Loading...
Projects / Programmes source: ARIS

Metabolic and hereditary factors of reproductive health, delivery

Periods
Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   
3.07.00  Medical sciences  Metabolic and hormonal disorders   
2.06.00  Engineering sciences and technologies  Systems and cybernetics   
6.06.00  Humanities  Culturology   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
pregnancy, screening tests, chromosomopathies, teratology, mercury toxicity, thyroid diseases, iodine metabolism, menstrual irregularities, gene candidates for menopausis praecox, preterm delivery, biomedical signals analysis, characterisation of parameters, data mining of temporal lines, classification of time events, prediction of events, quality improvement for the parturient and individualized care, labour and delivery as physiological, cultural and psychological interaction, women's rights, labour and delivery culture, toxoplasmosis
Evaluation (rules)
source: COBISS
Researchers (48)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  05273  PhD Janez Babnik  Human reproduction  Researcher  2009 - 2012  180 
2.  24470  PhD Tina Bregant  Human reproduction  Junior researcher  2009 - 2013  474 
3.  18541  Matjaž Centa    Technical associate  2009 - 2013 
4.  03896  PhD Matko-Vasili Cerar  Human reproduction  Researcher  2009 - 2012  129 
5.  12176  PhD Lilijana Cerar Kornhauser  Human reproduction  Researcher  2013  209 
6.  27931  Radomir Čolič    Technical associate  2009 - 2012 
7.  26066  Zdenka Dolinar    Technical associate  2009 - 2013 
8.  14076  PhD Zalka Drglin  Sociology  Researcher  2009 - 2013  545 
9.  35405  Teja Fabjan  Medical sciences  Junior researcher  2012 - 2013  43 
10.  28073  Vesna Fabjan Vodušek  Human reproduction  Technical associate  2009 - 2013  110 
11.  26513  PhD Gašper Fele Žorž  Computer science and informatics  Junior researcher  2009 - 2010  21 
12.  00814  PhD Ksenija Geršak  Human reproduction  Head  2009 - 2013  522 
13.  07652  PhD Vislava Globevnik Velikonja  Human reproduction  Researcher  2009 - 2013  316 
14.  19208  PhD Barbara Gnidovec Stražišar  Neurobiology  Researcher  2009 - 2013  190 
15.  17635  Klementa Habjan    Technical associate  2009 - 2012 
16.  03438  PhD Franc Jager  Computer science and informatics  Researcher  2009 - 2013  158 
17.  17160  PhD Aleš Jerin  Cardiovascular system  Researcher  2009 - 2013  196 
18.  28896  Nataša Jeršin    Technical associate  2009 - 2013 
19.  27741  PhD Simona Jurković Mlakar  Pharmacy  Junior researcher  2009 - 2010  82 
20.  34719  Simona Kovačič  Human reproduction  Technical associate  2012 - 2013 
21.  17638  Meta Kovačič Lužnik    Technical associate  2009 - 2013 
22.  23230  PhD Ljuba Krnjak  Human reproduction  Researcher  2009 - 2012  65 
23.  34577  Kristina Kumer  Human reproduction  Junior researcher  2011 - 2013  57 
24.  30746  PhD Miha Lučovnik  Human reproduction  Researcher  2012 - 2013  369 
25.  09180  PhD David Neubauer  Oncology  Researcher  2009 - 2013  747 
26.  04216  PhD Živa Novak-Antolič  Human reproduction  Researcher  2009 - 2013  418 
27.  26064  Ljuba Orel    Technical associate  2009 - 2012 
28.  21413  PhD Damjan Osredkar  Human reproduction  Researcher  2009 - 2012  474 
29.  10691  PhD Joško Osredkar  Human reproduction  Researcher  2009 - 2013  1,305 
30.  05325  PhD Darja Paro  Neurobiology  Researcher  2009 - 2013  350 
31.  35640  PhD Lucija Pavše  Human reproduction  Junior researcher  2013  33 
32.  22159  Martina Pečlin    Technical associate  2009 - 2013 
33.  00789  PhD Tanja Premru-Sršen  Human reproduction  Researcher  2009 - 2013  359 
34.  03893  PhD Marija Prezelj  Human reproduction  Researcher  2009 - 2013  218 
35.  17649  Mirjana Puršič    Technical associate  2009 
36.  32180  PhD Barbara Rejc  Pharmacy  Junior researcher  2009 - 2013  11 
37.  28510  PhD Jasmina Živa Rožman  Human reproduction  Researcher  2009 - 2012  44 
38.  17431  Stanislava Sever    Technical associate  2009 - 2013 
39.  11331  PhD Milan Skitek  Oncology  Researcher  2009 - 2013  326 
40.  18199  PhD Aleš Smrdel  Computer science and informatics  Researcher  2009 - 2013  86 
41.  26065  Darja Strnad-Tetičkovič    Technical associate  2009 - 2013 
42.  32182  PhD Staša Stropnik  Neurobiology  Junior researcher  2009 - 2013  19 
43.  15150  PhD Irena Štucin-Gantar  Human reproduction  Researcher  2009 - 2013  103 
44.  17653  Danica Štuhec    Technical associate  2009 - 2013 
45.  28871  PhD Andreja Trojner Bregar  Human reproduction  Technical associate  2009 - 2010  166 
46.  15638  PhD Nataša Tul-Mandić  Human reproduction  Researcher  2009 - 2013  362 
47.  05015  PhD Ivan Verdenik  Human reproduction  Researcher  2009 - 2013  479 
48.  26062  Sabina Zupan    Technical associate  2009 - 2012 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,288 
2.  1539  University of Ljubljana, Faculty of Computer and Information Science  Ljubljana  1627023  15,996 
Abstract
