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Projects / Programmes source: ARIS

Development of a technological procedure for preparation of biologicaly active hop extract enriched with xanthohumol

Research activity

Code Science Field Subfield
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
T430  Technological sciences  Food and drink technology 
T410  Technological sciences  Pharmaceuticals and related technologies 
Keywords
extraction, technology, ksanthohumol, biological activity, antigenotoxicity
Evaluation (rules)
source: COBISS
Researchers (15)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  19785  PhD Bojan Doljak  Pharmacy  Researcher  2004 - 2006  257 
2.  19157  PhD Tanja Fatur  Public health (occupational safety)  Researcher  2004  313 
3.  09892  PhD Metka Filipič  Biology  Researcher  2004 - 2006  585 
4.  22311  PhD Javor Kac  Pharmacy  Researcher  2004 - 2006  71 
5.  02619  PhD Željko Knez  Chemical engineering  Researcher  2004 - 2006  2,017 
6.  04648  PhD Janko Kos  Biotechnical sciences  Researcher  2005 - 2006  1,154 
7.  21689  PhD Petra Kotnik  Chemical engineering  Researcher  2004 - 2006  155 
8.  07802  PhD Tamara Lah Turnšek  Biology  Head  2004 - 2006  1,018 
9.  18387  PhD Aleš Mlinarič  Pharmacy  Researcher  2004 - 2005  166 
10.  23609  PhD Janja Plazar  Educational studies  Researcher  2004  220 
11.  16193  Nataša Sever  Pharmacy  Technical associate  2004 - 2006  30 
12.  11865  PhD Mojca Škerget  Chemical engineering  Researcher  2004 - 2006  763 
13.  09635  PhD Andrej Umek  Pharmacy  Researcher  2004 - 2006  171 
14.  10974  PhD Irena Zajc  Biochemistry and molecular biology  Researcher  2005 - 2006  134 
15.  20767  PhD Bojana Žegura  Biology  Researcher  2004 - 2006  338 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0105  National Institute of Biology  Ljubljana  5055784  13,305 
2.  0787  University of Ljubljana, Faculty of Pharmacy  Ljubljana  1626973  17,522 
3.  0794  University of Maribor, Faculty of Chemistry and Chemical Engineering  Maribor  5089638012  13,015 
Abstract
Several published studies, have shown that prenylated flavonoids from hops, particularly xanthohumol exhibit cytotoxic and antiproliferative effects against tumour cell lines, exhibit anti-inflammatory effects due to the inhibition of cyclooxigenases 1 and 2 and act as free radical scavengers. The studies conducted at Faculty of Pharmacy, University of Ljubljana and national Institute of Biology showed that xanthohumol exerts antimutagenic activity particularly against carcinogenic heterocyclic amines. These properties indicate that xanthohumol can prevent cancer initiation and development; therefore it can be used as the basis for development of food and pharmaceutical products with elevated content of xanthohumol for cancer prevention. The aim of the proposed project is to develop a technological procedure for preparation of biologicaly active hop extract enriched with xanthohumol, for industrial production. The enriched extract will be standardized to the xanthohumol content and will have assured biologycal activity. There fore we will also develop appropriate analytical methodology for xanthohumol determination. The biological activity will be determined by measuring antimutagenic activity of the extracts against heterocyclic amines. Additional molecular and biological studies of antimutagenic activity of xanthohumola and the extract will be conducted with test systems with human cell lines to elucidate the mechanisms of antimutagenic activity, which will be the basis for assessment of the preventive effectiveness in humans. Biologically active hop extract, enriched with xanthohumol will be commercially used for further development of functional food products (beer, other drinks) and pharmaceutical products with cancer preventive properties.
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