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Projects / Programmes source: ARIS

Metabolic and hereditary factors of reproductive health, delivery

Periods
Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   
3.07.00  Medical sciences  Metabolic and hormonal disorders   
2.06.00  Engineering sciences and technologies  Systems and cybernetics   
6.06.00  Humanities  Culturology   

Code Science Field
B570  Biomedical sciences  Obstetrics, gynaecology, andrology, reproduction, sexuality 
B190  Biomedical sciences  Clinical chemistry 
Keywords
pregnancy, screening tests, chromosomopathies, teratology, mercury toxicity, thyroid diseases, iodine metabolism, menstrual irregularities, gene candidates for menopausis praecox, preterm delivery, biomedical signals analysis, characterisation of parameters, data mining of temporal lines, classification of time events, prediction of events, quality improvement for the parturient and individualized care, labour and delivery as physiological, cultural and psychological interaction, women's rights, labour and delivery culture, toxoplasmosis
Evaluation (rules)
source: COBISS
Researchers (34)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  26229  Tina Bukovec    Technical associate  2005 
2.  18541  Matjaž Centa    Technical associate  2005 - 2006 
3.  03896  PhD Matko-Vasili Cerar  Human reproduction  Researcher  2004 - 2008  129 
4.  15099  PhD Darko Černe  Pharmacy  Researcher  2004 - 2005  261 
5.  26066  Zdenka Dolinar    Technical associate  2005 - 2008 
6.  26063  Ida Domitrovič    Technical associate  2005 - 2006 
7.  14076  PhD Zalka Drglin  Sociology  Researcher  2004 - 2008  545 
8.  22621  PhD Polonca Ferk  Metabolic and hormonal disorders  Junior researcher  2004 - 2006  141 
9.  00814  PhD Ksenija Geršak  Human reproduction  Researcher  2004 - 2008  523 
10.  07652  PhD Vislava Globevnik Velikonja  Human reproduction  Researcher  2004 - 2008  316 
11.  17635  Klementa Habjan    Technical associate  2005 - 2008 
12.  03438  PhD Franc Jager  Computer science and informatics  Researcher  2004 - 2008  158 
13.  17160  PhD Aleš Jerin  Cardiovascular system  Researcher  2005 - 2008  196 
14.  28896  Nataša Jeršin    Technical associate  2007 - 2008 
15.  19426  MSc Gorazd Kavšek  Human reproduction  Junior researcher  2004 - 2008  98 
16.  17638  Meta Kovačič Lužnik    Technical associate  2005 - 2008 
17.  04216  PhD Živa Novak-Antolič  Human reproduction  Head  2004 - 2008  418 
18.  26064  Ljuba Orel    Technical associate  2005 - 2008 
19.  10691  PhD Joško Osredkar  Human reproduction  Researcher  2004 - 2008  1,305 
20.  18636  Janez Pavlič    Technical associate  2005 - 2008 
21.  22159  Martina Pečlin    Technical associate  2005 - 2008 
22.  14534  Mojca Pirc  Human reproduction  Technical associate  2005 - 2008  23 
23.  00789  PhD Tanja Premru-Sršen  Human reproduction  Researcher  2004 - 2008  359 
24.  03893  PhD Marija Prezelj  Human reproduction  Researcher  2006 - 2008  218 
25.  17649  Mirjana Puršič    Technical associate  2005 - 2008 
26.  17431  Stanislava Sever    Technical associate  2007 - 2008 
27.  11331  PhD Milan Skitek  Oncology  Researcher  2004 - 2008  326 
28.  18199  PhD Aleš Smrdel  Computer science and informatics  Researcher  2005 - 2007  86 
29.  26065  Darja Strnad-Tetičkovič    Technical associate  2005 - 2008 
30.  15150  PhD Irena Štucin-Gantar  Human reproduction  Researcher  2005 - 2008  103 
31.  17653  Danica Štuhec    Technical associate  2005 - 2008 
32.  15638  PhD Nataša Tul-Mandić  Human reproduction  Researcher  2005 - 2008  362 
33.  26062  Sabina Zupan    Technical associate  2005 - 2006 
34.  20077  Sabina Žitko    Technical associate  2005 - 2008 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,627 
2.  0581  University of Ljubljana, Faculty of Arts  Ljubljana  1627058  97,082 
3.  1539  University of Ljubljana, Faculty of Computer and Information Science  Ljubljana  1627023  16,011 
Abstract
