Projects / Programmes source: ARIS

Investigation of Compounds from Natural Sources by Modern Chromatographic and Spectroscopic Techniques

Research activity

Code Science Field Subfield
1.04.00  Natural sciences and mathematics  Chemistry   

Code Science Field
P300  Natural sciences and mathematics  Analytical chemistry 
flavonoids, phenolic acids, vitamins, carotenoids, naphtoquinones, enzymes, plant materials, nutrition, medicines, cosmetics, structure elucidation, chromatography, mass spectometry, NMR
Evaluation (rules)
source: COBISS
Researchers (13)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  18671  PhD Samo Andrenšek  Chemistry  Researcher  2004  151 
2.  12667  PhD Miloš Barut  Chemistry  Researcher  2004 - 2007  206 
3.  24077  PhD Peter Brne  Chemistry  Researcher  2004 - 2007  28 
4.  07493  MSc Nataša Ferant  Biology  Researcher  2005 - 2007  285 
5.  20830  MSc Nadja Gerčar  Chemistry  Researcher  2004  20 
6.  23053  PhD Maja Milivojević Fir  Chemistry  Junior researcher  2004 - 2007  46 
7.  10082  PhD Janez Plavec  Chemistry  Researcher  2004 - 2007  1,230 
8.  01095  PhD Mirko Prošek  Chemistry  Researcher  2004 - 2007  406 
9.  17266  Mateja Puklavec    Technical associate  2004 - 2007  22 
10.  10039  PhD Janko Rode  Plant production  Researcher  2004  545 
11.  15461  PhD Breda Simonovska  Plant production  Head  2004 - 2007  246 
12.  00779  PhD Aleš Štrancar  Chemical engineering  Researcher  2004 - 2007  479 
13.  11395  PhD Irena Vovk  Chemistry  Researcher  2004 - 2007  558 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,357 
2.  0416  Slovenian Institute of Hop Research and Brewing  Žalec  5051762000  4,125 
3.  1655  Sartorius BIA Separations L.t.d., Separations technology company  Ajdovščina  1319612  1,179 
We propose investigation of biologically active natural compounds with potentially beneficial influence on human health. The starting material will be of plant origin. We will search for the best extraction conditions, develop methods of extract purification, perform different chromatographic separations and study chemical features of chosen compounds. For the identification of compounds we will use the combination of modern spectroscopic techniques (nuclear magnetic resonance; mass spectrometry as detector in high-performance liquid chromatography etc.) and develop new chromoatographic methods where needed. The developed analytical methods (for flavonoids, phenolic acids, vitamins, carotenoids etc.) will be used also for analyzing food supplements (in fact concentrated micronutrients) appearing on the market at accelerated rate, and also ordinary food od plant origin, exposed to different coditions, for comparison. Part of the studied compounds will be isolated and/or prepared for the transformation into products, which will improve the material sight of human life as the final goal (food, medicines, cosmetics). Investigations in this field are often the matter of patent protection, therefore gaining know-how, unaccesible in the literature, needs a lot of experimental work. Using modern chromatographic techniques (with emphasis on new applications of porous polymeric monolithic chromatographic stationary phases and application of mass spectrometry for detection and identification of compounds) we will achieve the final goals of the proposed project which is profound investigation of a few groups of natural compounds (polyphenols, carotenoids) in chosen plant materials. A special attention we will pay to natural naphtoquinones, synthesized in roots by some plants from the Boraginaceae family. These compounds have besides interesting purple coloration and coloring capability also exceptionally wide spectrum of biological activities. We will perform the needed botanical experiments with four different plants in order to get plant material grown in controlled conditions. The results obtained (together with those of biological tests) will represent the starting point for the incorporation of the prepared substances into new products in pharmaceutical, cosmetic and food industry and also encouragement for introduction of new crops in rural areas.
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