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Projects / Programmes source: ARIS

Systemic autoimmune diseases

Periods
Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
B500  Biomedical sciences  Immunology, serology, transplantation 

Code Science Field
3.05  Medical and Health Sciences  Other medical sciences 
Keywords
Antiphospholipid syndrom, antiphospholipid antibodies, Sjoegren's syndrome, ultrasound of salivary glands, disfunction of parasimphathetic system, systemic sclerosis, arterial hypertension
Evaluation (rules)
source: COBISS
Researchers (35)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  02537  PhD Rok Accetto  Cardiovascular system  Researcher  2009 - 2014  277 
2.  19209  PhD Aleš Ambrožič  Microbiology and immunology  Researcher  2009 - 2014  218 
3.  32183  PhD Andrej Artenjak  Microbiology and immunology  Researcher  2009 - 2014  22 
4.  00781  PhD Borut Božič  Microbiology and immunology  Researcher  2009 - 2014  600 
5.  16362  PhD Saša Čučnik  Pharmacy  Researcher  2009 - 2014  385 
6.  28513  Mojca Frank  Microbiology and immunology  Junior researcher  2009 - 2010  142 
7.  21361  PhD Nataša Gašperšič  Microbiology and immunology  Researcher  2009 - 2014  76 
8.  22344  PhD Alojzija Hočevar  Microbiology and immunology  Technical associate  2009 - 2014  394 
9.  34803  Maša Huzjak    Technical associate  2011 - 2014 
10.  24471  PhD Špela Irman  Pharmacy  Junior researcher  2009 - 2010  22 
11.  10693  PhD Jan Kobal  Neurobiology  Technical associate  2009 - 2014  144 
12.  02066  PhD Tatjana Kveder  Microbiology and immunology  Researcher  2009 - 2014  275 
13.  28845  PhD Katja Lakota  Microbiology and immunology  Technical associate  2009 - 2014  233 
14.  02087  MSc Boris Lestan  Microbiology and immunology  Technical associate  2014  69 
15.  10080  PhD Dušan Logar  Microbiology and immunology  Researcher  2009 - 2014  128 
16.  34804  Katjuša Mrak Poljšak    Technical associate  2011 - 2014  66 
17.  24207  Miroslava Oblak    Technical associate  2014 
18.  34802  Milena Pavić Nikolić    Technical associate  2011 - 2014  39 
19.  29467  PhD Katja Perdan Pirkmajer  Microbiology and immunology  Researcher  2013 - 2014  154 
20.  16184  PhD Martina Plešivčnik Novljan  Microbiology and immunology  Technical associate  2009 - 2014  51 
21.  13602  PhD Sonja Praprotnik  Microbiology and immunology  Researcher  2009 - 2014  371 
22.  30545  PhD Žiga Rotar  Microbiology and immunology  Technical associate  2009 - 2014  308 
23.  07180  PhD Blaž Rozman  Microbiology and immunology  Researcher  2009 - 2014  563 
24.  12541  PhD Barbara Salobir  Microbiology and immunology  Researcher  2009 - 2014  256 
25.  26481  PhD Snežna Sodin Šemrl  Microbiology and immunology  Head  2009 - 2014  319 
26.  10645  MSc Alenka Šipek Dolničar  Microbiology and immunology  Technical associate  2009 - 2014  37 
27.  29977  Daša Šuput Skvarča  Microbiology and immunology  Technical associate  2009 - 2012  18 
28.  21943  Tinka Švec    Technical associate  2009 - 2014  19 
29.  06661  PhD Marjeta Terčelj Zorman  Microbiology and immunology  Researcher  2009 - 2014  413 
30.  13601  PhD Matija Tomšič  Microbiology and immunology  Researcher  2009 - 2014  764 
31.  11647  PhD Marjan Zaletel  Neurobiology  Researcher  2009 - 2014  716 
32.  24209  Valentina Zavrl    Technical associate  2009 - 2014 
33.  24208  Marta Zorko  Microbiology and immunology  Technical associate  2013 - 2014 
34.  29595  PhD Urška Žager  Pharmacy  Junior researcher  2009 - 2010  19 
35.  24206  PhD Polona Žigon  Microbiology and immunology  Technical associate  2009 - 2014  164 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,666 
Abstract
The field of immunology is one of the most rapidly growing areas of scientific experimental and clinical research. Foundations of immunology lay in molecular biology, biochemistry, biophysical chemistry, molecular biotechnology, molecular genetics and clinical medicine. In many countries, including Slovenia, rheumatology covers systemic autoimmune diseases. We have been involved in these studies for more than 15 years. Our recent program deals with three diseases in which the disturbances in humoral immunity play at least a very important if not a crucial role in the pathogenesis of the diseases. The program integrates a/clinical and laboratory research of antiphospholipid syndrome and antiphospholipid antibodies, b/clinical studies of Sjoegren's syndrome with special emphasise on salivary glands together with the detection of antibodies against sinthetic peptides of muscarinic acethylcholine receptors, c/the epidemiological study of arterial hypertension in systemic sclerosis with the studies of functional characteristics of small and middle size artery walls.
Significance for science
The research group is studying systemic autoimmune diseases. Since patients with systemic autoimmune diseases are also prone to early development of cardiovascular diseases, such as atherosclerosis, the following research fields are studied: 1. The broad field of thromboses in autoimmune systemic diseases 2. Diseases of the vasculature 3. Autoimmunity and autoimmune antibodies as diagnostic and prognostic tools (epitope and avidity studies and development/optimization of methodologies) 4. Inflammation, using serum amyloid A as an acute phase protein and a marker of inflammation in systemic autoimmune diseases with an inflammatory component, especially where C-reactive protein does not work well to indicate inflammation. The research group uses, among other methods, molecular, cellular technologies, quantitative PCR, atomic force microscopy, surface plasmon resonance, as well as performs cross-sectional and longitudinal studies. Research is being conducted at the basic and translational (research laboratory), routine (diagnostic laboratory) and clinical levels within the Department of Rheumatology, UKC-Lj, as well as between departments in UMC-Lj (Neurology, Pulmology, Hypertension), and with international collaborations to achieve the main goal of optimizing prediction, prevention and personalized care of patients.
Significance for the country
The research group has the main intent of achieving better patient health and care. The results of the research programme are important for Slovenia from the the following points of view: 1. Using optimization in our diagnostic, routine laboratory (e.g. antiphospholipid antibodies, anti-prothrombin antibodies and serm amyloid A (SAA) as an inflammatory marker). The diagnosis and prognosis are based on standard markers, among them autoantibodies and inflammatory markers, such as SAA and CRP, which play important roles. 2. Transfer of knowledge derived from research into clinical practice, such as the patent for the detection of anti-dsDNA autoantibodies as an improved, novel routine laboratory test, for the direct benefit of the patient. 3. We organized and hosted the 7th Autoimmunity International Congress with more than 1600 participants. 4. We developed the electronic Registrar of patients with inflammatory rheumatic diseases, who are taking biological drugs, in order to improve their safety. 5. We organized and hosted a 3-day international, multicenter workshop on Serum Amyloid A, the measurements of which were introduced into routine practice. 6. Involvement in many international research projects. 7. Leading and coordinating an international multicenter consortium on serum amyloid A, as an important marker of inflammation. 8. We were mentors of many undergraduate/masters and doctoral students.
Audiovisual sources (1)
no. Title (with video link) Event Source
1. Systemic autoimmune diseases    Research programme video presentation 
Most important scientific results Annual report 2009, 2010, 2011, 2012, 2013, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, 2012, 2013, final report, complete report on dLib.si
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