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Projects / Programmes source: ARIS

Functional genomics and biotechnology for health

Periods
Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   
4.06.00  Biotechnical sciences  Biotechnology   
3.04.00  Medical sciences  Oncology   

Code Science Field
B0   Biomedical sciences  B0  
P320  Natural sciences and mathematics  Nucleic acids, protein synthesis 
B220  Biomedical sciences  Genetics, cytogenetics 
B200  Biomedical sciences  Cytology, oncology, cancerology 
T490  Technological sciences  Biotechnology 

Code Science Field
1.06  Natural Sciences  Biological sciences 
Evaluation (rules)
source: COBISS
Researchers (51)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  16104  PhD Apolonija Bedina Zavec  Biotechnology  Researcher  2009 - 2014  152 
2.  21407  PhD Sabina Berne  Biotechnology  Researcher  2009 - 2014  165 
3.  18325  PhD Simon Caserman  Biochemistry and molecular biology  Researcher  2009 - 2014  107 
4.  18622  PhD Nataša Debeljak  Biochemistry and molecular biology  Researcher  2009 - 2014  241 
5.  28559  PhD Urška Dermol  Chemical engineering  Researcher  2009 - 2013  17 
6.  25530  PhD Petra Draškovič  Biochemistry and molecular biology  Junior researcher  2009  59 
7.  18992  PhD Martina Fink  Biochemistry and molecular biology  Researcher  2009 - 2013  124 
8.  20347  PhD Klementina Fon Tacer  Metabolic and hormonal disorders  Researcher  2009 - 2012  126 
9.  06108  PhD Vladimira Gaberc-Porekar  Biotechnology  Researcher  2009 - 2014  220 
10.  18529  Dubravka Germ    Technical associate  2009 - 2014 
11.  22406  PhD Maša Goršič Krisper  Biochemistry and molecular biology  Researcher  2009  21 
12.  32099  PhD Maja Grundner  Biochemistry and molecular biology  Researcher  2009 - 2010  34 
13.  30692  PhD Mateja Hafner  Biochemistry and molecular biology  Researcher  2009 - 2014  25 
14.  26055  PhD Gorazd Hribar  Biochemistry and molecular biology  Researcher  2009 - 2014  49 
15.  21395  PhD Petra Hudler  Medical sciences  Researcher  2009 - 2014  152 
16.  17275  Ana Marija Jesenko    Technical associate  2009 - 2013 
17.  21352  PhD Peter Juvan  Human reproduction  Researcher  2009 - 2014  163 
18.  28916  PhD Damjana Kastelic  Biochemistry and molecular biology  Researcher  2009 - 2014  33 
19.  24562  Helena Klavžar  Biochemistry and molecular biology  Technical associate  2009 - 2014 
20.  29388  PhD Nina Kočevar Britovšek  Natural sciences and mathematics  Researcher  2009 - 2014  36 
21.  06135  PhD Radovan Komel  Biochemistry and molecular biology  Head  2009 - 2014  1,054 
22.  21507  PhD Branka Korošec  Systems and cybernetics  Researcher  2009 - 2013  61 
23.  29321  PhD Rok Košir  Cardiovascular system  Researcher  2009 - 2014  90 
24.  37493  PhD Urša Kovač  Metabolic and hormonal disorders  Junior researcher  2014  25 
25.  00385  PhD Nada Kraševec  Biotechnology  Researcher  2009 - 2014  213 
26.  18847  Marjan Kužnik    Technical associate  2010 - 2014 
27.  23473  PhD Ljerka Lah  Biotechnology  Researcher  2009 - 2013  60 
28.  17276  Jelka Lenarčič    Technical associate  2009 - 2014 
29.  21241  PhD Ana Lenassi Zupan  Biotechnology  Researcher  2009 - 2012  16 
30.  15355  PhD Branimir Leskošek  Public health (occupational safety)  Researcher  2014  182 
31.  14305  PhD Mirjana Liović  Metabolic and hormonal disorders  Researcher  2009 - 2014  147 
32.  33090  PhD Gregor Lorbek  Pharmacy  Junior researcher  2010 - 2014  66 
33.  32116  PhD Metka Novak  Biochemistry and molecular biology  Junior researcher  2009 - 2013  109 
34.  22581  PhD Mateja Novak Štagoj  Biotechnology  Researcher  2009 - 2013  20 
35.  22580  PhD Špela Peternel  Biochemistry and molecular biology  Researcher  2009 - 2012  42 
36.  12048  PhD Marjetka Podobnik  Biochemistry and molecular biology  Researcher  2009 - 2014  316 
37.  28382  PhD Uršula Prosenc Zmrzljak  Public health (occupational safety)  Researcher  2009 - 2014  87 
38.  22459  PhD Tadeja Režen  Neurobiology  Researcher  2009 - 2014  235 
39.  34353  PhD Marija Rogar  Biochemistry and molecular biology  Junior researcher  2011 - 2014  25 
40.  35360  PhD Sandra Ropret  Biochemistry and molecular biology  Junior researcher  2012 - 2014  15 
41.  06013  PhD Damjana Rozman  Biochemistry and molecular biology  Researcher  2009 - 2014  887 
42.  24925  PhD Vanja Smilović  Biotechnology  Technical associate  2009  13 
43.  33735  PhD Neja Šamec  Biochemistry and molecular biology  Technical associate  2011 - 2014  82 
44.  28347  PhD Klemen Španinger  Oncology  Researcher  2009 - 2014  62 
45.  21684  Tea Tomšič    Technical associate  2009 - 2014 
46.  30720  PhD Nina Trošt  Medical sciences  Researcher  2009 - 2014  28 
47.  35357  PhD Žiga Urlep  Interdisciplinary research  Junior researcher  2012 - 2014  53 
48.  36368  PhD Marko Vidak  Medical sciences  Junior researcher  2013 - 2014  22 
