculitis usually presents as an emergency in rheumatology due to multi-organ involvement/risk of vital organ failure. We will integrate extensive data from multidimensional technologies with high resolution e.g. single-cell RNA sequencing, high-dimensional flow cytometry, ATAC sequencing, epiMethylTag analysis, curated molecular/cellular/clinical data, to build knowledge-based prediction models using machine learning algoritms/artificial inteligence. This will enable identification of most vulnerable patients at earlier time points. We will collaborate in developing (with Institute Jozef Stefan and University of Ljubljana-Faculty of Electrical Engineering) a biomimetic approach to higher quality materials/applications for patient implants. From an economic point of view, we will explore the dilemma of including the cost of productivity losses in the economic evaluation of health technologies for patients with IRD. With the improvements of biorx.si (a tool for capturing high quality data in clinical practice) we will obtain more complete, higher-quality, richer data, without a major burden to rheumatologists. The new, original biorx.si design will allow faster adaptations to new challenges. Our program, P3-0314 (2022-2027) will strive for lowering the substantial personal, social and healthcare burdens of systemic autoimmune diseases, including IRD, while providing the highest possible quality of care and standards to our patients.
Significance for science
Systemic autoimmune diseases, including inflammatory rheumatic diseases (IRD) cover ?80 chronic conditions, with around 20 million cases in Europe and an increasing prevalence. Patients can be exposed to persistent pain, reduced ability to work, loss of organ function, disability and early mortality. Therefore, research in this area is one of the continuous medical priorities. Nevertheless, scientific fields studying systemic autoimmune diseases and IRD are still insufficiently connected and underexplored. Our national research program P3-0314 will continue investigating IRD and other systemic autoimmune diseases with a strong emphasis on 4P medicine (preventive, predictive, personalized and participatory) with a precision approach, bioinformatics tools, registries, and databases. We will bring together clinical sciences, molecular and cell biology, biochemistry, pharmacy, chemistry, physics, electrical engineering, economics, biostatistics, machine learning and artificial intelligence, in order to acquire new knowledge. High dimensional flow cytometry, single cell RNA sequencing, ATAC sequencing and epiMethylTAG analyses will provide high resolution data that will enable, together with highly specialized knowledge from companies, such as BIA Separations/Sartorius (monolithic chromatography) and Nanoview Biosciences (Exoview technology for exosomal markers), the development of new state-of-the-art models/systems such as: a) predictive response model to inflammatory arthritis treatment based on the integration of clinical, imaging, high-dimensional laboratory, cellular and molecular data. b) an efficient and financially sustainable model of integrated comprehensive treatment of IRD patients c) verification of the usefulness of monitoring biologics and their autoantibodies in the newly developed subcutaneous formulation/application of infliximab and vedolizumab d) use of natural anti-SAA1 autoantibodies to silence the cytokine storm e) an innovative approach to modify currently used stent materials f) a new original design of the national, multicenter biorx.si registry, which contributes data along with other international groups (from Finland, Norway, Denmark, Netherlands, Spain, Czech Republic and Russia) evaluating the effectiveness of treatment strategies for rheumatoid arthritis (CERRERA, TOCERRA, JAK-pot) and spondyloarthritis (EuroSpA) Thus, we plan, during 2022-2027, to continue publishing in highly cited, quality scientific journals, such as Annals of The Rheumatic Diseases, Nature Communications, The Lancet, European Heart Journal, Autoimmunity Reviews, Journal of Autoimmunity, Rheumatology, as well as implement the results of P3-0314 into clinical and laboratory practice.
Significance for the country
The national research program P3-0314 has the main and overall aim of improving health and care of patients with systemic autoimmune diseases. The program is important for the development of medical sciences (rheumatology, immunology, internal medicine), technical levels and for the education of young clinical and scientific experts in the field of autoimmunity in Slovenia. P3-0314 includes physicians, nurses, laboratory professionals, technical staff, and researchers, and closely connects the clinic and routine diagnostic laboratory with research aimed at developing improvements and innovation. As a whole, the program contributes to and exhibits priorities in the following aspects important for the socio-economic development of Slovenia: 1. multidisciplinary approach. P3-0314 collaborates with multiple clinical and research centers in SI, EU and USA, with expertise/technologies that accelerate development, integration, transfer of knowledge and research innovation. Our priorities will be patent and project applications at the Slovene, European and US levels, such as terciary projects UMCL, ARRS projects, ERC, MC, ESF, Eureka Eustars, Bill Gates Foundation. Cooperation will strengthen our collaborations with Slovenian Universities and hospitals, namely UP-FAMNIT, UL-FFA, UL-EF and OB Valdoltro, with whom we have had long-term collaborations, as well as our industry partner BIA Separations/Sartorius and with patient organizations, such as the Slovenian Association of Rheumatic Patients and the Slovenian Association of Healthcare Professionals in Rheumatology. 2. education. For P3-0314 education is key for continuous knowledge transfer, both vertically and horizontally. We educate a) doctoral students, master's and undergraduate students through mentoring and lectures, as well as b) professional staff, through workshops, conferences, online lectures, including transferable knowledge. 3. co-organization of congresses/organization of workshops. Members of P3-0314 will co-organize the International Congress on Autoimmunity and organize annual 1-day workshops aimed at presenting the most innovative work of the previous year within the participating groups of P3-0314. 4. application of knowledge. Continual transfer of knowledge is conducted from P3-0314 to the Laboratory of immunology, for measurement of (among others) SAA, aPS/PT, anti-SAA1/2, anti-SAA1, biologics (e.g. adalimumab, infliximab) and their autoantibodies, anti-SARS-CoV-2, anti-IFN?, anti-IL-6. 5. writing manuals, professional instructions and recommendations for doctors and patients. Clinical members of P3-0314 are providing, in Slovenia and within the EU (EU-MUSC Standards of care) professional manuals for clinicians as well as recommendations for patients. 6. activities in working, task force, groups. P3-0314 members are active in working groups e.g. EMEUNET ("working group of young clinicians and researchers in rheumatology"), which is part of the European League against rheumatism (EULAR) and EUSTAR (multicenter, international consortium on Systemic sclerosis). 7. communication with the public, in form of radio/TV events, invited lectures, professional and scientific contributions and popular articles.
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