Metabolic and hereditary factors of reproductive health-Labour III

Our research programme will consist of 7 work packages (WP): WP1 Electrophysiology of Delivery WP2 Antenatal Health Care (2 Subpackages) WP2.1 Fetal growth restriction: risk factors, diagnostics, monitoring, delivery management, neonatal outcomes WP2.2 Feeding and Swallowing Disorders in Very Preterm Infants and their Impact on Speech and Language Outcomes at Pre-School Age  WP3 Cultural, Social and Psychological Aspects of Childbirth WP4 Neonatal Neurology, Early Development and Severe Encephalopathies of Children and Adolescents (Phase II MGCND00EP1) WP5 Physiotherapy Procedures in Obstetrics and Gynaecology WP6 Preeclampsia - Effects of Vitamin C Administration on Extravascular Lung Water in Patients with Severe Features of Preeclampsia: A Randomized, Placebo-Controlled Trial WP7 Impact of Anti-Müllerian Hormone (AMH) on Maturation and Quality of Human Oocytes: In Vitro Model

The research group combines the interests of obstetricians and gynaecologists, biochemists, a bioinformatics specialist, an electrophysiologist, a cardiologist, an embryologist, a sociologist, psychologists and physiotherapists. We actively promote comprehensive research activities related to embryology, prenatal and perinatal care, the neonatal period and early developmental period.

Using electrophysiological studies we wish to improve non-invasive prediction of preterm birth. Fetal growth restriction is one of the main reasons for fetal/neonatal mortality and the mortality of infants without developmental anomalies. The findings will help understand the occurrence and the course of fetal growth restriction and allow for the planning of pregnancy management with a growth restricted fetus. The development of targeted screening and better diagnostics will improve the possibilities of separating pathological and physiological fetal growth restriction. We will explore the development and implementation of modern concepts of health promotion in the perinatal period, thus contributing to the quality of everyday life of women (reproductive and family life). At the same time, we want to accelerate the provision of optimal conditions for creating and maintaining the health of family members. We will contribute to the understanding of the effects of medical cannabis, and we have designed a study in children and adolescents with resistant epilepsy that will confirm or refute the findings in this field using evidence-based medicine (double-blind, randomized, controlled). We will study vitamin C treatment in preecampsia patients after childbirth. If it proves to be effective, this safe and inexpensive treatment will be able to reduce the risk of pulmonary edema in preeclampsia and, consequently, improve the clinical treatment of patients with severe preeclampsia in the future. New basic knowledge about the quality and maturity of the oocyte can be important in the development of new, more individual protocols for hormonal ovarian stimulation, which is very important for young oncologic patients and patients in the program of IVF with a small number of oocytes.