1. Screening tests for chromosomopathies and pregnancy complications. Free beta HCG nd PAPP-A values between 11. and 14. week of gestation in pregnant women with trisomy 21, trisomy 18 or sex chromosomes abberations are different from the values in pregnant women with normal fetuses. The values of these markers can also be different in women where fetal karyotype is normal but complications in pregnancy occur. Screening tests for Slovenia will be validated. Analysis of false positive results, predictive values and appropriateness according to the population characteristics will be performed. 2. Influence of chemical and biochemical factors on reproductive health. Those toxic, subtoxic and biological effects of mercury, connected to lipid peroxidation and oxidative DNA damage will be studied as well as some biological markers. Cumulation of mercury in epiphysis, anterior hypophysis, thyroid gland and testes can potentially influence function of the glands. We will evaluate the effects of mercury retrospectively; in the city of Idrija after 500 years of mercury mine functioning the pollution and exposition are high. 3. The incidence and forms of thyroid dysfunction in reproductive period. We will try to evaluate if the iodine intake in pregnancy in Slovenia is adequate, as this has influences on the fetus and the incidence of thyroid diseases later in life. We want to ascertain the incidence of thyroid diseases in pregnancy and puerperium and etiology of these diseases for our population. 4. Hereditary factors of menstrual irregularities. In patients with menstrual irregularities we will continue with analysing some of the genetical factors (DNA ploidy of granulosa-thecca cells, mutaitions in the GALT gene, variations in the CYP11a gene). 5. Preterm delivery is the most frequent complication in pregnancy, adding most to perinatal morbidity and mortality. With additional analyses of signals of electrohysterograms we will try to improve predictive value for preterm delivery and institute a system with simple and repeatable recording of signals. Psychological stress and labor and delivery as the central life event will be studied. 6. Primary infection with Toxoplasma gondii in pregnancy. Study of congenital toxoplasmosis detection with DNA analysis of amniotic fluid with PCR analysis will be performed.
Significance for science
We are estimating usefulness of different linear and non-linear signal processing techniques to analyze electromyogram of uterus for differentiating between labours at the estimated date and pre-term labours. The most useful appeared to be the median frequency and the sample entropy. We developed faster algorithm to calculate the sample entropy. We are analyzing records of electrical activity of uterus early during the pregnancy, as opposed to majority of other researches, who analyze records just prior to the delivery. In the scope of the project we also developed a web interface for dislocated entering of data about the pregnancies, which allows adaptability and flexibility of the interface during creating the pages to enter the data, and supports its portability. The interface developed is user friendly and follows all modern widely accepted principles and guidelines for designing user interfaces: full user control, reducing user memory load and consistency. Research focus on developing different concepts (as medicalizaton, institutionalization, tehnologization of human reproductive life) has a special meaning for theoretical interdisciplinary work; as developing deeper understanding and new perspectives on the complex processes of women becoming mothers. New methods for researching childbirth culture has been developed and implemented. Data bases on contemporary chilbirth culture in Slovenia give an opportunity for future reseachers interested in medicine, midwifery, sociology, anthropoloy and history and for international comparision of the birth systems.
Significance for the country
We are working to improve predicting of pre-term delivery which is associated with considerable costs. We are maintaining position of our research group among the leading groups in the world in this field. We developed new non-invasive non-linear signal processing techniques to help estimate the risk for pre-term labour.
Most important scientific results Final report, complete report on dLib.si
Most important socioeconomically and culturally relevant results Final report, complete report on dLib.si
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