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Projects / Programmes source: ARIS

Time- and position-controlled release of drug substances coated onto superparamagnetic nanoparticles

Research activity

Code Science Field Subfield
2.04.00  Engineering sciences and technologies  Materials science and technology   

Code Science Field
T150  Technological sciences  Material technology 
T130  Technological sciences  Production technology 
Keywords
particle coatings, nanostructured materials, superparamagnetic particles, controlled release of drugs, modification of physical-chemical properties
Evaluation (rules)
source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  11517  PhD Marjan Bele  Materials science and technology  Head  2004 - 2007  542 
2.  15623  PhD Matejka Burjak  Pharmacy  Researcher  2004 - 2007  51 
3.  01360  PhD Mihael Drofenik  Chemistry  Researcher  2004 - 2007  770 
4.  00582  PhD Miran Gaberšček  Materials science and technology  Researcher  2004 - 2007  896 
5.  10180  PhD Janko Jamnik  Materials science and technology  Researcher  2004 - 2007  337 
6.  12942  PhD Janez Kerč  Pharmacy  Researcher  2004 - 2007  240 
7.  10372  PhD Darko Makovec  Materials science and technology  Researcher  2004 - 2007  665 
8.  12634  PhD Mateja Salobir  Chemistry  Researcher  2004 - 2007  38 
9.  18289  PhD Peter Svete  Chemistry  Researcher  2004 - 2007  31 
10.  07475  Silvo Zupančič    Technical associate  2004 - 2005  17 
11.  09178  PhD Janko Žmitek  Pharmacy  Researcher  2004 - 2007  297 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,470 
2.  0106  Jožef Stefan Institute  Ljubljana  5051606000  89,961 
3.  0258  Lek Pharmaceutical Company d.d.  Ljubljana  1732811  8,400 
Abstract
Controlled release of drug substances is a major research issue. In most cases, the goal is to modify the substance properties in order to influence the rate of its dissolution in body. In the present project, we want to make a step further - we want to control not only the dissolution rate but also the position of drug release. The basic idea is to "attach" (adsorb, deposit etc.) the substance onto superparamagnetic nanoparticles which can then be directed to the position of drug release via an external magnetic field. Superparamagnetic nanoparticles are appropriate substrate for preparation of such composite materials because, in the absence of magnetic field, they can be dispersed in certain media which is a precondition for a successful particle functionalization. Superparamagnetic nanoparticles will be coated with a drug substance according to a modified sol-gel procedure similar to that used in functionalization of inorganic particles with organic substances, like organic pigments. The rate of drug dissoluton will be controlled in different ways: by modifying its morphology, crystallinity, porosity. Also controlled will be the thickness of the drug layer which will have an important effect on stability, viscosity and other physical-chemical properties of the dispersion. The rate of drug dissolution/release will be additionally controlled with additional coatings using a third material resulting in an "onion" type of particulate material. A special challenge will represent the fact that the selection of materials used will be highly limited - all will have to be biocompatible and biodegradable.
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