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Projects / Programmes source: ARIS

Use of inorganic particles for particle design and their potential application in systems with modified release

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Research activity

Code Science Field Subfield
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
T150  Technological sciences  Material technology 
T130  Technological sciences  Production technology 
Keywords
composites, controlled release, amorphicity, modification of physicochemical properties, coating of composites
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (8)
no. Code Name and surname Research area Role Period No. of publications
1.  11517  PhD Marjan Bele  Materials science and technology  Head  2004 - 2007  546 
2.  22658  PhD Mateja Cegnar  Pharmacy  Researcher  2006 - 2007  91 
3.  19785  PhD Bojan Doljak  Pharmacy  Researcher  2004 - 2007  257 
4.  00582  PhD Miran Gaberšček  Materials science and technology  Researcher  2004 - 2007  900 
5.  10180  PhD Janko Jamnik  Materials science and technology  Researcher  2004 - 2007  337 
6.  14935  PhD Odon Planinšek  Pharmacy  Researcher  2004 - 2007  438 
7.  09031  PhD Stanko Srčič  Pharmacy  Researcher  2004 - 2007  675 
8.  19063  PhD Andrijana Tivadar  Pharmacy  Researcher  2004 - 2005  75 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  20,968 
2.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,159 
Abstract
Dissolution of drug substances is one of the biggest challenges in development of pharmaceutical formulations because the dissolution rate decisively affects the absorption and uptake of drugs. In the project, various new drug substance-inorganic substrate composites will be prepared. The specific nanoarchiterctural features of different composites will control the rate of drug dissolution. The new composites will be prepared either using a sol-gel procedure or precipitation from mixtures of solvents. The first research segment will comprise preparation of biocompatible inorganic coatings with controlled thickness, porosity and selected solubility. The final properties of the composites (dissolution rate, compressibility) will also be determined by drug pretreatment (micronization etc.). In the second segment, the drug will be incorporated into inorganic gel structure. The resulting drug amorphization and stabilization will have influence on dissolution rate but also on stability against moisture and oxygen. In the third segment, the substance will be adsorbed, deposited or incorporated (matrix type) onto or into biocompatible inorganic nanoparticles. Due to increased surface area, such a composite structure usually leads to an increase of the dissolution rate and, at the same time, to a mechanically more stable material. In the last segment, drug particles will be designed using a procedure of controlled liquid-solid transition in the presence of specific additives. The procedures are expected to change the size, morphology, surface area and porosity of the resulting particles.
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