49.  27742  PhD Alja Videtič Paska  Medical sciences  Researcher  2009 - 2014  218 
50.  26574  PhD Matjaž Vogelsang  Biochemistry and molecular biology  Researcher  2009 - 2013  41 
51.  33509  Tina Zupančič  Biotechnology  Technical associate  2012 - 2014  25 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  20,916 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,182 
Significance for science
Functional genomics is a post-genome science that looks upon the cell and its biochemical and pathophysiological phenomena as integrated systems. In this way it studies simultaneous and intertwining events and molecular switches in the network of interactions, with the aim to understand the complex biochemical mechanisms of pathologies. These may then be the basis for new diagnostic/therapeutic approaches and to develop new drugs with a more specific targeted action and without side effects. Our research was oriented to the molecular causes of individual pathologies, however at the same time iz opens the way for the search for potential common mechanisms. A large number of recent data indicates that apparently unrelated multifactorial diseases (for example cancer, diabetes, cardiovascular diseases, neurodegenerative diseases, and even psychiatric disorders), share common starting points such as defective metabolism, modified immune or inflammatory response, and disturbances of the circadian rhythm. The remarkable progress in high-throughput analytical methods has had a profound impact on biomedical research. The determined sequences of many genomes, including the human, upgraded molecular biology through functional genomics into systems biology or medicine. The huge amount of data derived from genomics requires a close cooperation between researchers who produce experimental data, and bioinformaticians who analyse and model the data. We are now beginning to understand human diseases as dynamic disturbances of complex and integrated genetic, molecular and cellular rhythmic networks, which are sensory and interactively connected to the environment. The shift from the traditional view on medicine and research, enabled by powerful post-genome technologies, is the fundamental driving force of our research. Through our research we will develop an integrated platform to study complex multifactorial diseases (from genomics, transcriptomics and proteomics to bioinformatical data analysis system) and the design of new diagnostic and therapeutic approaches. The expertise and methodology will be made available to effectively address any complex disease, and possibly may become the starting point for new "spin-off" companies (nano-antibodies, diagnostic tools, therapeutics, bioinformatical analyses). Our scientific findings fall into the category of basic scientific knowledge in the fields of biochemistry, molecular biology, functional genomics and mathematical approaches. Taken together, all this leads to systems medicine, which will have a major impact on public health and economy in the next decade.
Significance for the country
The program P1-0104 was held during three consecutive periods: 1999-2003; 2004-2008; 2009-2014. It connected research groups from the Faculty of Medicine (MF) and the National Institute of Chemistry (NIC) and was listed among the most successful programs in 2004 by ARRS. It introduced molecular diagnostics and genetic analysis into Slovenian medicine and forensics. It also held a long-term cooperation with the pharmaceutical company Lek and had a key role in the founding of the Sandoz Biopharmaceuticals center at Lek. This resulted with the first Slovenian process for biological drug production, which was in the period after 2009 applied to global manufacturing at Sandoz. The program is also the initiator of the Slovenian Network for Functional Genomics that set up a national infrastructure Centre for Functional Genomics and Bio-Chips. Research in the last period (2009-2014) was significantly shifted to the research of complex diseases, with novel approaches and scientific thinking, which would enable novel, comprehensive insights into risk factors, mechanisms of development and progression of complex pathologies. By discovery of new genetic associations and the role of molecular targets the program enables the development of new diagnostic and therapeutic approaches and targeting drugs, and thus also their direct transfer to clinical practice. The improvement of approaches towards rational pharmacotherapy creates the ways for more patient-oriented medicine. New post-genomic thinking has also deep impact in education of medical doctors and scientists at the graduate and doctoral university studies.
Most important scientific results Annual report 2009, 2010, 2011, 2012, 2013, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, 2012, 2013, final report, complete report on dLib.si
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