1. Screening tests for chromosomopathies and pregnancy complications. Free beta HCG nd PAPP-A values between 11. and 14. week of gestation in pregnant women with trisomy 21, trisomy 18 or sex chromosomes abberations are different from the values in pregnant women with normal fetuses. The values of these markers can also be different in women where fetal karyotype is normal but complications in pregnancy occur. Screening tests for Slovenia will be validated. Analysis of false positive results, predictive values and appropriateness according to the population characteristics will be performed. 2. Influence of chemical and biochemical factors on reproductive health. Those toxic, subtoxic and biological effects of mercury, connected to lipid peroxidation and oxidative DNA damage will be studied as well as some biological markers. Cumulation of mercury in epiphysis, anterior hypophysis, thyroid gland and testes can potentially influence function of the glands. We will evaluate the effects of mercury retrospectively; in the city of Idrija after 500 years of mercury mine functioning the pollution and exposition are high. 3. The incidence and forms of thyroid dysfunction in reproductive period. We will try to evaluate if the iodine intake in pregnancy in Slovenia is adequate, as this has influences on the fetus and the incidence of thyroid diseases later in life. We want to ascertain the incidence of thyroid diseases in pregnancy and puerperium and etiology of these diseases for our population. 4. Hereditary factors of menstrual irregularities. In patients with menstrual irregularities we will continue with analysing some of the genetical factors (DNA ploidy of granulosa-thecca cells, mutaitions in the GALT gene, variations in the CYP11a gene). 5. Preterm delivery is the most frequent complication in pregnancy, adding most to perinatal morbidity and mortality. With additional analyses of signals of electrohysterograms we will try to improve predictive value for preterm delivery and institute a system with simple and repeatable recording of signals. Psychological stress and labor and delivery as the central life event will be studied. 6. Primary infection with Toxoplasma gondii in pregnancy. Study of congenital toxoplasmosis detection with DNA analysis of amniotic fluid with PCR analysis will be performed.
Significance for science
The programme “Metabolic and Innate Factors of Reproductive Health, Labour II” is based on the need to broaden knowledge and improve the performance in the field of reproductive health with the implementation of basic scientific and clinically applicable research work. In the 5-­year period and based on the set objectives in the 4 work packages the research group has published 87 publications in journals cited by the SCI/SCE with impact factors (IF) ranging from 0.067 to 10.603. There are 19 articles, which have been published in journals ranked A' or A''. The members of the research group were doctoral mentors to 10 candidates, master’s thesis mentors to 10 candidates and involved in 3 specialist’s projects. They were also doctoral co­-mentors to 5 candidates and master’s thesis co­-mentors to 3 candidates. Four Prešeren’s student research projects have also been completed. The results were presented in many international meetings as invited lectures, oral presentations and posters. The researchers participate in various international projects; they are editors of international journals and co-organizers of international meetings. The results have raised many new questions that enable us to actively pursue new objectives to work towards in the coming years.
Significance for the country
Achieved objectives in all 4 work packages have resulted in new knowledge which has already proven to be successful in direct clinical practice and that we have been incorporating into clinical guidelines and clinical pathways. 1 – There are 6­7% of premature labours in Slovenia; however, they contribute to 60% of perinatal mortality and morbidity, which places us in the group of European countries with an averagely high incidence of premature labour. An agreement is in place between the 14 maternity hospitals in Slovenia that a pregnant woman in danger of labour before the 32nd week of gestation is sent to one of the tertiary­ level hospitals in Ljubljana (University Medical Centre Ljubljana) or Maribor (University Medical Centre Maribor). With the development and application of methods to more reliably predict preterm labour we wish to reduce costs, avoid unnecessary side effects of treatment with tocolytics and therapy for foetal maturation with corticosteroids and an unnecessary relocation to a tertiary­ level hospital, thus reducing the risk of neonatal mortality and morbidity. A fact important for Slovenia is that we have properly translated neuropsychological tests into Slovenian language which have already been used in the clinical follow­up of former neonates with perinatal hypoxia and its lifelong effects on the quality of life. 2 – We will improve the quality of perinatal care in Slovenia by analyzing the data from the National Perinatal Information System (NPIS) and incorporate them into the renewed clinical guidelines. 3 – We observed serum levels of cadmium, lead and mercury in the Slovenian population of women living in urban environment that are comparable to those of countries in the Central and Northern Europe. However, the concentrations mentioned above are lower compared to those in Asia. 4 – The results of genetic research in the field of disorders of ovarian function play an important role in everyday clinical practice and present a possibility of direct integration of new diagnostic methods in the treatment of patients. By indentifying polymorphic alleles of genes involved in the metabolism of estrogens we would specify the group of women with an increased risk for breast cancer due to the additional estrogens exposure when on hormone replacement therapy (HRT).
Most important scientific results Annual report 2009, 2010, 2011, 2012, final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Annual report 2009, 2010, 2011, 2012, final report, complete report on dLib.si
Views history
Favourite